Abstract: The disclosure relates generally to improved methods for the reduction of carbon dioxide. The disclosure relates more specifically to catalytic methods for electrochemical reduction of carbon dioxide that can be operated at commercially viable voltages and at low overpotentials. The disclosure uses a transition metal dichalcogenide and helper catalyst in contact within the cell.

Abstract: This disclosure presents 4-MUG derivatives (e.g., 4-MUG ester prodrugs) that reduce or prevent HA synthesis. In some embodiments, the 4-MUG derivatives of the present disclosure can be used to suppress HA synthesis and curtail inflammation.

Abstract: A robotic surgical station is described. The robotic surgical station has a base configured to be fixed to the ground, a ring-shaped structure to which a patient bed and a plurality of robot arms are restrained at respective first and second mounts and a remote control unit that may be used by a surgeon to carry out a surgical intervention on a patient.

Abstract: A method for providing at least one measurement by a magnetic resonance imaging (MRI) system of a tissue property or underlying tissue property in a region sufficiently close to a metal object, so that the metal object induces artifacts is provided. At least one magnetic resonance imaging signal from the region is acquired through the MRI system. The acquired at least one MRI signal is processed to correct for artifacts induced by the metal object. At least one tissue property or underlying tissue property measurement is extracted from the processed at least one MRI signal.

Abstract: An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of teeth. When operating in vivo, radiation induced spectra are obtained from intact teeth placed within a magnetic field and with a resonator having a loop and two capacitors formed in metal layers on a printed circuit substrate and located near teeth. The resonator is magnetically coupled to an RF measuring system. The spectra are used to determine radiation dose of a subject. The characteristics of the method and the apparatus make it feasible to utilize the system to measure radiation dose using previously untrained operators working in the field under emergency conditions.

Abstract: The present disclosure provides DNA-based storage system demonstrated through experimental and theoretical verification that such a platform can easily be implemented in practice using portable, nanopore-based sequencers. The gist of the approach is to design an integrated pipeline that encodes data to avoid synthesis and sequencing errors, enables random access through addressing, and leverages efficient portable nanopore sequencing via new anchored iterative alignment and insertion/deletion error-correcting codes. The embodiments herein represent the only known random access DNA-based data storage system that uses error-prone portable, nanopore-based sequencers and produces low-error readouts with the highest reported information rate and density.

Abstract: The present invention provides a humanized antibody or antibody fragment comprising (a) a humanized light chain comprising 1) Complementarity Determining Region (CDR)-L1, the sequence of which is identical to the sequence of SEQ ID NO: 3; 2) CDR-L2, the sequence of which is identical to the sequence of SEQ ID NO: 4; and 3) CDR-L3, the sequence of which is identical to the sequence of SEQ ID NO: 5, and (b) a humanized heavy chain comprising 1) CDR-H1, the sequence of which is identical to the sequence of SEQ ID NO: 6; 2) CDR-H2, the sequence of which is identical to the sequence of SEQ ID NO: 7; and 3) CDR-H3, the sequence of which is identical to the sequence of SEQ ID NO: 8, as well as methods for treating, diagnosing, and monitoring the progression of HIT. The present invention also provides methods for assessing the antigenicity and ability to cause HIT of anionic anticoagulants.

Abstract: The presently disclosed subject matter relates to iron oxide nanoparticle compositions and formulations thereof for: (1) the treatment and elimination of biofilms; (2) the prevention of biofilm formation; (3) biofilm extracellular matrix degradation; (4) the inhibition of bacterial viability and growth within the biofilm; and (5) the prevention of tooth or apatitic demineralization. In particular, the presently disclosed subject matter provides a composition for the prevention and treatment of an oral disease (e.g., dental caries) that includes one or more iron oxide nanoparticles and hydrogen peroxide.

Abstract: Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.

Abstract: Systems and methods provide a nonreciprocal nanophotonic modulator. In some examples, the modulator utilizes acoustic pumping, instead of optical pumping with lasers, and is capable of achieving GHz bandwidth.

