Patents Assigned to TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE
  • APTAMER AGAINST M.TB MPT51 AND USES THEREOF
    Publication number: 20200283774
    Abstract: The invention provides single stranded DNA aptamers specific to M.tb MPT51 and uses thereof in rapid, robust, highly specific, and cost effective diagnosis of tuberculosis. The invention also provides methods and devices based on the aptamers of the invention for the diagnosis of tuberculosis. Advantageously, aptamers of the present invention can selectively detect as low as 2 ng of M.tb MPT51 and this activity remains unaltered in presence of anti-MPT51 antibodies. The developed device can give sample-to-answer within 30 minutes.
    Type: Application
    Filed: September 7, 2018
    Publication date: September 10, 2020
    Applicants: TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE, ALL INDIA INSTITUTE OF MEDICAL SCIENCES, APTABHARAT INNOVATION PRIVATE LIMITED
    Inventors: Tarun KUMAR SHARMA, Jaya SIVASWAMI TYAGI, Ritu DAS, Abhijeet DHIMAN
  • A CYCLIC PEPTIDE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR INHIBITING PROLIFERATION OF HEV
    Publication number: 20200115417
    Abstract: An objective of the present invention is to provide a means for inhibiting progression of HEV infection in a host by use of a cyclic peptide including the amino acid sequence of SEQ ID No: 1 which inhibits interaction between HEV ORF3 domain and host TSG101 which is crucial for HEV proliferation in a host or an expression vector coding for the cyclic peptide or a pharmaceutical composition comprising the cyclic peptide with pharmaceutically acceptable carriers.
    Type: Application
    Filed: July 23, 2018
    Publication date: April 16, 2020
    Applicant: TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE
    Inventors: Surjit MILAN, Saumya ANANG