Patents Assigned to Trent University
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Patent number: 12181427Abstract: A sample inspection system (100) includes an X-ray emitter, a collimator (170) and a first energy resolving detector (180) arranged along a symmetry axis (105). The X-ray emitter generates at least one focused conical shell beam (150) of X-ray radiation comprised of X-ray photons that propagate through a focal point on the symmetry axis downstream of the X-ray emitter. The collimator (170) has one or more channels, each channel being adapted to receive diffracted or scattered radiation propagating either along the symmetry axis, or parallel with the symmetry axis, or both along and parallel with the symmetry axis (105). Upon incidence of the conical shell beam (150) onto a sample (106) the first energy resolving detector (180) detects radiation diffracted or scattered by the sample (106) via the collimator (170).Type: GrantFiled: December 13, 2022Date of Patent: December 31, 2024Assignees: The Nottingham Trent University, Cranfield UniversityInventors: Paul Evans, Keith Rogers
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Publication number: 20240390203Abstract: A patient table includes a patient support surface for supporting a patient and a pressure redistribution assembly that includes a pressure sensing assembly and a repositioning assembly. The pressure sensing assembly measures a pressure between the patient support surface and a patient at a plurality of sensing regions. The repositioning assembly includes a plurality of inflatable cells overlapping the plurality of sensing regions. A medium is located within the inflatable cells and an actuator selectively redistributes a quantity of the medium between the inflatable cells. A processor is configured to receive a measurement of the pressure from the pressure sensing assembly, determine if the measurement of pressure is above a threshold and, if the measurement of pressure is above the threshold, generate a signal to redistribute the medium.Type: ApplicationFiled: May 22, 2024Publication date: November 28, 2024Applicants: Baxter Medical Systems GmbH + Co. KG, Nottingham Trent UniversityInventors: Heinz-Hermann Dalbert, Steffen Löser, Nicolette D. Sizer, Julia Sabrina Fleischer, Pascal Stark, Philip Breedon, Bronek Boszczyk
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Patent number: 11726048Abstract: A sample inspection apparatus includes a source of electromagnetic radiation, a beam former for producing a plurality of coaxial and substantially conical shells of radiation, a detection surface and a set of conical shell slot collimators. Each conical shell has a different opening angle. The detection surface is arranged to receive diffracted radiation after incidence of one or more of the conical shells upon the sample to be inspected. The set of conical shell slot collimators is provided at or close to the detection surface which each stare at different annular regions of different corresponding conical shells.Type: GrantFiled: September 15, 2022Date of Patent: August 15, 2023Assignees: The Nottingham Trent University, The Cranfield UniversityInventors: Paul Evans, Keith Rogers
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Publication number: 20230220087Abstract: The present invention is directed to a method of treating a hematologic malignancy such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), including hematologic malignancies that are refractive to chemotherapeutic and/or hypomethylating agents. The method concerns administering a CD123×CD3 bispecific binding molecule to a patient in an amount effective to stimulate the killing of cells of said hematologic malignancy in said patient. The present invention is particularly directed to the embodiment of such method in which a cellular sample (Z from the patient prior to such administration evidences an expression of one or more target genes that is increased relative to a baseline level of expression of such genes, for example, a baseline level of expression of such genes in a reference population of individuals who are suffering from the hematologic malignancy, or with respect to the level of expression of a reference gene.Type: ApplicationFiled: June 9, 2021Publication date: July 13, 2023Applicants: MacroGenics, Inc., Nottingham Trent UniversityInventors: Jan Kenneth Davidson, Sergio Rutella
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Patent number: 11624717Abstract: There is presented an apparatus for identifying a sample. Such an apparatus may be used to detect unwanted items as part of a security screening system. The apparatus includes a platform for receiving the sample, at least one electromagnetic radiation emitter, a plurality of detectors and a calculator. The electromagnetic radiation emitter is adapted to provide a plurality of conical shells of radiation. Each conical shell has a characteristic propagation axis associated with it. The detectors are arranged to detect radiation diffracted by the sample upon incidence of one or more conical shells of radiation. Each detector is located on the characteristic propagation axis associated with a corresponding conical shell. The calculator is adapted to calculate a parameter of the sample based on the detected diffracted radiation. The parameter includes a lattice spacing of the sample.Type: GrantFiled: July 10, 2019Date of Patent: April 11, 2023Assignees: The Nottingham Trent University, Cranfield UniversityInventors: Paul Evans, Keith Rogers
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Patent number: 11467104Abstract: A sample inspection apparatus includes a source of electromagnetic radiation, a beam former for producing a substantially conical shell of the radiation with the conical shell being incident on a sample to be inspected, a detection surface arranged to receive diffracted radiation after incidence of the conical shell beam upon the sample to be inspected, and an unfocused collimator provided at or close to the detection surface and having a grid structure formed of cells which each stare at different portions of the conical shell.Type: GrantFiled: February 19, 2021Date of Patent: October 11, 2022Assignees: The Nottingham Trent University, Cranfield UniversityInventors: Paul Evans, Keith Rogers
