Patents Assigned to TransMedics, Inc.
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Publication number: 20240264144Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.Type: ApplicationFiled: March 14, 2024Publication date: August 8, 2024Applicant: TransMedics, Inc.Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Robert HAVENER, Stanley KYI, Ihab Abdel FATTAH, Hesham SALEH, Jon C. TRACHTENBERG
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Publication number: 20230413805Abstract: The disclosure, in various embodiments, provides systems, methods, and solutions for perfusing an organ. The present application describes illustrative methods for perfusing an ex-vivo organ in a functioning state under physiological or near physiological conditions, including receiving an ex-vivo organ in an organ care system, the ex-vivo organ coupled to a perfusion circuit, infusing a solution into the system, combining the solution with a perfusion fluid to create a mixed solution, pumping the mixed solution to the ex-vivo organ, and receiving the mixed solution from the ex-vivo organ.Type: ApplicationFiled: September 1, 2023Publication date: December 28, 2023Applicant: TransMedics, Inc.Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Paul LEZBERG
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Publication number: 20190110466Abstract: The invention provides, in various embodiments, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to aortic cannulas for use in perfusion systems to return perfusate to the heart or delivering perfusate from the heart while the organ is sustained ex vivo at physiologic or near-physiologic conditions.Type: ApplicationFiled: December 21, 2018Publication date: April 18, 2019Applicant: TransMedics, Inc.Inventors: Greg RITCHIE, Vincent LAMBERT, II, Richard BRINGHAM, John SULLIVAN, Waleed H. HASSANEIN
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Publication number: 20190021308Abstract: The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.Type: ApplicationFiled: September 13, 2018Publication date: January 24, 2019Applicant: TransMedics, Inc.Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Ahmed ELBETANONY, Jeff BARNES, Greg RITCHIE, Richard BRINGHAM, Mark ANDERSON, John SULLIVAN
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Publication number: 20190014774Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.Type: ApplicationFiled: August 2, 2018Publication date: January 17, 2019Applicant: TransMedics, Inc.Inventors: Waleed H. HASSANEIN, Tamer I. KHAYAL, Paul LEZBERG
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Publication number: 20160374332Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a heating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.Type: ApplicationFiled: July 11, 2016Publication date: December 29, 2016Applicant: TransMedics, IncInventors: Waleed H. HASSANEIN, Ahmed ELBETANONY, Richard BRINGHAM, Robert HAVENER, Vincent LAMBERT, II, Burt OCHS
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Patent number: 9078428Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.Type: GrantFiled: October 7, 2005Date of Patent: July 14, 2015Assignee: TransMedics, Inc.Inventors: Waleed Hassanein, Paul Lezberg, Tamer Khayal
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Patent number: 8822203Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.Type: GrantFiled: September 28, 2010Date of Patent: September 2, 2014Assignee: TransMedics, Inc.Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon C. Trachtenberg
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Patent number: 8585380Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.Type: GrantFiled: October 7, 2005Date of Patent: November 19, 2013Assignee: Transmedics, Inc.Inventors: Waleed Hassanein, Richard Bringham, Robert Fishman, Larry Goff, Stanley Kyi, Jonathan Rourke, Dmitri Menn, David Carpenter, Robert Havner
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Patent number: 8535934Abstract: The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.Type: GrantFiled: April 19, 2007Date of Patent: September 17, 2013Assignee: TransMedics, Inc.Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon Trachtenberg
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Patent number: 8465970Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.Type: GrantFiled: October 7, 2005Date of Patent: June 18, 2013Assignee: TransMedics, Inc.Inventors: Waleed Hassanein, Richard Bringham, Giovanni Cecere, Ahmed Elbetanony, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Scott Newell, Burt Ochs, Dennis Sousa, Ronald Taylor, Jonathan Rourke, Hossam Algamil, David Carpenter, Robert Havner, Dmitri Menn
