Abstract: A method and system provides the ability to detect density of a women's breast by obtaining the concentration of at least one selected biochemical in the breast using a spectrometer, and comparing the concentration obtained with reference measurements which correlate breast density with concentration of the at least one selected biochemical.
Type:
Application
Filed:
July 22, 2021
Publication date:
January 27, 2022
Applicant:
Translational Research Institute Pty Ltd as trustee for Translational Research Institute Trust
Inventors:
Carolyn Mountford, Gorane Santamaria, Peter Malycha, Natali Naude
Abstract: A method and system for detecting the presence of BRCS carriers in breast tissue, comprises obtaining spectral data from breast tissue using a magnetic resonance spectroscopy device and producing spectral data by said device which provides chemical markers to enable detection of whether the breast tissue contains BRCA carriers.
Type:
Grant
Filed:
March 17, 2014
Date of Patent:
August 24, 2021
Assignee:
TRANSLATIONAL RESEARCH INSTITUTE PTY LTD AS TRUSTEE OF TRANSLATIONAL RESEARCH INSTITUTE TRUST
Inventors:
Saadallah Ramadan, Gorane Santamaria, Peter Malycha, Carolyn Mountford, David Clarke
Abstract: A method and system for monitoring therapeutic interventions for treating a patient with PTSD comprises using a scanner to obtain pre-treatment neural spectroscopic data of at least one neuromarker chemical in the brain of the patient before treatment, treating the patient with at least one treatment protocol, after treatment, obtaining post-treatment neural spectroscopic data of the at least one neuromarker chemical in the brain of the patient, and comparing the results of the pre-treatment and post-treatment data to enable a determination of the effectiveness of the treatment.
Type:
Application
Filed:
February 14, 2020
Publication date:
August 20, 2020
Applicant:
Translational Research Institute Pty Ltd as trustee for Translational Research Institute Trust
Inventors:
Carolyn Mountford, David Crompton, Nathan Tosh, Rosanna Tremewan
Abstract: A method and system obtains spectral data from the brain of a person undergoing treatment for pain to determine whether the concentration of new chemicals including fucosylated glycans indicates fucosylated glycan concentration levels of a person experiencing pain or returning to normal levels of a healthy person who is not experiencing pain, to assess the person's response to treatment and progress.
Type:
Application
Filed:
March 26, 2020
Publication date:
July 23, 2020
Applicant:
Translational Research Institute Pty Ltd as trustee for Translational Research Institute Trust
Abstract: An integrated MRI and MRS system includes a plurality of different classifiers for detecting the likelihood of the new data to be one of the different diseases/conditions in different body organs, and even the progression of the disease, disease state and condition within that organ.
Type:
Application
Filed:
January 7, 2020
Publication date:
July 9, 2020
Applicant:
Translational Research Institute Pty Ltd as trustee for Translational Research Institute Trust
Abstract: One dimensional (1D) and two dimensional (2D) MR spectroscopy of the brain provides an objective test for pain and level of pain. There are two ways of evaluating the data. The first is conventional analysis of the 2D MRS. The second us the use of data mining methods such as testing for correlation between wavelet-based features and self-reported pain intensity, the MBDA method. Both found multiple spectral regions that were highly correlated with self-reported pain. Two of these spectral regions are consistent with changes to the recently assigned substrate ?-L Fucose and the Fuc-?(1-2) glycans in the human brain. There are common features recorded compared with prior reports using the MBDA method to evaluate pain associated with spinal cord injury and low back pain.
Type:
Application
Filed:
December 9, 2019
Publication date:
June 11, 2020
Applicant:
Translational Research Institute Pty Ltd as trustee for Translational Research Institute Trust
Abstract: A method and system for enabling a practitioner to detect acute stress disorder and PTSD using fMRI comprises looking at functional connectivity dynamics within the visual pathways, limbic, thalamic, paralimbic and prefrontal brain networks observed when individuals are viewing visual images of different facial expressions.
Type:
Application
Filed:
October 24, 2019
Publication date:
April 30, 2020
Applicant:
Translational Research Institute Pty Ltd as trustee for Translational Research Institute Trust
Abstract: The present invention relates to a method and system for using neurochemical markers to enable whether a subject is experiencing acute stress, trauma, or PTSD and providing the capacity to monitor response to therapy on an individual basis. The markers can be an increase of NAA, glutamine or Fuc IV and lactate and a decrease of Fuc IV during the transition from acute stress to PTSD.
Type:
Application
Filed:
July 30, 2019
Publication date:
January 30, 2020
Applicant:
Translational Research Institute Pty Ltd as trustee for Translational Research Institute Trust
Abstract: The present invention relates to an MRS 1D or 2D method and system for obtaining spectral data of the brain of a subject and using neurochemical markers to enable whether a subject is experiencing acute pain, and providing the capacity to monitor response to therapy on an individual basis. The markers can be an increase of Fuc II, III, IV, VII and lactate.
Type:
Application
Filed:
July 3, 2019
Publication date:
January 9, 2020
Applicant:
Translational Research Institute Pty Ltd as trustee for Translational Research Institute Trust