Patents Assigned to Trophos
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Patent number: 8691854Abstract: The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated. Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products. The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.Type: GrantFiled: June 29, 2006Date of Patent: April 8, 2014Assignee: TrophosInventors: Corinne Chaimbault, Cyrille Drouot, Laure Jamot, Rebecca Pruss, Céline Simon
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Patent number: 8575138Abstract: A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ?N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.Type: GrantFiled: August 22, 2012Date of Patent: November 5, 2013Assignee: TrophosInventors: Thierry Bordet, Cyrille Drouot, Bruno Buisson
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Patent number: 8481515Abstract: The object of the invention is the use as a drug of a compound fitting formula I wherein X represents an oxygen atom or a ?N—OH group and R represents a group selected from or one of its esters and/or of its addition salts with pharmaceutically acceptable acids, particularly as a cytoprotective drug, preferentially a cardioprotective and/or neuroprotective drug, the compounds of formula I wherein R is R2, R3, R4, R5 or R6 as novel compounds as well as their preparation method and use.Type: GrantFiled: December 15, 2006Date of Patent: July 9, 2013Assignee: TrophosInventors: Cyrille Drouot, Delphine Maux
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Patent number: 8354395Abstract: A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ?N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.Type: GrantFiled: August 22, 2012Date of Patent: January 15, 2013Assignee: TrophosInventors: Thierry Bordet, Cyrille Drouot, Bruno Buisson
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Patent number: 8338488Abstract: The invention relates to the use of at least one oxime derivative of 3,5-seco-4-norcholestane as antioxidants in the cosmetics and food fields, and as antioxidant preservatives that can be used, in particular, in cosmetic, food and pharmaceutical products.Type: GrantFiled: July 24, 2008Date of Patent: December 25, 2012Assignee: TrophosInventors: Rebecca Pruss, Cyrille Drouot
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Patent number: 8283341Abstract: A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ?N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.Type: GrantFiled: May 7, 2010Date of Patent: October 9, 2012Assignee: TrophosInventors: Thierry Bordet, Cyrille Drouot, Bruno Buisson
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Patent number: 7985774Abstract: The present invention relates to the use of 3,5-seco-4-nor-cholestane derivatives for obtaining a cytoprotective drug, with the exception of a neuroprotective drug, notably a cardioprotective or hepatoprotective drug.Type: GrantFiled: February 23, 2007Date of Patent: July 26, 2011Assignee: TrophosInventors: Rebecca Pruss, Bruno Buisson, Thierry Bordet
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Publication number: 20090203747Abstract: The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated. Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products. The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.Type: ApplicationFiled: June 29, 2006Publication date: August 13, 2009Applicant: Trophos Parc Scientifique LuminyInventors: Corinne Chaimbault, Cyrille Drouot, Laure Jamot, Rebecca Pruss, Celine Simon
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Patent number: 7372626Abstract: The invention concerns methods and devices for observing or analysing samples on a support. More particularly, it concerns a device for sequential observation of several samples arranged on a common plate (19) comprising an objective (15) for observing a stage (17) for positioning the plate (19) adapted to ensure a relative displacement between the plate (19) and the observation axis in a plane perpendicular to the observation axis, while leaving free the vertical displacement along the observation axis, means (21) for illuminating the sample and means (23, 25) for acquiring an image at the objective (15) output.Type: GrantFiled: May 10, 2001Date of Patent: May 13, 2008Assignee: TrophosInventors: Pascal Villa, Michel Delaage, Toni Williamson
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Patent number: 6949354Abstract: The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.Type: GrantFiled: December 7, 2000Date of Patent: September 27, 2005Assignee: TrophosInventors: Pascal Villa, Michel Delaage, Toni Williamson, Christopher Henderson