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Patent number: 8420380Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.Type: GrantFiled: April 8, 2008Date of Patent: April 16, 2013Assignee: TransMedics, Inc.Inventors: Robert Fishman, Robert Havener, Ihab Abdel Fattah, Anas Abdelazim, Scott Newell, Tom Bishop, Tamer Khayal, Stanley Kyi, Ron Taylor, Doug Harriott, Matthew De Remer, Paul Murray, John Sullivan, Mark Anderson, Richard Bringham, Michael Van Driel, Waleed Hassanein
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Patent number: 8304181Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate the: 1) The overall perfusion status of an isolated heart and 2) The metabolic status of an isolated heart and 3) the overall vascular patency of an isolated donor heart. This aspect of the present invention uses the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.Type: GrantFiled: April 25, 2007Date of Patent: November 6, 2012Assignee: Transmedics, Inc.Inventors: Waleed Hassanein, Tamer Khayal, Ahmed Elbetanony, Paul Lezberg, Giovanni Cecere, Dennis Sousa, Elizabeth Hansen
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Publication number: 20110136096Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ ex vivo.Type: ApplicationFiled: September 28, 2010Publication date: June 9, 2011Applicant: TransMedics, Inc.Inventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Abdel Fattah, Hesham Saleh, Jon C. Trachtenberg
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Patent number: 7651835Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.Type: GrantFiled: October 7, 2005Date of Patent: January 26, 2010Assignee: TransMedics, Inc.Inventors: Waleed Hassanein, Richard Bringham, Giovanni Cecere, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Burt Ochs, Scott Newell, Ronald Taylor, Hossam Algamil, Thomas Bishop, Robert Havner, Dmitri Menn
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Patent number: 7572622Abstract: A heart preservation chamber is disclosed which comprises a housing, an inclined trough support surface, and inlet and outlet fluid connections for the major heart blood vessels.Type: GrantFiled: August 14, 2003Date of Patent: August 11, 2009Assignee: TransMedic, Inc.Inventors: Waleed H. Hassanein, Richard L. Bringham, Ronald L. Taylor, Jr.
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Publication number: 20080234768Abstract: Electrode systems have been developed for use in perfusion systems to measure the electrical activity of an explanted heart and to provide defibrillation energy as necessary. The perfusion systems maintain the heart in a beating state at, or near, normal physiological conditions; circulating oxygenated, nutrient enriched perfusion fluid to the heart at or near physiological temperature, pressure and flow rate. These systems include a pair of electrodes that are placed epicardially on the right atrium and left ventricle of the explanted heart, as well as an electrode placed in the aortic blood path.Type: ApplicationFiled: July 6, 2007Publication date: September 25, 2008Applicant: TransMedics, IncInventors: Waleed Hassanein, Ahmed Elbetanony, Richard Bringham, Robert Havener, Vincent Lambert, Burt Ochs
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Publication number: 20080017194Abstract: The invention, in various embodiments, provides systems, methods and solutions using an organ ex vivo.Type: ApplicationFiled: April 19, 2007Publication date: January 24, 2008Applicant: TransMedics, IncInventors: Waleed Hassanein, Tamer Khayal, Robert Havener, Stanley Kyi, Ihab Fattah, Hesham Saleh, Jon Trachtenberg
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Publication number: 20070190636Abstract: The invention provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the invention relates to maintaining an organ ex-vivo at near-physiologic conditions.Type: ApplicationFiled: October 7, 2005Publication date: August 16, 2007Applicant: TransMedics, Inc.Inventors: Waleed Hassanein, Thomas Bishop, Richard Bringham, Giovanni Cecere, Robert Fishman, Larry Goff, Tamer Khayal, Stanley Kyi, Burt Ochs, Scott Newell, Ronald Taylor, Hassam Algamil, Robert Havner, Dmitri Menn
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Publication number: 20060292544Abstract: The invention, in various embodiments, provides systems, methods and solutions for perfusing an organ.Type: ApplicationFiled: October 7, 2005Publication date: December 28, 2006Applicant: TransMedics, Inc.Inventors: Waleed Hassanein, Paul Lezberg, Tamer Khayal