Abstract: The present specification provides RXR agonist compounds, compositions comprising such RXR agonists, and methods using such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection as well as use of such RXR agonists to manufacture a medicament and use of such compounds and compositions to treat an autoimmune disorder, inflammation associated with an autoimmune disorder and/or a transplant rejection.

Abstract: A bilateral humeral guide for intraosseous infusion includes a three-dimensional mirror symmetric shell configured to fit on either shoulder of a patient, the shell being symmetric about a plane bisecting an alignment hole configured to aid positioning of the shell on the shoulder by aligning the alignment hole on acromion of the shoulder, and two insertion-site indication holes symmetrically positioned on two opposite sides of the plane, the insertion-site indication holes including a left and a right hole each configured to indicate insertion sites for intraosseous infusion through the shell to a target region of a left or right humerus of the patient when the shell is positioned on the shoulder corresponding to the respective humerus.

Abstract: Embodiments of the present disclosure pertain to methods of capturing one or more ions from an environment by associating the environment with a composition that includes a metal-organic framework. The association results in the capture of the one or more ions by the metal-organic framework. The metal-organic frameworks may include a plurality of metals and a plurality of triphenylene-based ligands that interconnect the plurality of the metals. The methods of the present disclosure may also include a step of detecting one or more captured ions. Additional embodiments of the present disclosure pertain to the compositions for capturing one or more ions from an environment.

Abstract: The disclosure provides high strength high-entropy alloys with compositions (in atomic %) of FeaNibMncAldCreCf where 37-43 atomic %, b is 8-14 atomic %, c is 27-33 atomic %, d is 4-10 atomic %, e is 10-14 atomic %, and f is 0-2 atomic %.

Abstract: The present disclosure relates to compositions and therapeutic methods for activating an immune response in a patient in need thereof. In a preferred embodiment, the subject methods and compositions are able to antagonize the activity of VISTA, a naturally occurring “checkpoint” protein which contributes to immune tolerance, optionally in combination with an antagonist of a second checkpoint pathway such as PD-1. For example, such methods and compositions may be suitable for preventing and treating colon cancer or another cancer. An exemplary VISTA antagonist, specifically, an anti-VISTA antibody, is demonstrated herein to activate an immune response against cancer cells in vitro and in vivo, thereby conferring protective anti-tumor immunity which decreased tumor burden. Additionally, an additive benefit was observed when a VISTA antagonist was used in combination with a second checkpoint protein antagonist, specifically, an antibody against PD-1 ligand (PD-L1).

Abstract: Aspects of the disclosure provide a sensing apparatus including a sensing device, a memory, and processing circuitry. The sensing device includes resonators having respective resonant frequencies. The resonators include an array of inductive coils positioned on a surface of the apparatus. The sensing device can output a signal indicating changes of the resonant frequencies caused by presence of an object proximate to the surface. The memory stores reference signals corresponding to reference objects. Each reference signal indicates changes of the resonant frequencies caused by the respective reference object proximate to the surface. The processing circuitry can receive, from the sensing device, a particular signal indicating changes of the resonant frequencies caused by presence of a particular object proximate to the surface. The processing circuitry compares the particular signal with the stored reference signals of the reference objects to determine an identity of the particular object.

Abstract: Some embodiments of the present disclosure provide a semiconductor-based photon-counting sensor comprising a metal-insulator-semiconductor internal photoemission (e.g., thermionic-emission) detector formed on and/or in a first surface of a semiconductor substrate, and at least one jot formed on and/or in a second side of a semiconductor substrate. The at least one MIS photoemission detector and the at least one jot are configured such that a photocarrier generated in response to a photon incident on the MIS thermionic-emission detector is readout by the at least one jot.

Abstract: The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.

Abstract: An imaging system, such as a surgical microscope, laparoscope, or endoscope or integrated with these devices, includes an illuminator providing patterned white light and/or fluorescent stimulus light. The system receives and images light hyperspectrally, in embodiments using a hyperspectral imaging array, and/or using narrowband tunable filters for passing filtered received light to an imager. Embodiments may construct a 3-D surface model from stereo images, and will estimate optical properties of the target using images taken in patterned light or using other approximations obtained from white light exposures. Hyperspectral images taken under stimulus light are displayed as fluorescent images, and corrected for optical properties of tissue to provide quantitative maps of fluorophore concentration. Spectral information from hyperspectral images is processed to provide depth of fluorophore below the tissue surface. Quantitative images of fluorescence at depth are also prepared.

Abstract: Disclosed is a system for evaluating brain trauma via regional changes in tissue impedance. The present disclosure describes a system for non-invasive intracranial monitoring, comprising two or more affecting electrodes arranged between a conductive location of a cranium of a patient and a location on a scalp of the patient, two or more effected electrodes arranged between the conductive location of the cranium of the patient and the location on the scalp of the patient, and processing circuitry configured to apply an electrical stimulus between the two or more affecting electrodes, measure an electrical stimulus differential between the two or more effected electrodes, calculate, for the two or more effected electrodes, a value of an impedance metric, and identify, based on the calculated value of the impedance metric, a health condition of the patient.

