Patents Assigned to Trophos
  • Patent number: 8691854
    Abstract: The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated. Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products. The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: April 8, 2014
    Assignee: Trophos
    Inventors: Corinne Chaimbault, Cyrille Drouot, Laure Jamot, Rebecca Pruss, Céline Simon
  • Patent number: 8575138
    Abstract: A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ?N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: November 5, 2013
    Assignee: Trophos
    Inventors: Thierry Bordet, Cyrille Drouot, Bruno Buisson
  • Patent number: 8481515
    Abstract: The object of the invention is the use as a drug of a compound fitting formula I wherein X represents an oxygen atom or a ?N—OH group and R represents a group selected from or one of its esters and/or of its addition salts with pharmaceutically acceptable acids, particularly as a cytoprotective drug, preferentially a cardioprotective and/or neuroprotective drug, the compounds of formula I wherein R is R2, R3, R4, R5 or R6 as novel compounds as well as their preparation method and use.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: July 9, 2013
    Assignee: Trophos
    Inventors: Cyrille Drouot, Delphine Maux
  • Patent number: 8354395
    Abstract: A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ?N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: August 22, 2012
    Date of Patent: January 15, 2013
    Assignee: Trophos
    Inventors: Thierry Bordet, Cyrille Drouot, Bruno Buisson
  • Patent number: 8338488
    Abstract: The invention relates to the use of at least one oxime derivative of 3,5-seco-4-norcholestane as antioxidants in the cosmetics and food fields, and as antioxidant preservatives that can be used, in particular, in cosmetic, food and pharmaceutical products.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: December 25, 2012
    Assignee: Trophos
    Inventors: Rebecca Pruss, Cyrille Drouot
  • Patent number: 8283341
    Abstract: A method for providing neuroprotection to a patient in need of neuroprotection, comprising administering a neuroprotective-effective amount of a compound of formula I in which X is an oxygen atom or an ?N—OH group, R is selected from the group consisting of A is a hydrogen atom or together with B a carbon-carbon bond, B is a hydrogen atom, a hydroxy group or together with A a carbon-carbon bond, C is a hydrogen atom or together with D a carbon-carbon bond, D is a hydrogen atom or together with C a carbon-carbon bond, E is a hydrogen atom or together with F a carbon-carbon bond, F is a hydrogen atom or together with E a carbon-carbon bond, or an addition salt with a pharmaceutically acceptable acid.
    Type: Grant
    Filed: May 7, 2010
    Date of Patent: October 9, 2012
    Assignee: Trophos
    Inventors: Thierry Bordet, Cyrille Drouot, Bruno Buisson
  • Patent number: 7985774
    Abstract: The present invention relates to the use of 3,5-seco-4-nor-cholestane derivatives for obtaining a cytoprotective drug, with the exception of a neuroprotective drug, notably a cardioprotective or hepatoprotective drug.
    Type: Grant
    Filed: February 23, 2007
    Date of Patent: July 26, 2011
    Assignee: Trophos
    Inventors: Rebecca Pruss, Bruno Buisson, Thierry Bordet
  • Publication number: 20090203747
    Abstract: The present invention relates to the field of pharmacy, especially the treatment of neurodegenerative diseases. The invention specifically relates to a family of chemical compounds for which a neuroprotective activity has been demonstrated. Given that certain members of said family are novel compounds which have never been described, the invention relates to said novel products, the synthesis method thereof and certain novel intermediate synthesis products. The present invention further relates to compositions comprising the compounds of said family, and the use of said compounds as medicaments, especially for the preparation of a medicament for the treatment of neurodegenerative diseases.
    Type: Application
    Filed: June 29, 2006
    Publication date: August 13, 2009
    Applicant: Trophos Parc Scientifique Luminy
    Inventors: Corinne Chaimbault, Cyrille Drouot, Laure Jamot, Rebecca Pruss, Celine Simon
  • Patent number: 7372626
    Abstract: The invention concerns methods and devices for observing or analysing samples on a support. More particularly, it concerns a device for sequential observation of several samples arranged on a common plate (19) comprising an objective (15) for observing a stage (17) for positioning the plate (19) adapted to ensure a relative displacement between the plate (19) and the observation axis in a plane perpendicular to the observation axis, while leaving free the vertical displacement along the observation axis, means (21) for illuminating the sample and means (23, 25) for acquiring an image at the objective (15) output.
    Type: Grant
    Filed: May 10, 2001
    Date of Patent: May 13, 2008
    Assignee: Trophos
    Inventors: Pascal Villa, Michel Delaage, Toni Williamson
  • Patent number: 6949354
    Abstract: The present invention relates to compositions and methods for screening and/or identifying compounds exhibiting biological activity on neurons. The invention also relates to the isolation and culture of neurons, methods of inducing pathological conditions to said isolated neurons, as well as kits for implementing said methods. The invention can be used in experimental research, drug discovery, drug development, and the like. More particularly, the invention can be used to identify and/or characterize and/or improve compounds which are active on neurons and can be used for treating disorders of the nervous system.
    Type: Grant
    Filed: December 7, 2000
    Date of Patent: September 27, 2005
    Assignee: Trophos
    Inventors: Pascal Villa, Michel Delaage, Toni Williamson, Christopher Henderson