Abstract: A device for preparing a liquid sample for a direct injection of a corresponding gaseous sample to a micro-gas chromatograph includes: a fluid space and a gas space, which spaces are separated by a semipermeable separating layer, the fluid space including a supply line for the liquid sample, and the gas space having an outlet connectable with the gas chromatograph. The fluid space and/or the gas space is associated with at least one heating element. The device absorbs a sample volume of approximately 10 ?l to 30 ?l. The separating layer has a thickness of 10 ?l to 300 ?l and pores having a size between 0.05 ?l and 5 ?l.

Abstract: A stopcock manifold system includes: a manifold provided with one or several stopcocks, each having a rotary opening/closing control apparatus with at least one finger or crank pin; a rotary mechanized actuator coupling part for each manifold, a rotary axis of the coupling part corresponding in use to a rotation axis of the control apparatus, the coupling part coupling with the stopcock by insertion of each crank pin into a closed notch in the coupling part, the closed notch of each coupling part receiving one of the crank pins of the corresponding stopcock, such that the crank pin is insertable into the corresponding coupling part by tilting the manifold and then straightening it, until it abuts on a first bearing point comprised of an edge of the closed notch; and a maintaining system that enables each coupling part to individually maintain the corresponding stopcock in place.

Abstract: A perforating needle intended to be inserted into a flask through a stopper or septum to inject and remove a fluid includes a pointed end for piercing the stopper and a cylindrical body. The central body includes a central channel through which the fluid may enter and leave the flask and a side wall having at least one lateral orifice. The orifice is in fluid communication with the central channel. A lower end of the orifice is, in use, essentially level with an inner face of the stopper. The orifice is extended toward the pointed end by at least one slot, a shape of which is essentially tangential to a flow of the fluid so as to channel the fluid along an axis of the needle. The side wall includes at least two diametrically opposite lateral orifices arranged on either side of a central island.

Abstract: The present invention relates to a method for purification of 18F-labeled choline analogs in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (SPE) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18F-labeled choline analogs.

Abstract: The present invention relates to a method for stabilizing radiosynthetic intermediates used in synthesis of 18F radiolabeled aromatic amino acid derivatives toward decomposition caused by beta and gamma radiations by the use of radical scavengers and/or reductants and/or antioxidants.

Abstract: The present invention is related to a method to obtain reactive [18F] fluorides in an organic medium suitable for radiolabelling without any azeotropic evaporation step, by the use of a solid phase extraction column containing a modified non-ionic solid support.

Abstract: A method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step wherein the eluting solution is a organic solution having a water content <3%. The solution contains at least: an organic solvent suitable for the subsequent radiolabelling reaction; a first compound (A) which is a molecule containing at least one acidic hydrogen and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of the first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).

Abstract: A cartridge for radiopharmaceutical packaging includes a low UV-absorbing plastic barrel, closed at one end by a cap and at the other by a piston. A shoulder cooperates with the barrel in a double-level snap-on system with a cavity cooperating with an injection fitting sleeve to make a seal. At a first end the cap has a peel-off porous liner covering the cavity. Radial fins protrude inside the cavity, for screwing the injection fitting and second radial fins protrude outside of the cap to fix to a cartridge protection shield. A second end minimizes a shadow area of UV flash lamp sterilization and ensures clearance for inserting an injection spike. The second end has a reduced wall thickness pierced by the spike during set up for dispensing of the pharmaceutical. An external cylindrical zone at the second end ensures leak tightness between the cap and the barrel.

Abstract: A method extracts out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step. The eluting solution is a low water content, preferably <3% water, organic solution containing at least: a first compound (A) which is a tertiary alcohol-function bearing molecule, a second compound (B) which is a phase transfer agent suitable for radiolabeling and which is necessary to the anion exchange process.

Abstract: A cartridge for radiopharmaceutical packaging includes a low UV-absorbing plastic barrel, closed at one end by a cap and at the other by a piston. A shoulder cooperates with the barrel in a double-level snap-on system with a cavity cooperating with an injection fitting sleeve to make a seal. At a first end the cap has a peel-off porous liner covering the cavity. Radial fins protrude inside the cavity, for screwing the injection fitting and second radial fins protrude outside of the cap to fix to a cartridge protection shield. A second end minimizes a shadow area of UV flash lamp sterilization and ensures clearance for inserting an injection spike. The second end has a reduced wall thickness pierced by the spike during set up for dispensing of the pharmaceutical. An external cylindrical zone at the second end ensures leak tightness between the cap and the barrel.

Abstract: A method extracts out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step. The eluting solution is a low water content, preferably <3% water, organic solution containing at least: a first compound (A) which is a tertiary alcohol-function bearing molecule, a second compound (B) which is a phase transfer agent suitable for radiolabeling and which is necessary to the anion exchange process.

Abstract: The present invention is related to a method to obtain reactive [18F] fluorides in an organic medium suitable for radiolabelling without any azeotropic evaporation step, by the use of a solid phase extraction column containing a modified non-ionic solid support.

Abstract: A method to extract out of an aqueous solution, concentrate and/or reformulate [18F] fluorides without any evaporation step wherein the eluting solution is a organic solution having a water content <3%. The solution contains at least: an organic solvent suitable for the subsequent radiolabelling reaction; a first compound (A) which is a molecule containing at least one acidic hydrogen and a second compound (B) which is an organic base sufficiently strong to be able to tear off the acidic hydrogen of the first compound (A) in an acid-base reaction leading to the formation of an organic salt (S).

Abstract: A method to extract out of water, concentrate and reformulate [18F] fluorides includes passing a dilute aqueous [18F] fluoride solution entering by an inlet (1) in a cavity (6) embodying an electrochemical cell with at least two electrodes (3, 4, 5), flowing in the cavity (6) and coming out of the cavity (6) by an outlet (2), an external voltage being applied to the electrodes. One electrode (4) is used as an extraction electrode, another one (3) is used for polarizing the solution, and configured so that at least the extraction electrode (4), either used as a cathode or as an anode, is in contact with and polarizes a large specific surface area conducting material (7), contained in the cavity (6). The extracted ions are released from the surface of the large specific surface area conducting material (7) by turning off the applied external voltage.