Patents Assigned to TransMedics, Inc.
  • Publication number: 20240264144
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.
    Type: Application
    Filed: March 14, 2024
    Publication date: August 8, 2024
    Applicant: TransMedics, Inc.
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Robert HAVENER, Stanley KYI, Ihab Abdel FATTAH, Hesham SALEH, Jon C. TRACHTENBERG
  • Publication number: 20230413805
    Abstract: The disclosure, in various embodiments, provides systems, methods, and solutions for perfusing an organ. The present application describes illustrative methods for perfusing an ex-vivo organ in a functioning state under physiological or near physiological conditions, including receiving an ex-vivo organ in an organ care system, the ex-vivo organ coupled to a perfusion circuit, infusing a solution into the system, combining the solution with a perfusion fluid to create a mixed solution, pumping the mixed solution to the ex-vivo organ, and receiving the mixed solution from the ex-vivo organ.
    Type: Application
    Filed: September 1, 2023
    Publication date: December 28, 2023
    Applicant: TransMedics, Inc.
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Paul LEZBERG
  • Publication number: 20190110466
    Abstract: The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.
    Type: Application
    Filed: December 21, 2018
    Publication date: April 18, 2019
    Applicant: TransMedics, Inc.
    Inventors: Greg RITCHIE, Vincent LAMBERT, II, Richard BRINGHAM, John SULLIVAN, Waleed H. HASSANEIN
  • Publication number: 20190021308
    Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.
    Type: Application
    Filed: September 13, 2018
    Publication date: January 24, 2019
    Applicant: TransMedics, Inc.
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Jeff BARNES, Greg RITCHIE, Richard BRINGHAM, Mark ANDERSON, John SULLIVAN
  • Publication number: 20190014774
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.
    Type: Application
    Filed: August 2, 2018
    Publication date: January 17, 2019
    Applicant: TransMedics, Inc.
    Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Paul LEZBERG
  • Publication number: 20160374332
    Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a heating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
    Type: Application
    Filed: July 11, 2016
    Publication date: December 29, 2016
    Applicant: TransMedics, Inc
    Inventors: Waleed H. HASSANEIN, Ahmed ELBETANONY, Richard BRINGHAM, Robert HAVENER, Vincent LAMBERT, II, Burt OCHS
  • Patent number: 9078428
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: July 14, 2015
    Assignee: TransMedics, Inc.
    Inventors: Waleed Hassanein, Paul Lezberg, Tamer Khayal
  • Patent number: 8822203
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: September 2, 2014
    Assignee: TransMedics, Inc.
    Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon C. Trachtenberg
  • Patent number: 8585380
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: November 19, 2013
    Assignee: Transmedics, Inc.
    Inventors: Waleed Hassanein, Richard Bringham, Robert Fishman, Larry Goff, Stanley Kyi, Jonathan Rourke, Dmitri Menn, David Carpenter, Robert Havner
  • Patent number: 8535934
    Abstract: The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: September 17, 2013
    Assignee: TransMedics, Inc.
    Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon Trachtenberg
  • Patent number: 8465970
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: June 18, 2013
    Assignee: TransMedics, Inc.
    Inventors: Waleed Hassanein, Richard Bringham, Giovanni Cecere, Ahmed Elbetanony, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Scott Newell, Burt Ochs, Dennis Sousa, Ronald Taylor, Jonathan Rourke, Hossam Algamil, David Carpenter, Robert Havner, Dmitri Menn
  • Patent number: 8420380
    Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
    Type: Grant
    Filed: April 8, 2008
    Date of Patent: April 16, 2013
    Assignee: TransMedics, Inc.
    Inventors: Robert Fishman, Robert Havener, Ihab Abdel Fattah, Anas Abdelazim, Scott Newell, Tom Bishop, Tamer Khayal, Stanley Kyi, Ron Taylor, Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed Hassanein
  • Patent number: 8304181
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
    Type: Grant
    Filed: April 25, 2007
    Date of Patent: November 6, 2012
    Assignee: Transmedics, Inc.
    Inventors: Waleed Hassanein, Tamer Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen
  • Publication number: 20110136096
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.
    Type: Application
    Filed: September 28, 2010
    Publication date: June 9, 2011
    Applicant: TransMedics, Inc.
    Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon C. Trachtenberg
  • Patent number: 7651835
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: January 26, 2010
    Assignee: TransMedics, Inc.
    Inventors: Waleed Hassanein, Richard Bringham, Giovanni Cecere, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Burt Ochs, Scott Newell, Ronald Taylor, Hossam Algamil, Thomas Bishop, Robert Havner, Dmitri Menn
  • Patent number: 7572622
    Abstract: A heart preservation chamber is disclosed which comprises a housing, an inclined trough support surface, and inlet and outlet fluid connections for the major heart blood vessels.
    Type: Grant
    Filed: August 14, 2003
    Date of Patent: August 11, 2009
    Assignee: TransMedic, Inc.
    Inventors: Waleed H. Hassanein, Richard L. Bringham, Ronald L. Taylor, Jr.
  • Publication number: 20080234768
    Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.
    Type: Application
    Filed: July 6, 2007
    Publication date: September 25, 2008
    Applicant: TransMedics, Inc
    Inventors: Waleed Hassanein, Ahmed Elbetanony, Richard Bringham, Robert Havener, Vincent Lambert, Burt Ochs
  • Publication number: 20080017194
    Abstract: The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.
    Type: Application
    Filed: April 19, 2007
    Publication date: January 24, 2008
    Applicant: TransMedics, Inc
    Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Fattah, Hesham Saleh, Jon Trachtenberg
  • Publication number: 20070190636
    Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.
    Type: Application
    Filed: October 7, 2005
    Publication date: August 16, 2007
    Applicant: TransMedics, Inc.
    Inventors: Waleed Hassanein, Thomas Bishop, Richard Bringham, Giovanni Cecere, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Burt Ochs, Scott Newell, Ronald Taylor, Hassam Algamil, Robert Havner, Dmitri Menn
  • Publication number: 20060292544
    Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.
    Type: Application
    Filed: October 7, 2005
    Publication date: December 28, 2006
    Applicant: TransMedics, Inc.
    Inventors: Waleed Hassanein, Paul Lezberg, Tamer Khayal