Abstract: The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders.

Abstract: The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders. The present disclosure relates to a non-toxic mutant form of the Vibrio cholera Cholix gene (ntCholix), a variant of Cholix truncated at amino acid A386 (Cholix386) and the use of other various Cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active therapeutics.

Abstract: The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders. The present disclosure relates to a non-toxic mutant form of the Vibrio cholera Cholix gene (ntCholix), a variant of Cholix truncated at amino acid A386 (Cholix386) and the use of other various Cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active therapeutics.

Abstract: A method for vehicle location preferably includes determining vehicle information, and can optionally include facilitating location of the vehicle. In variants, the method can guide the user to the general vehicle vicinity by presenting the user with an imprecise vehicle location, and locally guide the user to the vehicle using vehicle information.

Abstract: The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders. The present disclosure relates to a non-toxic mutant form of the Vibrio cholera Cholix gene (ntCholix), a variant of Cholix truncated at amino acid A386 (Cholix386) and the use of other various Cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active therapeutics.

Abstract: The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders. The present disclosure relates to a non-toxic mutant form of the Vibrio cholera Cholix gene (ntCholix), a variant of Cholix truncated at amino acid A386 (Cholix386) and the use of other various Cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active therapeutics.

Abstract: A mobile electronic device that is configured to display travel-related information is disclosed. In one or more implementations, the electronic device includes a touch-sensitive display, the touch-sensitive display configured to receive one or more inputs, a memory operable to store one or more modules, and a processor communicatively coupled to the touch-sensitive display and to the memory. The processor is operable to execute the one or more modules to cause display of one or more graphical representations of travel-related data at the touch-sensitive display. The processor is also operable to cause display of a telephonic communication graphical interface and to cause a telephonic communication link to be established with a travel representative of a travel management company in response to an input received over the telephonic communication graphical interface.

Abstract: Implementations of the accessory and associated methods allow for excavation of a ditch, wherein rotating grating means are used for expelling rubble and form a ditch. The accessory includes grating means which are moved with respect to the ditch to ensure contacting of the grating means with the road and alignment of a rotation axis of the grating means with the ditch axis. The ditch is progressively excavated when the grating means are rotated and displaced along the ditch axis. The grating means may be connectable to a mobile device through an arm assembly configured to controllably move the grating means from the mobile device. The accessory may be used for connection to a mining device for excavating the ditch along the road of an underground mining tunnel.

Abstract: An apparatus is described capable of use on smooth and rough terrains at both low and high speeds. The trailer apparatus has an auto leveling feature combined with uniform loading support that reduces torsional loading of the cargo. The invention also includes a trailer capable of travel at high speeds, which hydraulically equalizes distribution of the weight of the cargo. The invention further includes an easy lift tow bar, all axle steering, single tire axles, self-leveling and adjustable suspension, combination of air, anti-lock and electronic braking system, and ability to travel at high speed speeds with reduced system sway.

Abstract: A tension-adjusting tool includes a L-shaped rod composed of two segments. One segment is removably attached to a rocker on which the tensioning pulley of a diesel engine of a truck is mounted while the other segment has a tubular component in which a handle is removably accommodated. The handle has an upper portion which extends above the engine and which can be manipulated to activate the L-shaped rod in order to cause the rocker to pivot with resulting change in the pressure applied by the tensioning pulley.

Abstract: An apparatus and method is described for offsetting a lifting or lowering weight of a tow bar attached to a trailer. The apparatus includes nitrogen accumulators coupled in series to a hydraulic cylinder. The accumulators include volumes of hydraulic fluid and a gas, such as nitrogen, which are preset to have differing nitrogen pressures to accommodate a full range of motion. After initial system pressurization, no separate power source is needed to provide hydraulic support at static conditions, oscillation of the tow bar below horizontal, and lift support from horizontal to a positive angle, allowing the user to lift and position a heavy tow bar several feet with minor user force.

