Abstract: The present application relates to methods and uses of conjugates comprising antitumor agents (e.g., chemotherapeutic agents) conjugated to peptide compounds targeting Sortilin-expressing cancer stem cells (CSCs), in embodiments for the treatment of poor prognosis cancers refractory to standard antitumor therapies associated the presence of Sortilin-expressing CSCs, and for preventing or treating cancer relapse or recurrence.

Abstract: Within many applications impulse radio based ultra-wideband (IR-UWB) transmission offers significant benefits for very short range high data rate communications when compared with existing standards and protocols. In many of these applications the main design goals are very low power consumption and very low complexity design for easy integration and cost reduction. Digitally programmable IR-UWB transmitters using an on-off keying modulation scheme on a 0.13 microns CMOS process operating on 1.2V supply and yielding power consumption as low as 0.9 mW at a 10 Mbps data rate with dynamic power control are enabled. The IR-UWB transmitters support new frequency hopping techniques providing more efficient spectrum usage and dynamic allocation of the spectrum when transmitting in highly congested frequency bands. Biphasic scrambling is also introduced for spectral line reduction.

Abstract: Photonic integration has primarily sought to exploit optical parallelism through wavelength division multiplexing whilst in many instances “brute-force” time division multiplexing offers benefits through reduced complexity and cost. However, photoreceivers are primarily the same now for operation at 10 Gb/s, 20 Gb/s, 40 Gb/s and above as 20 or 25 years ago and exploit the same optical detection—amplification—logic processing design. However, high speed low cost electronics ca be leveraged in conjunction with optical time sampling and logic to provide a new design paradigm. An incoming XGbs?1 optical data stream is sampled and processed by N photodetectors each operating at (X/N)Gbs?1 rather than the current direct XGbs?1 front-end of the prior art. Flexibility for the designer in establishing N within optical layer constraints, electronics capabilities etc.

Abstract: Photonic integration has primarily sought to exploit optical parallelism through wavelength division multiplexing whilst in many instances “brute-force” time division multiplexing offers benefits through reduced complexity and cost. However, photoreceivers are primarily the same now for operation at 10 Gb/s, 20 Gb/s, 40 Gb/s and above as 20 or 25 years ago and exploit the same optical detection—amplification—logic processing design. However, high speed low cost electronics ca be leveraged in conjunction with optical time sampling and logic to provide a new design paradigm. An incoming XGbs?1 optical data stream is sampled and processed by N photodetectors each operating at (X/N)Gbs?1 rather than the current direct XGbs?1 front-end of the prior art. Flexibility for the designer in establishing N within optical layer constraints, electronics capabilities etc.