Abstract: The present invention relates to a deinking composition and a method of deinking wastepaper by using a mixture of enzymes that act on constituents of all three waste paper components involved in ink retention on final pulp. The first component represents substrates located on the surface and in the internal waste paper structure. The second component represents substrates located in the interface between paper and ink, usually formed by coatings or size-press (starch containing or not) applied layers. The third component represents substrates located in the ink and/or toner compounds. This method provides improved performance in relation to conventional methods, or current deinking with enzymes, which acts on a limited number of substrates involved in ink retention on final pulp.