Abstract: An automatic management and control system for controlling a transport motored vehicle engine idle conditions, operation of vehicle accessories and engine controls when the vehicle is at a rest condition. This system has a controlled unit with a programmable computer having a memory for storing instructions for execution of an interactive management control program by the control unit. The control unit is conditioned by the operator of the vehicle to operate in a cabin heating mode or a cabin air-conditioning mode. The control unit is also conditioned by the control program to enable a defeat protection circuit to control a fast idle switch function in the cabin to prevent a vehicle operator person to attempt to override a idle shut-down mode of the control module when enabled for a set time period whereby to ensure autonomous automatic engine control by the control unit when the vehicle is in the rest condition with the control unit enabled to thereby optimize fuel efficiency.

Abstract: Disclosed herein is a method of detecting a microsleep event in a subject. The method includes determining a number of eye openness factors by measuring a number of distances between an upper eyelid and a lower eyelid of at least one eye over a time period. Graphical representations of the eye openness factors are then generated. Changes in the eye openness factors over the time period are correlated with a reference eye closure pattern indicative of the microsleep event. Also disclosed is a microsleep event detection device.

Abstract: The present invention provides a system and method for detecting collusion in online gaming involving a plurality of players, the method comprising storing game information data and game action data on every action in every game for every player in the online gaming database, performing a player action analysis of correlated actions between a pair of online game players and storing data from the player action analysis in a user action database, employing one or more Bayesian Network graphical models to determine a likelihood of conditional behavior between the pair of online game players, computing individual scores for the Bayesian Network graphical models and comparing the score of a collusional model with that of a non-collusional model.

Abstract: A collapsible assembly for loading and transporting vehicles in a cargo container having a roof, a floor, two elongate side walls, and front and rear walls, includes two pairs of spaced vertical posts, one pair being at the front end of the frame and another pair being at the rear end. Front and rear horizontally mounted crossbars support two ramps for carrying a vehicle when the assembly is in its open position. Each crossbar has two members of equal length rotatably and slideably attached to the posts and connected together by a hinge that allows each crossbar to be folded in half interiorly of the frame thus pulling the posts together in a collapsed closed position for storage purposes.

Abstract: A multi-lobed, low friction vane, thrust vector controller is disclosed. Low friction vanes are independently movable into and out of the thrust of the exhaust of a jet engine. All vanes may be used together to adjust exhaust surface area to maximize thrust and fuel efficiency in varying conditions. Vanes also move independently to impart directional force to roll, pitch and yaw traditional aircraft and hover VTOL aircraft. A bleed air pressure actuator for moving the vanes is disclosed.

Abstract: An outrigger assembly having a mounting portion mountable directly to a dump trailer suspension system. In one embodiment, the mounting portion is mounted directly to leaf springs of a suspension system. Two stabilizing arms are pivotably attached to the mounting portion. A driving mechanism is connected to the stabilizing arm and configured to move the stabilizing arms between an inward, stowed position, and an extended, stabilized position. The stabilizing arms being shaped and sized to engage the ground outboard of the dump trailer wheel base to increase the effective width of the dump trailer's support base, thereby stabilizing the dump trailer from tipping.

Abstract: In adapting a semi-trailer for hauling ATVs, modular track segments of a predetermined length for conveniently spanning a plurality of longitudinally spaced, transversely extending E-bars that attach to the logistic posts in the side wall of the semi-trailer are arranged to provide an elevated deck structure in the trailer on which additional ATVs can be placed. In order to load both the floor level and the elevated deck level, appropriately sized and configured ramps that extend from ground level to the trailer floor, or alternatively to the elevated deck structure, permit the ATVs to be driven onto the trailer floor or its elevated deck.

Abstract: In adapting a semi-trailer for hauling ATVs, modular track segments of a predetermined length for conveniently spanning a plurality of longitudinally spaced, transversely extending E-bars that attach to the logistic posts in the side wall of the semi-trailer are arranged to provide an elevated deck structure in the trailer on which additional ATVs can be placed. In order to load both the floor level and the elevated deck level, appropriately sized and configured ramps that extend from ground level to the trailer floor, or alternatively to the elevated deck structure, permit the ATVs to be driven onto the trailer floor or its elevated deck.