Patents Assigned to Trevena, Inc.
  • Opioid receptor ligands and methods of using and making same
    Patent number: 11931350
    Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
    Type: Grant
    Filed: July 2, 2021
    Date of Patent: March 19, 2024
    Assignee: TREVENA, INC.
    Inventors: Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C. K. Yuan
  • 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
    Patent number: 11912713
    Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: February 27, 2024
    Assignee: Trevena, Inc.
    Inventors: Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C. K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero
  • Compounds for modulating S1P1 activity and methods of using the same
    Patent number: 11912693
    Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of S1P1 receptor and methods of using the same.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: February 27, 2024
    Assignee: TREVENA, INC.
    Inventors: Philip Michael Pitis, Robert Eugene Boyd, Tamara Ann Miskowski Daubert, Michael John Hawkins, Guodong Liu, Aimee Crombie Speerschneider
  • Compounds and methods of preparing compounds S1P1 modulators
    Patent number: 11884655
    Abstract: The present embodiments are directed, in part, to processes and compositions that can, for example, be used in the preparation compounds of Formula (I), or a pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: January 30, 2024
    Assignee: Trevena, Inc.
    Inventors: Brian H. Heasley, Jennifer Wilent, Patrick J. Koestler
  • 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
    Patent number: 11702408
    Abstract: The present embodiments are directed, in part, to 5-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, such as those of Formula I, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinson's Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: July 18, 2023
    Assignee: TREVENA, INC.
    Inventors: Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C. K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero
  • 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
    Patent number: 11465980
    Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: October 11, 2022
    Assignee: TREVENA, INC.
    Inventors: Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C. K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero, Gregory J. Pacofsky
  • 7-membered aza-heterocyclic containing ?-opioid receptor modulating compounds, methods of using and making the same
    Patent number: 11225487
    Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
    Type: Grant
    Filed: February 15, 2018
    Date of Patent: January 18, 2022
    Assignee: Trevena, Inc.
    Inventors: Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C. K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero
  • Opioid receptor ligands and methods of using and making same
    Patent number: 11077098
    Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: August 3, 2021
    Assignee: Trevena, Inc.
    Inventors: Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C. K. Yuan
  • Methods of treating hyperalgesia
    Patent number: 10588889
    Abstract: This application describes compounds and methods that can be used to treat, reverse, or avoid hyperalgesia.
    Type: Grant
    Filed: December 14, 2016
    Date of Patent: March 17, 2020
    Assignee: TREVENA, INC.
    Inventors: Conrad Cowan, Michael Koblish, Michael W. Lark
  • Opioid receptor ligands and methods of using and making same
    Patent number: 10588898
    Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
    Type: Grant
    Filed: July 25, 2019
    Date of Patent: March 17, 2020
    Assignee: TREVENA, INC.
    Inventors: Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C. K. Yuan
  • 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same
    Patent number: 10246436
    Abstract: The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.
    Type: Grant
    Filed: August 30, 2016
    Date of Patent: April 2, 2019
    Assignee: TREVENA, INC.
    Inventors: Aimee Crombie Speerschneider, Dennis Shinji Yamashita, Philip Michael Pitis, Michael John Hawkins, Guodong Liu, Tamara Ann Miskowski Daubert, Catherine C. K. Yuan, Robert Borbo Kargbo, Robert Jason Herr, Donna Romero, Gregory J. Pacofsky
  • Opioid receptor ligands and methods of using and making same
    Patent number: 9849119
    Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: December 26, 2017
    Assignee: TREVENA, INC.
    Inventors: Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C. K. Yuan
  • Synthesis of beta-arrestin effectors
    Patent number: 9611293
    Abstract: Embodiments disclosed herein provide compounds and methods for preparing Beta-Arrestin Effectors.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: April 4, 2017
    Assignee: Trevena, Inc.
    Inventors: Nhut K. Diep, Yuriy Kalyan, Graham Lawton, Matthew Ronsheim, Shao Hong Zhou, Saibaba Racha
  • Beta-arrestin effectors and compositions and methods of use thereof
    Patent number: 9534017
    Abstract: This application describes a family of compounds acting as ?-arrestin effectors. Such compounds may provide significant therapeutic benefit in the treatment of chronic and acute cardiovascular diseases.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: January 3, 2017
    Assignee: Trevena, Inc.
    Inventors: Dennis Yamashita, Xiao-Tao Chen
  • Crystalline and amorphous forms of a ?-arrestin effector
    Patent number: 9518086
    Abstract: The present disclosure provides novel crystalline forms of a compound that acts as a ?-arrestin effector, processes for preparing novel crystalline and amorphous forms of a compound that acts as a ?-arrestin effector and uses thereof.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: December 13, 2016
    Assignee: Trevena, Inc.
    Inventors: Ritesh Sanghvi, Gregory Alcorn, Graham Richard Lawton, Meiki Yu, Matthew Ronsheim, Jiaher Tian, Shao Hong Zhou, Yuriy B. Kalyan
  • Opioid receptor ligands and methods of using and making same
    Patent number: 9309234
    Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: April 12, 2016
    Assignee: Trevena, Inc.
    Inventors: Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C. K. Yuan
  • Opioid receptor ligands and methods of using and making same
    Patent number: 9044469
    Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
    Type: Grant
    Filed: August 12, 2013
    Date of Patent: June 2, 2015
    Assignee: Trevena, Inc.
    Inventors: Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C. K. Yuan
  • ?-arrestin effectors and compositions and methods of use thereof
    Patent number: 8993511
    Abstract: This application describes a family of compounds acting as ?-arrestin effectors. Such compounds may provide significant therapeutic benefit in the treatment of chronic and acute cardiovascular diseases.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: March 31, 2015
    Assignee: Trevena, Inc.
    Inventors: Dennis Yamashita, Xiao-Tao Chen
  • Beta-arrestin effectors and compositions and methods of use thereof
    Patent number: 8946142
    Abstract: This application describes compounds acting as, for example, ?-arrestin effectors and uses thereof, in, for example, the treatment of chronic and acute cardiovascular diseases.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: February 3, 2015
    Assignee: Trevena, Inc.
    Inventors: Dennis Yamashita, Xiao Tao Chen
  • Opioid receptor ligands and methods of using and making same
    Patent number: 8835488
    Abstract: This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: September 16, 2014
    Assignee: Trevena, Inc.
    Inventors: Dennis Yamashita, Dimitar Gotchev, Philip Pitis, Xiao-Tao Chen, Guodong Liu, Catherine C. K. Yuan