Patents Assigned to Trojan Technologies, Ltd.
  • Conjugate comprising P21 protein for the treatment of cancer
    Patent number: 9145446
    Abstract: The P21 protein is used as a medicament in the treatment of cancer. A conjugate comprises a first region comprising the P21 protein, or a homologue or functional fragment thereof; and a second region comprising a translocation factor.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: September 29, 2015
    Assignee: Trojan Technologies, Ltd.
    Inventors: Agamemnon Epenetos, Christina Kousparou
  • Methods of determining cancer cell responsiveness to a notch inhibitory agent
    Patent number: 8748112
    Abstract: The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also provided are methods of modulating the expression and/or activity of proteins in the Notch signaling pathway for use in diagnoses and treatment of cancer in a subject.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: June 10, 2014
    Assignee: Trojan Technologies, Ltd.
    Inventor: Spyros Stylianou
  • Antennapedia-dominant negative mastermind-like construct
    Patent number: 8119366
    Abstract: The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also provided are methods of modulating the expression and/or activity of proteins in the Notch signaling pathway for use in diagnoses and treatment of cancer in a subject.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: February 21, 2012
    Assignee: Trojan Technologies, Ltd.
    Inventor: Spyros Stylianou
  • THERAPEUTIC ANTENNAPEDIA-ANTIBODY MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20100266592
    Abstract: The present invention is based on the seminal discovery that an antibody or fragment thereof combined with Antennapedia or a fragment thereof, is an effective therapeutic agent. The invention describes the construction of antibody or antibody fragment fused or chemically conjugated with Antennapedia at its carboxyl or its amino terminus (a “cargo-carrier” construct).
    Type: Application
    Filed: April 14, 2010
    Publication date: October 21, 2010
    Applicant: Trojan Technologies, Ltd.
    Inventors: Agamemnon A. Epenetos, Christina Kousparou
  • DELIVERY OF NUCLEIC ACIDS USING CELL-PENETRATING PEPTIDES
    Publication number: 20100190691
    Abstract: The present invention is based on the innovative concept of conjugating a cell-penetrating peptide (CPP), including a protein transduction domain, to a nucleic acid molecule to provide a nucleic acid-protein conjugate exhibiting enhanced cellular uptake. Accordingly, the invention provides a method of producing a cell permeable nucleic acid molecule conjugate nucleic acid including a nucleic acid conjugated with a homeodomain of an antennapedia homeotic transcription factor protein (Antp), or functional fragment thereof. The invention further provides compositions and methods treating a subject using the conjugates produced by the method described herein.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 29, 2010
    Applicant: Trojan Technologies, Ltd
    Inventors: Agamemnon A. Epenetos, Christina Kousparou