Abstract: The invention relates to novel regulators of plasminogen activation and their use for regulating cell migration, plasminolysis, angiogenesis, fibrinolysis, for treating cancer and thrombo-embolic diseases such as heart stroke. Furthermore, the present invention relates to novel pharmaceutical compositions form regulating cell migration, plasminolysis, angiogenesis and for treating cancer. In particular, the present invention relates to a method of regulating the activation of plasminogen comprising contacting a solution of pro-urokinase (uPA) or tissue plasminogen activator (tPA) and plasminogen with melanotransferrin (p97) for a time sufficient to effect regulation thereof.
Type:
Application
Filed:
March 28, 2011
Publication date:
October 6, 2011
Applicant:
TRANSFERT PLUS
Inventors:
Richard Béliveau, Michel Demeule, Yanick Bertrand, Jonathan Michaud-Levesque, Yannève Rolland, Julie Jodoin
Abstract: The invention relates to novel regulators of plasminogen activation and their use for regulating cell migration, plasminolysis, angiogenesis, fibrinolysis, for treating cancer and thrombo-embolic diseases such as heart stroke. Furthermore, the present invention relates to novel pharmaceutical compositions form regulating cell migration, plasminolysis, angiogenesis and for treating cancer. In particular, the present invention relates to a method of regulating the activation of plasminogen comprising contacting a solution of pro-urokinase (uPA) or tissue plasminogen activator (tPA) and plasminogen with melanotransferrin (p97) for a time sufficient to effect regulation thereof.
Type:
Grant
Filed:
May 7, 2004
Date of Patent:
April 5, 2011
Assignee:
Transfert Plus
Inventors:
Richard Béliveau, Michel Demeule, Yanick Bertrand, Jonathan Michaud-Levesque, Yannève Rolland, Julie Jodoin
Abstract: The invention relates to novel regulators of plasminogen activation and their use for regulating cell migration, plasminolysis, angiogenesis, fibrinolysis, for treating cancer and thrombo-embolic diseases such as heart stroke. Furthermore, the present invention relates to novel pharmaceutical compositions form regulating cell migration, plasminolysis, angiogenesis and for treating cancer. In particular, the present invention relates to a method of regulating the activation of plasminogen comprising contacting a solution of pro-urokinase (uPA) or tissue plasminogen activator (tPA) and plasminogen with melanotransferrin (p97) for a time sufficient to effect regulation thereof.
Type:
Application
Filed:
May 7, 2004
Publication date:
March 8, 2007
Applicant:
TRANSFERT PLUS
Inventors:
Richard Beliveau, Michel Demeule, Yanick Bertrand, Jonathan Michaud-Levesque, Yanneve Rolland, Julie Jodoin