Abstract: Disclosed are methods and compositions for the treatment of autism spectrum disorder, related disorders and symptoms of such disorders, comprising co-administration of an oxytocin peptide and magnesium ions. Co-administration of an oxytocin peptide and magnesium ions results in a synergistic or enhanced effect on reducing social and communication deficits in a patient suffering from an autism spectrum disorder.
Abstract: Disclosed are magnesium-containing oxytocin peptide formulations or compositions comprising an oxytocin peptide and a magnesium salt that produces synergistic analgesia when used in treating pain. Also disclosed are methods for the treatment of pain (such as migraine headache) comprising co-administration of an oxytocin peptide and a magnesium salt.
Type:
Application
Filed:
January 7, 2016
Publication date:
December 28, 2017
Applicant:
Trigemina, Inc.
Inventors:
David C. YEOMANS, Dean CARSON, Ramachandran THIRUCOTE
Abstract: Disclosed are magnesium-containing oxytocin peptide formulations or compositions comprising an oxytocin peptide and a magnesium salt that produces synergistic analgesia when used in treating pain. Also disclosed are methods for the treatment of pain (such as migraine headache) comprising co-administration of an oxytocin peptide and a magnesium salt.
Type:
Grant
Filed:
January 7, 2016
Date of Patent:
April 25, 2017
Assignee:
TRIGEMINA, INC.
Inventors:
David C. Yeomans, Dean Carson, Ramachandran Thirucote
Abstract: The present invention relates to methods for the treatment of headache and headache disorders. The methods comprise administration of an oxytocin peptide for the treatment of primary and secondary headaches or trigeminal neuralgia.
Type:
Grant
Filed:
May 24, 2012
Date of Patent:
August 6, 2013
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Trigemina, Inc., HealthPartners Research & Education
Inventors:
David C. Yeomans, Martin S. Angst, William H. Frey, II, Daniel I. Jacobs
Abstract: The invention provides for methods and compositions for treatment of pain via craniofacial mucosal administration of an analgesic compound (e.g. a non-opioid analgesic peptide, an NOP agonist or N/OFQ). Intranasal administration of certain analgesic peptides such as N/OFQ results in global analgesic effects.
Abstract: The present invention relates to methods for the treatment or prevention of trigeminal nerve-associated pain, in particular chronic, acute and procedural-related pain. The methods comprise administration of analgesic agents to the trigeminal nerve system which results in analgesia to the facial or head region.
Type:
Grant
Filed:
June 21, 2011
Date of Patent:
September 4, 2012
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Trigemina, Inc., HealthPartners Research Foundation
Inventors:
David C. Yeomans, William H. Frey, II, Daniel I. Jacobs, Martin S. Angst
Abstract: The present invention relates to methods for the treatment of headache and headache disorders. The methods comprise administration of an oxytocin peptide for the treatment of primary and secondary headaches or trigeminal neuralgia.
Type:
Grant
Filed:
October 7, 2011
Date of Patent:
August 28, 2012
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Trigemina, Inc., HealthPartners Research Foundation
Inventors:
David C. Yeomans, Martin S. Angst, William H. Frey, II, Daniel I. Jacobs
Abstract: The present invention relates to methods for the treatment of headache and headache disorders. The methods comprise administration of an oxytocin peptide for the treatment of primary and secondary headaches or trigeminal neuralgia.
Type:
Grant
Filed:
March 23, 2009
Date of Patent:
June 19, 2012
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Trigemina, Inc., HealthPartners Research Foundation
Inventors:
David C. Yeomans, Martin S. Angst, William H. Frey, II, Daniel I. Jacobs
Abstract: The present invention relates to methods for the treatment of headache and headache disorders. The methods comprise administration of an oxytocin peptide for the treatment of primary and secondary headaches or trigeminal neuralgia.
Type:
Grant
Filed:
September 15, 2008
Date of Patent:
June 12, 2012
Assignees:
The Board of Trustees of the Leland Stanford Junior University, Trigemina, Inc., HealthPartners Research Foundation
Inventors:
David C. Yeomans, Martin S. Angst, William H. Frey, II, Daniel I. Jacobs