Abstract: The object of the present invention is to provide a fundamental therapy to mitochondrial genetic diseases caused by mutation of the mitochondrial (mt)DNA, and a pharmaceutical composition used for the same. The object can be solved by a polyamide compound binding to a target double-stranded mtDNA comprising A/T pair consisting of first A of the following sense-stranded DNA and the corresponding T, A/T pair consisting of 8th A of the following sense-stranded DNA and the corresponding T, G/C pair consisting of 9th G of the following sense-stranded DNA and the corresponding C, G/C pair consisting of 14th G of the following sense-stranded DNA and the corresponding C, T/A pair consisting of 15th T of the following sense-stranded DNA and the corresponding A, or the like, in the double-stranded DNA consisting of the sense-stranded DNA having base sequence of 5?-ATGGCAGAGCCCGGTAATCGCATAA-3? (SEQ ID NO: 1) and the antisense-stranded DNA having base sequence of 5?-TTATGCGATTACCGGGCTCTGCCAT-3? (SEQ ID NO: 2).

Abstract: The claimed subject matter provides a system and/or method that facilitates creating a portion of an industrial process. An interface component can receive a first portion of data associated with a first programming language and a second portion of data associated with a second programming language, wherein the first programming language is independent and disparate of the second programming language. An editor component can create at least one of a portion of an industrial process or a portion of a mixed language object by enabling the combination of the first portion of data and the second portion of data independent of the respective programming languages.

Abstract: The claimed subject matter provides a system and/or method that facilitates creating a portion of an industrial process. An interface component can receive a first portion of data associated with a first programming language and a second portion of data associated with a second programming language, wherein the first programming language is independent and disparate of the second programming language. An editor component can create at least one of a portion of an industrial process or a portion of a mixed language object by enabling the combination of the first portion of data and the second portion of data independent of the respective programming languages.

Abstract: A tension control device for an anchor line rope of large diameter, which winds off or onto a winch drum at a marine vessel includes an arm with a first inner link arm with a first sheave arranged near the first link arm's outer end, a second, intermediate link arm arranged rotatable adjustable on the first arm and arranged with a second intermediate sheave near the second link arm's outer end, and a third, outer link arm arranged rotatable adjustable on the second, intermediate link arm and arranged with a third sheave near the third, outer link arm's outer end. The second, intermediate link arm's angle is regulated by use of a first actuator arranged between the first, inner link arm and the second link arm. The third, outer link arm's relative angle to the second, intermediate link arm is regulated by a second actuator. Each sheave includes a brake.

Abstract: An automation collaborative framework (ACF) is provided. The ACF includes an abstract automated model (AAM) that defines a generic data management scheme. The AAM is extended so as to define an extended data management scheme according to control solutions received from a user. A concrete automation model (CAM) then implements a concrete data management scheme, in which the concrete data management scheme is derived as a function of the generic data management scheme and the extended data management scheme.

Abstract: The claimed subject matter provides a system and/or method that facilitates creating executable code for an industrial environment. A language editor can enable a programming of a portion of data within a programming language. A compiler can compile the portion of data within the programming language. An assembler component can utilize an intermediate language to convert the portion of data into a portion of assembly object code, wherein the assembly object code is target independent. A linker can create a binary file from the portion of assembly object code, wherein the binary file is target independent. A loader can specifically tailor the binary file to a target resource by leveraging at least one PLC definition, wherein the loader creates a target executable code (TEC) program at runtime or at development time.

Abstract: This invention relates to line frequency synchronisation for use in diagnostics for alternating current electrical circuits. The invention provides a method of synchronising measurement system frequency with an alternating current line frequency comprising the steps of: adjusting the frequency of the measurement system frequency using a frequency locked loop until the measurement system frequency is within a predetermined range of said alternating current line frequency; and when the measurement system frequency is within a predetermined range of said alternating current line frequency adjusting the phase and the frequency of the measurement system frequency using a phase and frequency locked loop.

Abstract: This invention relates to fault detection in electrical circuits. The invention provides a switch for a fault tolerant digital output module comprising: an output transistor pair for enabling and disabling an alternating output current; and a current limiter for clamping the output current to a predetermined maximum value.

Abstract: A control system development platform is provided. The platform includes a shell component adapted to support development of a control systems application. An abstract model is associated with the shell component to facilitate development of the control systems applications.

Abstract: An automation collaborative framework (ACF) is provided. The ACF includes an abstract automated model (AAM) that defines a generic data management scheme. The AAM is extended so as to define an extended data management scheme according to control solutions received from a user. A concrete automation model (CAM) then implements a concrete data management scheme, in which the concrete data management scheme is derived as a function of the generic data management scheme and the extended data management scheme.

Abstract: A control system development platform is provided. The platform includes a shell component adapted to support development of a control systems application. An abstract model is associated with the shell component to facilitate development of the control systems applications.

Abstract: A control system development platform is provided. The platform includes a shell component adapted to support development of a control systems application. An abstract model is associated with the shell component to facilitate development of the control systems applications.

Abstract: A control system development platform is provided. The platform includes a shell component adapted to support development of a control systems application. An abstract model is associated with the shell component to facilitate development of the control systems applications.

Abstract: The claimed subject matter provides a system and/or method that facilitates creating a portion of an industrial process. An interface component can receive a first portion of data associated with a first programming language and a second portion of data associated with a second programming language, wherein the first programming language is independent and disparate of the second programming language. An editor component can create at least one of a portion of an industrial process or a portion of a mixed language object by enabling the combination of the first portion of data and the second portion of data independent of the respective programming languages.

Abstract: The claimed subject matter provides a system and/or method that facilitates creating executable code for an industrial environment. A language editor can enable a programming of a portion of data within a programming language. A compiler can compile the portion of data within the programming language. An assembler component can utilize an intermediate language to convert the portion of data into a portion of assembly object code, wherein the assembly object code is target independent. A linker can create a binary file from the portion of assembly object code, wherein the binary file is target independent. A loader can specifically tailor the binary file to a target resource by leveraging at least one PLC definition, wherein the loader creates a target executable code (TEC) program at runtime or at development time.

Abstract: This invention relates to overload protection for a circuit driving a direct current (DC) load.

Abstract: A lighting subassembly includes at least one light emitting device, a solid, light transmitting material, and a mating arrangement. The solid, light-transmitting material at least partially surrounds the at least one light emitting device. The mating arrangement communicates with the solid, light transmitting material and is configured to be attachable to a corresponding base assembly. In some examples, the lighting subassembly further includes a frame and the frame is integral with the solid, light-transmitting material.

Abstract: This invention relates to fault detection in electrical circuits. The invention provides a method and apparatus for testing an input circuit by generating a periodic test signal having a predetermined phase and a predetermined amplitude; summing the test signal and an input signal to provide a summed signal; processing the summed signal to provide an output signal; generating an extracted test signal from the output signal; comparing the extracted test signal with a reference signal representing said periodic test signal; generating an error signal in dependence upon the result of said comparing step. The invention also provides a method and apparatus for testing a plurality of adjacent input circuits.

Abstract: This invention relates to a speed monitor apparatus for monitoring speed and acceleration of rotating turbine equipment (turbomachinery) and for operating an overspeed trip to shut down the equipment in the event that the speed or acceleration exceed predetermined thresholds. The invention provides a speed monitor module wherein the speed monitor module may be may be plugged in to the same chassis as a module which is controlling the speed of the turbine, and wherein the turbine speed monitor is arranged to receive configuration parameters relating to the overspeed threshold and the overacceleration threshold only when the turbine is operating at a speed lower than a predetermined threshold.