Abstract: A nerve guidance conduit includes one or more guidance channels formed as porous polymeric structures. The guidance channels are within an outer tubular structure that includes randomly-oriented nanofibers. The guidance channels may have electrospun nanofibers on their inner and outer surfaces in a parallel alignment with the guidance channels. Such aligned nanofibers may also be present on the inner surface of the outer tubular structure. The outer surfaces of the guidance channels and the inner surface of the tubular structure define additional guidance channels. Such a nerve guidance conduit provides augmented surface areas for providing directional guidance and enhancing peripheral nerve regeneration. The structure also has the mechanical and nutrient transport requirements required over long regeneration periods.

Abstract: A quadrupole mass filter and method for operating the filter are described. Sample ions, each having a mass-to-charge ratio, are passed to a quadrupole at least one AC voltage is applied thereto to separate the ions by incrementally varying a frequency of the at least one AC voltage within a first range of frequencies and, for each of at least some of the incremental frequencies in the first range of frequencies, incrementally varying an amplitude of the at least one AC voltage within a range of amplitudes, wherein each incremental frequency and incremental amplitude pair of the at least one AC voltage creates a different band pass filter in the quadrupole through which produced ions having a different corresponding mass-to-charge ratio pass to a detector.

Abstract: A C—C chemokine receptor 3 (CCR3) peptide analog that exhibits biased antagonism by binding to and inhibiting ligand-mediated signaling and chemotaxis while promoting the internalization and degradation of CCR3 is provided as is a method of using the peptide analog to treat, prevent, or ameliorate one or more symptoms of an eosinophil- or CCR3-mediated disease or condition.

Abstract: The disclosure generally relates to reactive electrochemical membranes (REMs); and in particular, to asymmetric reactive electrochemical membranes to be used for aqueous separations and membrane fouling regeneration.

Abstract: Methods, systems, and media for automatically authenticating a user account using multiple services are provided. In accordance with some embodiments of the disclosed subject matter, methods for authenticating a user using multiple services are provided, the methods comprising: receiving, from a client device, first credentials for a target service account; authenticating the target service account based on the first credentials; issuing a redirecting request that directs the client device to at least one vouching service in response to authenticating the target service account; receiving a vouching response indicating that the client device has authenticated a vouching service account with the at least one vouching service, wherein the vouching response includes a vouching token; and providing the client device with access to the target service account in response to determining that the vouching service account is associated with the target service account.

Abstract: Provided herein are nucleic acid sequences that encode novel consensus amino acid sequences of HA hemagglutinin, as well as genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an immune response against one or more Influenza A serotpyes using the vaccines that are provided.

Abstract: Described herein is an approximate dynamic programming (ADP) vector controller for control of a permanent magnet (PM) motor. The ADP controller is developed using the full dynamic equation of a PM motor and implemented using an artificial neural network (ANN). A feedforward control strategy is integrated with the ANN-based ADP controller to enhance the stability and transient performance of the ADP controller in both linear and over modulation regions. Simulation and hardware experiments demonstrate that the proposed ANN-based ADP controller can track large reference changes with high efficiency and reliability for PM motor operation in linear and over modulation regions.

Abstract: Solar rechargeable battery combines the advantages of photoelectrochemical devices and batteries and has emerged as an attractive alternative to artificial photosynthesis for large-scale solar energy harvesting and storage. Due to the low photovoltages by the photoelectrodes, however, most previous demonstrations of unassisted photocharge have been realized on systems with low open circuit potentials (<0.8 V). In response to this critical challenge, here the present disclosure shows that the combined photovoltages exceeding 1.4 V can be obtained using a Ta3N5 nanotube photoanode and a GaN nanowire/Si photocathode with high photocurrents (>5 mA/cm2). The photoelectrode system makes it possible to operate a 1.2 V alkaline anthraquinone/ferrocyanide redox battery with a high ideal solar-to-chemical conversion efficiency of 3.0% without externally applied potentials.

Abstract: Systems for lowering intraocular pressure of glaucoma patients are provided. An exemplary system of lowering intraocular pressure include an adjustable nanoscale plate structure to create an external reservoir. Methods of lowering intraocular pressure using such systems are also provided.