Abstract: An antibody or antigen-binding fragment that binds human endothelial protein C receptor (hEPCR) and neutralizes, reduces or interferes with at least one activity of hEPCR, in which (a) the antibody or antigen-binding fragment has a heavy chain variable region (HCVR) with at least 80% identity to a sequence selected from SEQ ID NO: 1, 3, 5 and 7, and/or a light chain variable region (LCVR) with at least 80% identity to a sequence selected from SEQ ID NO: 2, 4, 6 and 8, and/or (b) the antibody or antigen-binding fragment has a heavy chain variable region (HCVR) selected from SEQ ID NO: 1, 3, 5 and 7 with 10 or fewer conservative amino acid substitutions and/or a light chain variable region (LCVR) selected from SEQ ID NO: 2, 4, 6 and 8 with 10 or fewer conservative amino acid substitutions, is disclosed.

Abstract: A sample inspection system (100) includes an X-ray emitter, a collimator (170) and a first energy resolving detector (180) arranged along a symmetry axis (105). The X-ray emitter generates at least one focused conical shell beam (150) of X-ray radiation comprised of X-ray photons that propagate through a focal point on the symmetry axis downstream of the X-ray emitter. The collimator (170) has one or more channels, each channel being adapted to receive diffracted or scattered radiation propagating either along the symmetry axis, or parallel with the symmetry axis, or both along and parallel with the symmetry axis (105). Upon incidence of the conical shell beam (150) onto a sample (106) the first energy resolving detector (180) detects radiation diffracted or scattered by the sample (106) via the collimator (170).

Abstract: A sample inspection system (100) includes an X-ray emitter, a collimator (170) and a first energy resolving detector (180) arranged along a symmetry axis (105). The X-ray emitter generates at least one focused conical shell beam (150) of X-ray radiation comprised of X-ray photons that propagate through a focal point on the symmetry axis downstream of the X-ray emitter. The collimator (170) has one or more channels, each channel being adapted to receive diffracted or scattered radiation propagating either along the symmetry axis, or parallel with the symmetry axis, or both along and parallel with the symmetry axis (105). Upon incidence of the conical shell beam (150) onto a sample (106) the first energy resolving detector (180) detects radiation diffracted or scattered by the sample (106) via the collimator (170).

Abstract: A patient table includes a patient support surface for supporting a patient and a pressure redistribution assembly that includes a pressure sensing assembly and a repositioning assembly. The pressure sensing assembly measures a pressure between the patient support surface and a patient at a plurality of sensing regions. The repositioning assembly includes a plurality of inflatable cells overlapping the plurality of sensing regions. A medium is located within the inflatable cells and an actuator selectively redistributes a quantity of the medium between the inflatable cells. A processor is configured to receive a measurement of the pressure from the pressure sensing assembly, determine if the measurement of pressure is above a threshold and, if the measurement of pressure is above the threshold, generate a signal to redistribute the medium.

Abstract: A sample inspection system contains a source of electromagnetic radiation and an apparatus that includes a beam former, a collimator and an energy resolving detector. The beam former is adapted to receive electromagnetic radiation from the source to provide a polygonal shell beam formed of at least three walls of electromagnetic radiation. The collimator has a plurality of channels adapted to receive diffracted or scattered radiation at an angle. The energy resolving detector is arranged to detect radiation diffracted or scattered by a sample upon incidence of the polygonal shell beam onto the sample and transmitted by the collimator.

Abstract: A sample inspection apparatus includes a source of electromagnetic radiation, a beam former for producing a plurality of coaxial and substantially conical shells of radiation, a detection surface and a set of conical shell slot collimators. Each conical shell has a different opening angle. The detection surface is arranged to receive diffracted radiation after incidence of one or more of the conical shells upon the sample to be inspected. The set of conical shell slot collimators is provided at or close to the detection surface which each stare at different annular regions of different corresponding conical shells.

Abstract: The present invention is directed to a method of treating a hematologic malignancy such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), including hematologic malignancies that are refractive to chemotherapeutic and/or hypomethylating agents. The method concerns administering a CD123×CD3 bispecific binding molecule to a patient in an amount effective to stimulate the killing of cells of said hematologic malignancy in said patient. The present invention is particularly directed to the embodiment of such method in which a cellular sample (Z from the patient prior to such administration evidences an expression of one or more target genes that is increased relative to a baseline level of expression of such genes, for example, a baseline level of expression of such genes in a reference population of individuals who are suffering from the hematologic malignancy, or with respect to the level of expression of a reference gene.

Abstract: There is presented an apparatus for identifying a sample. Such an apparatus may be used to detect unwanted items as part of a security screening system. The apparatus includes a platform for receiving the sample, at least one electromagnetic radiation emitter, a plurality of detectors and a calculator. The electromagnetic radiation emitter is adapted to provide a plurality of conical shells of radiation. Each conical shell has a characteristic propagation axis associated with it. The detectors are arranged to detect radiation diffracted by the sample upon incidence of one or more conical shells of radiation. Each detector is located on the characteristic propagation axis associated with a corresponding conical shell. The calculator is adapted to calculate a parameter of the sample based on the detected diffracted radiation. The parameter includes a lattice spacing of the sample.

Abstract: A sample inspection apparatus includes a source of electromagnetic radiation, a beam former for producing a plurality of coaxial and substantially conical shells of radiation, a detection surface and a set of conical shell slot collimators. Each conical shell has a different opening angle. The detection surface is arranged to receive diffracted radiation after incidence of one or more of the conical shells upon the sample to be inspected. The set of conical shell slot collimators is provided at or close to the detection surface which each stare at different annular regions of different corresponding conical shells.

