Abstract: Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (ORF) for a protein under the control of regulatory sequences which direct expression of the product in cell, which ORF has been modified to preferentially increase expression levels in a selected tissue, wherein the modified ORF is characterized by a triplet frequency of any one of Tables 3-12, 16 or 17.

Abstract: An embodiment may involve determining that a first logical partition of a scratchpad memory coupled to a processor core is empty and a first application is scheduled to execute; instructing a direct memory access (DMA) engine to load the first application into the first logical partition and then instructing the processor core to execute the first application from the first logical partition; while the first application is being executed from the first logical partition, determining that a second logical partition of the scratchpad memory is empty and a second application is scheduled to execute; instructing the DMA engine to load the second application into the second logical partition; determining that execution of the first application has completed; and instructing the DMA engine to unload the first application from the first logical partition and instructing the processor core to execute the second application from the second logical partition.

Abstract: The disclosure relates to a plant growth apparatus and related system to grow and maintain plants under controlled biotic conditions, for example to grow axenic (microbe-free) plants, gnotobiotic (defined microbiota) plants, and holoxenic (complex, or undefined microbiota) plants. This system allows aseptic bottom irrigation with water, soluble nutrients, chemicals, and/or microbiota. Plants can be inverted for dipping and/or vacuum infiltration. The system also allows for passive (gravity) drainage, thereby allowing for gas exchange and preventing root anoxia. A variety of plant growth substrates can be used within the plant growth apparatus as a plant growth medium. The plant growth apparatus, containing the growth substrate medium, can be completely flushed via the drainage port to remove potential toxic byproducts of the sterilization processes. The entire system is suitably constructed using autoclavable material.

Abstract: The present invention relates to a method for the treatment of cancer or an autoimmune disorder, comprising the administration of a serine hydroxymethyltransferase (SHMT) inhibitor, and in particular the administration of pyrazolopyran compounds of Formula (VI) as presently described, wherein the compounds are capable of inhibiting a mammalian SHMT, such as human SHMT1 and/or SHMT2. The treatment method further comprises the optional administration of an additional agent as a rescue therapy to reduce toxicity, wherein said agent may be chosen from formate, a formate salt, folinic acid, formate ester, or leucovorin.

Abstract: The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).

Abstract: A method of increasing the probability and rate of seed germination, increasing vegetative biomass, and increasing water uptake in seeds, in which a seed is introduced to an effective concentration of carbon nanomaterial. The effective concentration of carbon nanomaterial is 10-200 ?g/mL.

Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.

Abstract: This invention provides nucleoside polyphosphate analogs each of which comprises a tag comprising a plurality of Raman-scattering moieties; compounds comprising said nucleoside polyphosphate analogs; and methods for determining the sequence of a single-stranded DNA or RNA using said nucleoside polyphosphate analogs. This invention also provides methods for detecting the interaction of a plurality of predetermined compounds, at least one of which having attached thereto a tag comprising a plurality of Raman-scattering moieties.

Abstract: A system, and methods, for transmitting quantum states between a first node and a second node, or among more than two nodes. Each node is characterized by an instantaneous spatial position, and the instantaneous spatial position of the second node is repositionable within a frame of reference associated with the first node. A hovering drone is adapted either for running a quantum key transmission protocol in secure communication with the first node, and/or for running a quantum key reception protocol in secure communication with the second node. Either drone may serve as a relay of optical data between a base station and another drone. Secure communication among more than two nodes may be reconfigured.

Abstract: Bonded surfaces are formed by adhering first nanorods and second nanorods to respective first and second surfaces. The first shell is formed on the first nanorods and the second shell is formed on the second nanorods, wherein at least one of the first nanorods and second nanorods, and the first shell and the second shell are formed of distinct metals. The surfaces are then exposed to at least one condition that causes the distinct metals to form an alloy, such as eutectic alloy having a melting point below the temperature at which the alloy is formed, thereby bonding the surfaces upon which solidification of the alloy.

Abstract: A user authentication system for an electronic device for use with a plurality of wireless wearable medical sensors (WMSs) and a wireless base station that receives a biomedical data stream (biostream) from each WMS. The system includes a BioAura engine located on a server, the server has a wireless transmitter/receiver with receive buffers that store the plurality of biostreams, the BioAura engine has a look up stage and a classifier, the classifier generates an authentication output based on the plurality of biostreams, the authentication output authenticates the user's access to the electronic device. The wireless base station has a transmitter/receiver having receive buffers that store the biomedical data from each WMS, the wireless base station has a communication engine that retrieves the biostream from each WMS and transmits the plurality of biostreams to the server.

Abstract: The present invention includes methods for transferring a multigenic phenotype to a cell by transfecting, preferably by phototransfection, and locally transfecting a cell or a cellular process with a laser while the cell is bathed in a fluid medium comprising two or more nucleic acids, thereby introducing the nucleic acid into the interior of the cell. Expression of the nucleic acids results in a multigenic phenotype in the transfected cell.

Abstract: A construct that supports cell attachment and alignment including a substrate that is incompatible with photolithography conditions, containing a physical pattern in at least part of one surface, the physical pattern optionally bearing a coating of a metal alkoxide, oxide or mixed oxide-alkoxide thereon and a Self-Assembled Monolayer of Phosphonate (SAMP) covalently attached thereto, which phosphonate contains functionality adapted for cell binding. The construct optionally also contains cells attached thereto. Also disclosed are methods of preparing such a construct.

Abstract: Some embodiments provide an image sensor that includes (i) quanta image sensor having an array of jots and configured for spatial and temporal oversampling, and (ii) a polarization filter array monolithically integrated with the quanta image sensor, so as to provide for a polarization image sensor. The image sensor may also include a color filter array.

Abstract: The present invention provides a shear gripper device using fibrillar, gecko-inspired adhesives that have the characteristics of being non-tacky in its default state and requiring no normal force to grip a surface. The adhesion is turned “on” by the applied shear load, and “off as the shear load is removed. The shear adhesive gripper is able to grasp large, deformable or delicate objects using a delicate touch.

Abstract: A storage container to receive and store a biopsy sample of an organism, held by a biopsy sample collector, the storage container comprising a container body defining a containment region with an open end, and a container cap removably located at the open end to seal the containment region, the cap including a passage that is closed by a closure that is able to be ruptured to allow a biopsy sample retaining biopsy sample collector to thereat enter the containment region so that the sample can be stored in the containment region and the sample collector can seal the passage.

Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-28 or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.

Abstract: This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3?-position of the deoxyribose.

Abstract: The presently disclosed technology relates to a nano-additives to improve the performance of lubricants, oils, and greases. More specifically, the presently disclosed technology relates to applying capped metal oxide nanoparticles, such as capped zirconia nanoparticles, in the lubricants to produce a tribofilms on the lubricating surfaces to provide wear protection to the said surfaces. Also, the interaction of the capped zirconia nanoparticles with other commonly used additives in lubricants may further optimize the performance of the resulting tribofilms.

Abstract: The subject matter disclosed herein relates to methods for diagnosing a neurological disorder in a subject. In certain aspects, the methods described herein involve determining one or more critical areas in the brain from PET data where two groups differ and measuring PET signal within determined critical areas in a new subject in order to assign risk or diagnosis.