Patents Assigned to Transgenic Inc.
  • EXON-HUMANIZED MOUSE
    Publication number: 20220340926
    Abstract: Provided are a donor vector having an exon-humanized gene in which only exon nucleotide sequences of a mouse gene are replaced with human exon nucleotide sequences, an ES cell in which a mouse endogenous gene is replaced with the donor vector, and a mouse crated by using the ES cell.
    Type: Application
    Filed: May 27, 2019
    Publication date: October 27, 2022
    Applicant: TRANSGENIC INC.
    Inventors: Kenichi YAMAMURA, Zhenghua LI
  • Inflammation reporter system
    Patent number: 10765094
    Abstract: The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: September 8, 2020
    Assignees: TRANSGENIC INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
    Inventors: Kenichi Yamamura, Takao Iwawaki, Daisuke Oikawa, Tomoo Ishikawa
  • ORGAN HUMANIZED MOUSE
    Publication number: 20180360006
    Abstract: The present invention provides embryonic stem cells obtained from an embryo of a mouse engineered to replace all or some of domains in the mouse MHC class I molecule H2-D with domains from the human MHC class I molecule HLA-A by culture in the presence of a GSK3 inhibitor and an MEK inhibitor, as well as a mouse which is created with the use of these embryonic stem cells.
    Type: Application
    Filed: June 18, 2015
    Publication date: December 20, 2018
    Applicant: TRANSGENIC INC.
    Inventors: Kenichi YAMAMURA, Zhenghua LI
  • INFLAMMATION REPORTER SYSTEM
    Publication number: 20170215394
    Abstract: The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory reaction induced upon inflammatory stimulation in the transformant or in the transgenic non-human animal.
    Type: Application
    Filed: July 31, 2014
    Publication date: August 3, 2017
    Applicants: TRANSGENIC INC., NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY
    Inventors: Kenichi YAMAMURA, Takao IWAWAKI, Daisuke OIKAWA, Tomoo ISHIKAWA
  • High specificity monoclonal antibody against a protein or a polypeptide having oxidative modification
    Patent number: 8883972
    Abstract: The present invention provides an antibody, which reacts with a FGA or FGA partial peptide in which a part of prolines in the molecule thereof are hydroxylated, and which does not react with an unmodified FGA or FGA partial peptide.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: November 11, 2014
    Assignees: Transgenic Inc., President, National Cancer Center
    Inventors: Hiroshi Nose, Tomoyo Hashiguchi, Masaya Ono, Tesshi Yamada, Setsuo Hirohashi
  • Trap vectors and gene trapping method by using the same
    Patent number: 8722408
    Abstract: A trap vector containing a loxP sequence composed of inverted repeat sequence 1, a spacer sequence and inverted repeat sequence 2 in this order, the loxP sequence being a mutant loxP wherein a part of the inverted repeat sequence 1 or 2 is mutated.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: May 13, 2014
    Assignee: Transgenic Inc.
    Inventors: Ken-ichi Yamamura, Kimi Araki
  • Trap vectors and gene trapping using the same
    Publication number: 20090202988
    Abstract: A trap vector containing a loxP sequence composed of inverted repeat sequence 1, a spacer sequence and inverted repeat sequence 2 in this order, the loxP sequence being a mutant loxP wherein a part of the inverted repeat sequence 1 or 2 is mutated.
    Type: Application
    Filed: October 12, 2007
    Publication date: August 13, 2009
    Applicant: TRANSGENIC INC.
    Inventors: Ken-ichi Yamamura, Kimi Araki
  • Trap vectors and gene trapping by using the same
    Patent number: 7312075
    Abstract: A trap vector containing a loxP sequence composed of inverted repeat sequence 1, a spacer sequence and inverted repeat sequence 2 in this order, the loxP sequence being a mutant loxP wherein a part of the inverted repeat sequence 1 or 2 is mutated.
    Type: Grant
    Filed: May 2, 2000
    Date of Patent: December 25, 2007
    Assignee: Transgenic Inc.
    Inventors: Ken-ichi Yamamura, Kimi Araki
  • Transgenically produced Antithrombin III
    Patent number: 6441145
    Abstract: This invention relates to transgenically produced human Antithrombin III (tgATIII). The human ATIII produced by the transgenic process of the present invention has a monosaccharide composition which comprises N-acetylgalactosamine (GaINAc) along with fucose, N-acetylglucosamine, galactose, mannose, and N-acetylneuraminic acid/N-glycolyneuraminic acid. The monosaccharide composition differs with that of plasma derived ATIII (phATIII). It has been found that tgATIII has an increased clearance rate when compared to phATIII.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: August 27, 2002
    Assignee: Genzyme Transgenics, Inc.
    Inventors: Paul DiTullio, Harry Meade, Edward S. Cole