Abstract: A sample inspection system contains a source of electromagnetic radiation and an apparatus that includes a beam former, a collimator and an energy resolving detector. The beam former is adapted to receive electromagnetic radiation from the source to provide a polygonal shell beam formed of at least three walls of electromagnetic radiation. The collimator has a plurality of channels adapted to receive diffracted or scattered radiation at an angle. The energy resolving detector is arranged to detect radiation diffracted or scattered by a sample upon incidence of the polygonal shell beam onto the sample and transmitted by the collimator.

Abstract: A sample inspection apparatus includes a source of electromagnetic radiation, a beam former for producing a substantially conical shell of the radiation with the conical shell being incident on a sample to be inspected, a detection surface arranged to receive diffracted radiation after incidence of the conical shell beam upon the sample to be inspected, and an unfocused collimator provided at or close to the detection surface and having a grid structure formed of cells which each stare at different portions of the conical shell.

Abstract: An antibody or antigen-binding fragment that binds human endothelial protein C receptor (hEPCR) and neutralizes, reduces or interferes with at least one activity of hEPCR, in which (a) the antibody or antigen-binding fragment has a heavy chain variable region (HCVR) with at least 80% identity to a sequence selected from SEQ ID NO: 1, 3, 5 and 7, and/or a light chain variable region (LCVR) with at least 80% identity to a sequence selected from SEQ ID NO: 2, 4, 6 and 8, and/or (b) the antibody or antigen-binding fragment has a heavy chain variable region (HCVR) selected from SEQ ID NO: 1, 3, 5 and 7 with 10 or fewer conservative amino acid substitutions and/or a light chain variable region (LCVR) selected from SEQ ID NO: 2, 4, 6 and 8 with 10 or fewer conservative amino acid substitutions, is disclosed.

Abstract: The present invention is directed to a method of treating a hematologic malignancy such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), including hematologic malignancies that are refractive to chemotherapeutic and/or hypomethylating agents. The method concerns administering a CD123×CDS bispecific binding molecule to a patient in an amount effective to stimulate the killing of cells of said hematologic malignancy in said patient. The present invention is additionally directed to the embodiment of such method in which a cellular sample from the patient evidences an expression of one or more target genes that is increased relative to a baseline level of expression of such genes, for example, a baseline level of expression of such genes in a reference population of individuals who are suffering from the hematologic malignancy, or with respect to the level of expression of a reference gene.

Abstract: There is presented an apparatus for identifying a sample. Such an apparatus may be used to detect unwanted items as part of a security screening system. The apparatus includes a platform for receiving the sample, at least one electromagnetic radiation emitter, a plurality of detectors and a calculator. The electromagnetic radiation emitter is adapted to provide a plurality of conical shells of radiation. Each conical shell has a characteristic propagation axis associated with it. The detectors are arranged to detect radiation diffracted by the sample upon incidence of one or more conical shells of radiation. Each detector is located on the characteristic propagation axis associated with a corresponding conical shell. The calculator is adapted to calculate a parameter of the sample based on the detected diffracted radiation. The parameter includes a lattice spacing of the sample.

Abstract: In a method of electrospinning nanofibres, a non-conductive laminate fibre collection structure (22) is placed on the surface of a conductive collector (18, FIG. 1). The laminate structure has a base layer (26) proximal to the collector and a fibre support layer (24). A pair of spaced first apertures (32) and a second aperture (34) located between them are defined through the fibre support layer (24). A pair of spaced third apertures (38) are defined through the base layer (26), each third aperture being aligned with one of the first apertures to define an opening (40) through the laminate structure. During electro spinning, the fibre is attracted to one of the openings (40) where it forms a bridge across the respective first aperture (32). A charge in the collected fibre builds up until the fibre is repelled and it moves to the nearest lowest potential region which is the second opening on the opposite side of the second aperture (34).

Abstract: A sample inspection apparatus includes a source of electromagnetic radiation, a beam former for producing a substantially conical shell of the radiation with the conical shell being incident on a sample to be inspected, a detection surface arranged to receive diffracted radiation after incidence of the conical shell beam upon the sample to be inspected, and an unfocused collimator provided at or close to the detection surface and having a grid structure formed of cells which each stare at different portions of the conical shell.

Abstract: A sample inspection apparatus irradiates a sample with a conical shell of X-ray or similar radiation generating a plurality of Debye rings originating from a circular path on the sample. The apparatus is provided with two detectors. A first detector receives diffracted radiation and a second detector receives radiation which is transmitted through a coded aperture provided at a detection surface of the first detector.

Abstract: The invention relates to an apparatus and methods for producing liquid colloids such as suspensions of nanoparticles, in which liquid feedstock materials are reacted on a reaction surface of a rotatable plate. The apparatus has a first plate (101) mounted for rotation about a rotation axis (102), the first plate (101) providing a reaction surface (103) having a concave portion; first (106) and second (107) inlet lines arranged to introduce respective first and second liquid feedstock materials to the reaction surface (103); and a collection unit (110) arranged to collect a reaction product formed from reaction of the liquid feedstock materials as a liquid colloid ejected from an outer edge of the plate (101).

Abstract: There has been a recent shift in cancer therapy from one size fits all to a personalized and tailored treatment for individual patients to increase efficiency and avoid unnecessary toxicity. This invention relates to a method of determining the prognosis and suitable treatment of cancer in a subject by measuring the level of expression of SPAG5. In particular, it relates to a method where high expression of SPAG5 in tumour cells correlates with aggressive tumours.

Abstract: This present disclosure relates to biodiesel compositions comprising polymeric pour point depressants, and crystallization modifiers, to improve cold flow properties for biodiesel fuels.