Abstract: The invention proposes a cell-free graft, comprising (i) a cohesive, structure-forming matrix with open porosity made from a biologically and pharmaceutically acceptable material and (ii) serum. In one particularly preferred embodiment, the matrix additionally contains a gel. By virtue of a second aspect, a method of producing such a cell-free graft is proposed, whereby the matrix and the gel, if one is provided, is placed in contact with the serum. The graft may optionally be dried with serum. Alternatively, the matrix and the gel, if one is provided, are in the dried state before being placed in contact with the serum. By virtue of a third aspect, finally, the invention proposes the use of the cell-free graft for regenerating tissue and in particular for regenerating cartilage and/or bone.
Type:
Application
Filed:
June 29, 2006
Publication date:
August 28, 2008
Applicant:
TRANSTISSUE TECHNOLOGIES GMBH
Inventors:
Michael Sittinger, Eszter Tanczos, Christian Kaps
Abstract: Implantable substrate for the healing and/or protection of connective tissue, preferably cartilage, comprising at least one composition for the activation of locally present cells for tissue regeneration and at least one structure for cell invasion in vivo and/or for the formation of cell matrix and/or for the release of constituents of the employed composition.
Type:
Application
Filed:
August 5, 2003
Publication date:
February 12, 2004
Applicant:
TRANSTISSUE TECHNOLOGIES, GmbH
Inventors:
Michael Sittinger, Olaf Schultz, Gerd-Rudiger Burmester
Abstract: Implantable substrate for the healing and/or protection of connecting tissue, preferably cartilage, comprising at least one composition for the activation of locally present cells for tissue regeneration and at least one structure for cell invasion in vivo and/or for the formation of cell matrix and/or for the release of constituents of the employed composition.
Type:
Grant
Filed:
November 22, 2000
Date of Patent:
August 5, 2003
Assignee:
TransTissue Technologies GmbH
Inventors:
Michael Sittinger, Olaf Schultz, Gerd-Rudiger Burmester