Patents Assigned to TriLink Biotechnologies, LLC
  • TRINUCLEOTIDE CAP ANALOGS AND METHODS OF USE THEREOF
    Publication number: 20250108066
    Abstract: Described herein are novel trinucleotide cap analogs and methods of making and using the same. Also described herein is an RNA molecule comprising a 5?-cap, wherein the 5?-cap includes a trinucleotide cap analog as described herein. Methods of inducing a therapeutic effect in a 5 subject are also described herein, the methods including a step of administering to the subject an RNA molecule including the trinucleotide cap analog.
    Type: Application
    Filed: January 25, 2023
    Publication date: April 3, 2025
    Applicant: TriLink BioTechnologies, LLC
    Inventors: Chunping XU, Michael HOUSTON, Alexandre LEBEDEV, Jordana Michelle HENDERSON, Andrew UJITA, Inna KOUKHAREVA, Chanfeng ZHAO, Ilya Vladimirovich ILICHEV
  • Compositions and methods for synthesizing 5?-capped RNAs
    Patent number: 12258369
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: September 14, 2023
    Date of Patent: March 25, 2025
    Assignee: TriLink BioTechnologies, LLC
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Compositions and methods for synthesizing 5?-capped RNAs
    Patent number: 12103944
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: January 9, 2024
    Date of Patent: October 1, 2024
    Assignee: TriLink BioTechnologies, LLC
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS
    Publication number: 20240158433
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: January 9, 2024
    Publication date: May 16, 2024
    Applicant: TriLink BioTechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS
    Publication number: 20240140982
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: September 14, 2023
    Publication date: May 2, 2024
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Compositions and methods for synthesizing 5?-Capped RNAs
    Patent number: 11878991
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7 Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: January 23, 2024
    Assignee: TriLink BioTechnologies, LLC
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • Compositions and methods for synthesizing 5'-Capped RNAs
    Patent number: 11578095
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: February 14, 2023
    Assignee: TriLink Biotechnologies, LLC
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS
    Publication number: 20220289786
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: May 26, 2022
    Publication date: September 15, 2022
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • Compositions and methods for synthesizing 5?-capped RNAs
    Patent number: 11414453
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Grant
    Filed: August 2, 2021
    Date of Patent: August 16, 2022
    Assignee: TriLink Biotechnologies, LLC
    Inventors: Richard I. Hogrefe, Alexandre Lebedev, Anton P. McCaffrey, Dongwon Shin
  • COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS
    Publication number: 20210371452
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: August 2, 2021
    Publication date: December 2, 2021
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN
  • COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS
    Publication number: 20210261597
    Abstract: Provided herein are methods and compositions for synthesizing 5?Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7 Gppp[N2?Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
    Type: Application
    Filed: November 6, 2020
    Publication date: August 26, 2021
    Applicant: TriLink Biotechnologies, LLC
    Inventors: Richard I. HOGREFE, Alexandre LEBEDEV, Anton P. MCCAFFREY, Dongwon SHIN