Patents Assigned to TranSINE Therapeutics Limited
  • MODIFIED FUNCTIONAL NUCLEIC ACID MOLECULES
    Publication number: 20230383293
    Abstract: The invention relates to functional nucleic acid molecules comprising a target determinant sequence and a regulatory sequence wherein the functional nucleic acid molecule comprises one or more chemical modifications, particularly for use in methods of increasing target protein synthesis efficiency.
    Type: Application
    Filed: September 24, 2021
    Publication date: November 30, 2023
    Applicants: FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, SCUOLA INTERNAZIONALE SUPERIORE DI STUDI AVANZATI, TRANSINE THERAPEUTICS LIMITED
    Inventors: Piero CARNINCI, Hazuki TAKAHASHI, Naoko TOKI, Stefano GUSTINCICH, Bianca PIERATTINI, Paola VALENTINI
  • STRUCTURAL DOMAINS OF ANTISENSE RNA MOLECULES UP-REGULATING TRANSLATION
    Publication number: 20210139898
    Abstract: There are disclosed functional nucleic acid molecules comprising a target binding sequence comprising a sequence reverse complementary to a target mRNA sequence for which protein translation is to be enhanced; and a regulatory sequence having two-dimensional structures comprising specific stem-loop and internal loop domains and displaying translation enhancing efficiency.
    Type: Application
    Filed: February 5, 2019
    Publication date: May 13, 2021
    Applicants: Scuola Internazionale Superiore Di Studi Avanzati ? SISSA, TranSINE Therapeutics Limited
    Inventors: Stefano GUSTINCICH, Silvia ZUCCHELLI, Peter PODBEVSEK, Janez PLAVEC, Piero CARNINCI, Hazuki TAKAHASHI, Toshio YAMAZAKI, Takako OHYAMA, Harshita SHARMA