Patents Assigned to Transimmune AG
  • SELECTIVE TOLERIZATION - METHODS OF SELECTIVELY GENERATING TOLEROGENIC DENDRITIC CELLS
    Publication number: 20250375477
    Abstract: The present invention relates to methods of selectively generating tolerogenic dendritic cells. The present invention further relates to patient-specific tolerogenic dendritic cells obtained by the described methods which reduce immunogenicity of a transplant when administered prior to transplantation. The present invention also relates to patient-specific tolerogenic dendritic cells for use in reducing or preventing inflammatory conditions such as graft-versus-host disease. Specifically, the methods can be used to reduce graft versus host disease. The tolerogenic dendritic cells of the present invention can also be used for the treatment of autoimmune diseases.
    Type: Application
    Filed: July 29, 2022
    Publication date: December 11, 2025
    Applicants: TRANSIMMUNE AG, YALE UNIVERSITY
    Inventors: Richard EDELSON, Karsten HENCO, Olga SOBOLEV, Douglas HANLON, Aaron VASSALL, Kazuki TATSUNO, Patrick HAN
  • Method for obtaining globally activated monocytes
    Patent number: 12364755
    Abstract: The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.
    Type: Grant
    Filed: November 18, 2021
    Date of Patent: July 22, 2025
    Assignees: Transimmune AG, Yale University
    Inventors: Günter Bauer, Justin Duckworth, Robert Tigelaar, Richard Edelson, Michael Girardi, Karsten Henco, Adrian Hayday
  • METHODS FOR SELECTIVELY REDUCING IMMUNOGENICITY IN A TRANSPLANT
    Publication number: 20250084370
    Abstract: The present invention relates to methods for reducing or eliminating reactive T cells from a transplant or a part thereof prior to transplantation. The present invention also relates to methods for reducing immunogenicity in a transplant or a part thereof prior to transplantation. The present invention further relates to transplants obtained by the described methods and apoptotic agent treated transplants for use in reducing or preventing inflammatory conditions such as graft-versus-host disease. Specifically, the methods can be used to reduce graft versus host disease following transplantation.
    Type: Application
    Filed: July 29, 2022
    Publication date: March 13, 2025
    Applicants: TRANSIMMUNE AG, YALE UNIVERSITY
    Inventors: Richard EDELSON, Olga SOBOLEV, Douglas HANLON, Aaron VASSAL, Kazuki TATSUNO, Patrick HAN
  • Method for obtaining globally activated monocytes
    Patent number: 11179417
    Abstract: The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: November 23, 2021
    Assignees: Transimmune AG, Yale University
    Inventors: Gunter Bauer, Justin Duckworth, Robert Tigelaar, Richard Edelson, Michael Girardi, Karsten Henco, Adrian Hayday