Patents Assigned to Translocus Limited
  • MOUSE LAMBDA LIGHT CHAIN LOCUS
    Publication number: 20110093961
    Abstract: The present invention provides in a first aspect a mouse in which the ? (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse ? light chain locus was functional silenced by deletion of gene segments coding for the ? light chain locus. In a further aspect, a mouse containing functionally silenced ? and ? (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
    Type: Application
    Filed: June 1, 2009
    Publication date: April 21, 2011
    Applicant: TRANSLOCUS LIMITED
    Inventors: MARIANNE BRUGGEMANN, XIANGANG ZOU
  • Mouse ? light chain locus
    Patent number: 7541513
    Abstract: The present invention provides in a first aspect a mouse in which the ?(lambda) light chain locus has been functionally silenced. In one embodiment, the mouse ? light chain locus was functional silenced by deletion of gene segments coding for the ? light chain locus. In a further aspect, a mouse containing functionally silenced ? and ? (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: June 2, 2009
    Assignee: Translocus Limited
    Inventors: Marianne Bruggeman, Xiangang Zou