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Publication number: 20210395374Abstract: The present invention is directed to a method of treating a hematologic malignancy such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), including hematologic malignancies that are refractive to chemotherapeutic and/or hypomethylating agents. The method concerns administering a CD123×CDS bispecific binding molecule to a patient in an amount effective to stimulate the killing of cells of said hematologic malignancy in said patient. The present invention is additionally directed to the embodiment of such method in which a cellular sample from the patient evidences an expression of one or more target genes that is increased relative to a baseline level of expression of such genes, for example, a baseline level of expression of such genes in a reference population of individuals who are suffering from the hematologic malignancy, or with respect to the level of expression of a reference gene.Type: ApplicationFiled: October 29, 2019Publication date: December 23, 2021Applicants: MacroGenics, Inc., NanoString Technologies, Inc., Nottingham Trent UniversityInventors: Jan Kenneth Davidson, Sara Church, Sergio Rutella
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Patent number: 11078600Abstract: In a method of electrospinning nanofibres, a non-conductive laminate fibre collection structure (22) is placed on the surface of a conductive collector (18, FIG. 1). The laminate structure has a base layer (26) proximal to the collector and a fibre support layer (24). A pair of spaced first apertures (32) and a second aperture (34) located between them are defined through the fibre support layer (24). A pair of spaced third apertures (38) are defined through the base layer (26), each third aperture being aligned with one of the first apertures to define an opening (40) through the laminate structure. During electro spinning, the fibre is attracted to one of the openings (40) where it forms a bridge across the respective first aperture (32). A charge in the collected fibre builds up until the fibre is repelled and it moves to the nearest lowest potential region which is the second opening on the opposite side of the second aperture (34).Type: GrantFiled: August 31, 2017Date of Patent: August 3, 2021Assignee: Nottingham Trent UniversityInventors: Robert Stevens, Joseph Chemmarappally
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Patent number: 10948432Abstract: A sample inspection apparatus irradiates a sample with a conical shell of X-ray or similar radiation generating a plurality of Debye rings originating from a circular path on the sample. The apparatus is provided with two detectors. A first detector receives diffracted radiation and a second detector receives radiation which is transmitted through a coded aperture provided at a detection surface of the first detector.Type: GrantFiled: August 23, 2019Date of Patent: March 16, 2021Assignees: The Nottingham Trent University, Cranfield UniversityInventors: Paul Evans, Keith Rogers
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Patent number: 10738251Abstract: This present disclosure relates to biodiesel compositions comprising polymeric pour point depressants, and crystallization modifiers, to improve cold flow properties for biodiesel fuels.Type: GrantFiled: November 4, 2016Date of Patent: August 11, 2020Assignee: Trent UniversityInventors: Suresh Narine, Laziz Bouzidi, Athira Mohanan
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Patent number: 10604712Abstract: This application relates to phase behaviors of certain triacylglycerols and fatty acid methyl esters, and how the phase behaviors of these individual components in a biodiesel fuel, as well as their combined mixtures, helps understand the fundamental mechanisms of their crystallization so as to design biodiesel fuels with improved low temperature characteristics.Type: GrantFiled: April 15, 2013Date of Patent: March 31, 2020Assignee: Trent UniversityInventors: Suresh Narine, Laziz Bouzidi, Bruce Darling, Mark Baker, Shaojun Li, Ali Mahdevari
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Patent number: 10457562Abstract: The present disclosure relates to anti-corrosion sol-gel material. In particular, the disclosure relates to a cross-linked sol-gel material comprising a first colloidal sol gel made from silanols having an epoxy functionality and a second colloidal sol gel made from silanols having a thiol functionality.Type: GrantFiled: March 15, 2016Date of Patent: October 29, 2019Assignee: Trent UniversityInventors: Andrew James Vreugdenhil, Theresa Elizabeth Stotesbury
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Patent number: 10316235Abstract: A container for a food and/or beverages is provided. The container is designed such that it may have the capability of absorbing excess thermal energy from the food or beverage, thereby cooling the consumable material to a desired temperature and maintaining the material at the desired temperature for a considerable period of time. The container typically includes an outer insulating shell; an inner heat conducting liner and a phase change material (PCM). To facilitate heat transfer to and from a food or beverage stored in the container, the PCM is commonly disposed between the outer insulating shell and the inner heat conducting liner and positioned in thermal contact with the inner heat conducting liner. The PCM may include a diol diester having a melting point of about 30 to 90° C.Type: GrantFiled: January 26, 2015Date of Patent: June 11, 2019Assignee: Trent UniversityInventors: Suresh S. Narine, Michael C. Floros, Michael Tessier
