Patents Assigned to Triumvira Immunologics USA, Inc.
  • T cell-antigen coupler with various construct optimizations
    Patent number: 11878035
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Grant
    Filed: March 22, 2023
    Date of Patent: January 23, 2024
    Assignees: Triumvira Immunologics USA, Inc., McMaster University
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi
  • T cell-antigen coupler with various construct optimizations
    Patent number: 11110123
    Abstract: A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: September 7, 2021
    Assignees: Triumvira Immunologics USA, Inc., McMaster University
    Inventors: Jonathan Lorne Bramson, Christopher W. Helsen, Joanne Alicia Hammill, Kenneth Anthony Mwawasi