Abstract: The invention at hand describes a method for the cyclization of peptides and proteins in which linear thioesters serve as substrates. The cyclization is catalyzed by thioesterase domains of NRPS or PKS cyclases. The substrates according to the present invention are composed of one linear peptide on which a charge-stabilized aromatic, heteroaromatic or araliphatic leaving group is bound. These substrates lead to higher yields and reaction rates than linear peptides able to be cyclized with methods known so far and, furthermore, allow the cyclization of such peptides which were previously not able to be cyclized.

Abstract: The invention relates to an equine inhalation mask, comprising at least one valveless combined inhalation and exhalation conduit, into which inhalant sources comprising respiration control elements and an energy supply that does not require supply lines are interchangeably integrated. A filter system is mounted on the outer end of the inhalation and exhalation conduit facing away from the head of the horse. Said system and the fact that the mask is effectively sealed when on the head of the horse prevent any escape of the aerosol into the environment, thus permitting a reliable inhalation therapy lasting several minutes under normal respiratory conditions.

Abstract: In a method for influencing and measuring pulsed electromagnetic illumination, e.g. parallel laser light (L), said illumination or light can be spatially divided, in particular, in an autocorrelator comprising a beam receptor (12), can be recombined behind said beam receptor by a superposition or focusing device (18 or 58) and can be detected in the recombinant area by a detector (20). As the transmission system (52), the beam receptor comprises beam profile dividers in a penetrable housing (50), in the form of at least two transmission parts (54; 56), with or in which separate, preferably parallel component beams (S, T) can be modified in their time-based beam characteristics, before being recombined.