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Patent number: 10317580Abstract: A thin film comprising a layer of dielectric material having electrically conductive inclusions, wherein the thin film has a first reflectivity due to surface plasmon resonance, and wherein the thin film is configured to provide one or more selected regions having a second reflectivity due to surface plasmon resonance.Type: GrantFiled: August 8, 2012Date of Patent: June 11, 2019Assignee: Nottingham Trent UniversityInventors: Demosthenes Koutsogeorgis, Panos Patsalas, Elefterios Lidorikis, Wayne Cranton
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Patent number: 10301751Abstract: An electronically functional yarn comprises a plurality of carrier fibers (6) forming a core with a series of electronic devices (2) mounted on the core with conductive interconnects (8) extending along the core. A plurality of packing fibers (10) are disposed around the core, the devices and the interconnects, and a retaining sleeve (12) is disposed around the packing fibers. The core, the devices and the interconnects are confined within the plurality of packing fibers retained in the sleeve. In the manufacture of the yarn the electronic devices with interconnects coupled thereto in sequence are mounted on the core; the carrier fibers with the mounted devices and interconnects are fed centrally through a channel with packing fibers around the sides thereof to form a fiber assembly around the core, which is fed into a sleeve forming unit in which a sleeve is formed around the assembly to form the composite yarn.Type: GrantFiled: September 4, 2015Date of Patent: May 28, 2019Assignee: Nottingham Trent UniversityInventors: Tilak Kithsiri Dias, Anura Rathnayake
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Patent number: 10294861Abstract: Compressed gas energy storage systems, which include an integrated thermal energy storage component, are provided. The systems include a compression stage, a heat transfer unit, and a gas storage reservoir, serially linked in fluid communication. The system may include one, two, or three compression stages and heat transfer units. Each heat transfer unit may include two or more thermal energy storage stages. Each thermal energy storage stage may include one or more phase change materials. A method of storing compressed gas energy, which includes compressing a gas through a compression stage to produce a compressed gas; passing the compressed gas through a heat transfer unit to produce a heat removed gas; and transferring the heat removed gas to a gas storage reservoir.Type: GrantFiled: January 26, 2015Date of Patent: May 21, 2019Assignee: Trent UniversityInventors: Suresh S. Narine, Michael Tessier
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Patent number: 10257191Abstract: Methods and apparatuses for providing biometric authentication of a test user using a registration process where a reference data sample representative of one or more biometric attributes of a reference user is used to train a plurality of neural networks to achieve a target output. The weights that achieve this in the plurality of neural networks may be stored on a user device as a first data set. A second data set representative of one or more biometric attributes may be obtained from the test user using the authentication device or received from the user device. The first data set may be received by the authentication device and used as weights in an artificial neural network and the second data set may be used as inputs. The output of the neural network may determine a degree of correlation between the reference user and the test user to be authenticated.Type: GrantFiled: March 29, 2016Date of Patent: April 9, 2019Assignee: Nottingham Trent UniversityInventors: Tony John Allen, Sergio Grau Puerto
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Patent number: 10154628Abstract: The invention relates to methods of forming coated metal oxide particles, suspensions of such coated particles, particles comprising functionalized surface coatings and to fortification of food crops with coated metal oxide particles. Embodiments disclosed include a method of fortifying a food crop with a trace element, the method comprising growing the food crop in a growth medium comprising the trace element in the form of metal oxide particles coated with an organic compound, and a food crop fortified with a trace element in the form of metal oxide particles. Also disclosed is a method of forming coated particles, the method comprising: providing a first quantity of metal oxide particles; providing a second quantity of a coating material comprising an organic compound; and mechanically mixing the metal oxide particles with the coating material in a dry mixing process to provide a mixture comprising the metal oxide particles coated with the organic compound.Type: GrantFiled: March 15, 2013Date of Patent: December 18, 2018Assignee: The Nottingham Trent UniversityInventors: Gareth Wynn Vaughan Cave, Victoria Jane Mundell
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Patent number: 10137185Abstract: The application provides a polypeptide comprising the sequence SLMTNLAAL (SEQ ID NO: 8), Ser 13 to Leu 21 of amino acid sequence shown in FIG. 1 or SEQ ID No 1, and having HLA-A2 haplotype binding activity, or a polynucleotide encoding said polypeptide. Vaccines containing the polypeptide or polynucleotides encoding the polypeptide are also provided.Type: GrantFiled: April 9, 2015Date of Patent: November 27, 2018Assignee: Nottingham Trent UniversityInventors: McArdle Stephanie, Rees Robert, A. Graham Pockley, Jaimy Saif
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Patent number: 10125337Abstract: The disclosure generally provides branched diester compounds having exceptional low-temperature and flow properties. The disclosure also provides uses of the branched diester compounds in lubricant compositions, for example, as a base oil, and in other applications where their low-temperature and flow properties can be employed beneficially. The disclosure also provides efficient and green methods for making the branched diester compounds.Type: GrantFiled: November 16, 2016Date of Patent: November 13, 2018Assignee: Trent UniversityInventors: Suresh Narine, Laziz Bouzidi, Latchmi Raghunanan