Abstract: Embodiments of the present disclosure pertain to transmission dielectric probes with at least one channel that extends across the probe. The channel includes a first opening on a first side of the transmission dielectric probe, and a second opening on a second side of the transmission dielectric probe. The first opening and the second opening are on opposite ends of the transmission dielectric probe, and the second opening is associated with an outer surface of the transmission dielectric probe. Additionally, the first opening and the second opening have different diameters, different geometries, or combinations thereof. Further embodiments pertain to methods of operating the transmission dielectric probes by placing the outer surface of the transmission dielectric probe on a surface of an object, transmitting a signal from a first channel through the surface and into the object, and receiving the transmitted signal back through a second channel.

Abstract: Disclosed herein are image apparatuses comprising a frontside surface, a backside surface, a storage region (e.g., a storage node or a floating diffusion node), the storage region being situated closer to the frontside surface than to the backside surface, a storage well situated between the backside surface and the storage region, and a doping region situated between the storage region and the storage well. An impurity type of the doping region is opposite an impurity type of the storage well. A lateral area of the storage well is greater than or equal to a lateral area of the storage region, and no portion of a lateral perimeter of the storage region extends outside of a lateral perimeter of the storage well.

Abstract: Embodiments of the present disclosure pertain to ion-selective electrodes that include a metal-organic framework and an electrode surface. The metal-organic framework is associated with the electrode surface in a manner that forms an interface between the metal-organic framework and the electrode surface. Additional embodiments pertain to methods of detecting an ion in a sample by associating the sample with the ion-selective electrodes of the present disclosure. The metal-organic frameworks of the ion-selective electrodes mediate ion-to-electron transduction through the interface between the metal-organic and the electrode surface. Thereafter, the presence or absence of the ion in the sample is detected by detecting a change in potential of the ion-selective electrode and correlating the change in the potential to the presence or absence of the ion.

Abstract: Methods for producing enantiodefined polycyclic compounds, particularly tetracyclic compounds, are provided. More particularly, synthetic methods for producing biologically active enantiodefined steroidal compositions of both natural (“nat-”) and unnatural (“ent-”) absolute stereochemistry are provided. An exemplary method for manufacturing a tetracyclic compound comprises a step of forming a hydrindane intermediate through coupling of a suitably functionalized enyne with a suitably functionalized alkyne and subsequently performing an intramolecular ring-closing reaction to form the tetracyclic compound. Steroidal compounds obtained by this method and methods of using such steroidal compounds in human and/or animal therapeutics and medicines are also provided.

Abstract: Disclosed are infrared (IR) light detectors. The detectors operate by generating hot electrons in a metallic absorber layer on photon absorption, the electrons being transported through an energy barrier of an insulating layer to a metal or semiconductor conductive layer. The energy barrier is set to bar response to wavelengths longer than a maximum wavelength. Particular embodiments also have a pattern of metallic shapes above the metallic absorber layer that act to increase photon absorption while reflecting photons of short wavelengths; these particular embodiments have a band-pass response.

Abstract: In an embodiment, the present disclosure pertains to methods of inhibiting bacterial growth. Generally, the methods include exposing bacteria to an anti-bacterial compound as disclosed herein. In some embodiments, the exposing occurs in vivo in a subject in order to treat or prevent a bacterial infection. In additional embodiments, the present disclosure pertains to anti-bacterial compounds that are suitable for inhibiting bacterial growth.

Abstract: In one aspect, described is a magnetic-core inductor design approach that leverages NiZn ferrites with low loss at RF, distributed gaps and field balancing to achieve improved performance eat tens of MHz and at hundreds of watts and above. Also described is an inductor design which achieves “self-shielding” in which the magnetic field generated by the element is wholly contained within the physical volume of the structure rather than extending into space as a conventional air-core inductor would. This approach enables significant reductions of system enclosure volume and improvements in overall system efficiency.

Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed. In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

Abstract: This invention provides a hand-held stereovision (HHS) system that is an efficient, accurate, and radiation-free imaging device to acquire intraoperative profiles of the exposed spine in prone position. The reconstructed intraoperative stereovision surfaces (iSV) are registered with preoperative CT (pCT; supine position) in a nonrigid fashion to generate updated CT images (uCT) and correct for vertebral posture and alignment changes. Updated CT images are uploaded to a commercial navigation system for surgical navigation.

Abstract: Systems and methods for monitoring a range of motion of a joint are described. For example, in one embodiment, a first set of sensors may sense accelerations of a first body portion located on a first side of the joint and a second set of sensors may sense accelerations of the second body portion located on a second opposing side of the joint. The acceleration data may then be used to compute the relative motion of the first and second body portions to determine movement of the joint. This joint movement may then be used to determine one or more range of motion movement metrics which are output for viewing by a subject or medical practitioner.