Patents Assigned to Trojan Technologies, Ltd.
  • Conjugate comprising P21 protein for the treatment of cancer
    Patent number: 9145446
    Abstract: The P21 protein is used as a medicament in the treatment of cancer. A conjugate comprises a first region comprising the P21 protein, or a homologue or functional fragment thereof; and a second region comprising a translocation factor.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: September 29, 2015
    Assignee: Trojan Technologies, Ltd.
    Inventors: Agamemnon Epenetos, Christina Kousparou
  • Methods of determining cancer cell responsiveness to a notch inhibitory agent
    Patent number: 8748112
    Abstract: The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also provided are methods of modulating the expression and/or activity of proteins in the Notch signaling pathway for use in diagnoses and treatment of cancer in a subject.
    Type: Grant
    Filed: February 17, 2012
    Date of Patent: June 10, 2014
    Assignee: Trojan Technologies, Ltd.
    Inventor: Spyros Stylianou
  • Antennapedia-dominant negative mastermind-like construct
    Patent number: 8119366
    Abstract: The present invention is based on the discovery that the Notch signaling pathway is associated with cancer. Accordingly, the invention provides methods and compositions for treating cancer. Also provided are methods of modulating the expression and/or activity of proteins in the Notch signaling pathway for use in diagnoses and treatment of cancer in a subject.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: February 21, 2012
    Assignee: Trojan Technologies, Ltd.
    Inventor: Spyros Stylianou
  • THERAPEUTIC ANTENNAPEDIA-ANTIBODY MOLECULES AND METHODS OF USE THEREOF
    Publication number: 20100266592
    Abstract: The present invention is based on the seminal discovery that an antibody or fragment thereof combined with Antennapedia or a fragment thereof, is an effective therapeutic agent. The invention describes the construction of antibody or antibody fragment fused or chemically conjugated with Antennapedia at its carboxyl or its amino terminus (a “cargo-carrier” construct).
    Type: Application
    Filed: April 14, 2010
    Publication date: October 21, 2010
    Applicant: Trojan Technologies, Ltd.
    Inventors: Agamemnon A. Epenetos, Christina Kousparou