Abstract: A system for, and method of, extracting a surface profile from a stereo pair of images obtained at an arbitrary setting S of an optical system, includes determining surface profile reconstruction parameters for images obtained with the optical system at a reference setting So of the optical system; determining warping parameters for a digital image processor for warping images obtained with the optical system at the arbitrary setting S into images corresponding to the reference setting So; obtaining the stereo pair of images from at least one camera of the optical system; warping the stereo pair of images into images corresponding to the reference setting So, and using the surface profile reconstruction parameters to determine the surface profile. In a particular embodiment, the surface profile is passed to a computer model of tissue deformation and used to determine an intra-surgery location of a tumor or other anatomic feature of tissue.

Abstract: A method for providing an image of a subject is provided. The plurality of Cartesian points is divided into a first group and a second group, wherein all of the Cartesian points in the first group have a kr that is less than or equal to kr of all of the Cartesian points in the second group. The second group is divided into N subgroups. An inversion recovery radio frequency is applied to the subject. K-space data for the first group of Cartesian points for M different time periods is acquired, wherein k-space data is acquired for only one sub-group sequentially and cyclically for the M different time periods. For each time period i of the M different time periods, acquired k-space data for the first group of Cartesian points at time period i and k-space data from N consecutive subgroups of Cartesian points.

Abstract: Disclosed are modulators of the human relaxin receptor 1, for example, of formula (I), wherein A, R1, and R2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e.g., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method for therapeutic intervention in a facet of mammalian health that is mediated by a human relaxin receptor 1.

Abstract: Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.

Abstract: A variety of methods, devices and compositions are implemented for light-activated molecules. One such method is implemented for generating secondary messengers in a cell. A nucleotide sequence for expressing a chimeric light responsive membrane protein (e.g., rhodopsin) is modified with one or more heterologous receptor subunits {e.g., an adrenergic receptor (alpha1, Beta2)}. The light responsive membrane protein is expressed in a cell for producing a secondary messenger in response to light.

Abstract: Methods and apparatus for generating terahertz radiation are disclosed herein. In addition, methods for forming orientation-patterned nonlinear semiconductor crystals are disclosed herein. For example, according to an example implementation, a method for generating terahertz radiation may include: providing an optical pulse having a wavelength less than approximately 1.0 ?m; and illuminating an orientation-patterned nonlinear semiconductor crystal with the optical pulse.

Abstract: Disclosed are devices, systems, apparatus, methods, products, media and other implementations, including a method that includes obtaining hardware-based micro-architectural data, including hardware-based micro-architectural counter data, for a hardware device executing one or more processes, and determining based, at least in part, on the hardware-based micro-architectural data whether at least one of the one or more processes executing on the hardware device corresponds to a malicious process. In some embodiments, determining based on the hardware-based micro-architectural data whether the at least one of the one or more processes corresponds to a malicious process may include applying one or more machine-learning procedures to the hardware-based micro-architectural data to determine whether the at least one of the one or more processes corresponds to the malicious process.

Abstract: Nanoparticles for use as a contrast agent, and methods for making and using the nanoparticles, are described, wherein each nanoparticle comprises a core comprising bismuth and iron oxide, and an outer coating (e.g., dextran) surrounding the core. The bismuth-iron oxide nanoparticles can be used in pre-clinical and clinical settings for both computed tomography (CT) and magnetic resonance (MR) imaging.

Abstract: This present invention provides a novel photoconductive semiconductor switch (PCSS) comprising: a semi-insulating substrate, an anode formed on the upper surface of said semi-insulating substrate, a first n-type doped layer formed on the lower surface of said semi-insulating substrate, a p-type doped layer formed on said first n-type doped layer, a second n-type doped layer formed on said p-type doped layer, a cathode formed on said second n-type doped layer, several recesses facing towards said first n-type doped layer and vertically extending into a part of said first n-type doped layer, an insulating layer formed on said second n-type doped layer and on the walls and the bottoms of said recesses, a gate electrode consisting of two parts, one part of the which formed on said insulating layer on the walls and the bottoms of recesses, and the other part of the which formed on a part of the insulating layer on the second n-type doped layer for electrically connecting the part of the gate electrode on the reces

Abstract: Methods are disclosed for nondestructive testing and measuring the structural health of prestressed concrete structures, such as slabs, columns, girders, bridges, towers, elevated storage tanks, silos, cooling towers, wind power generation towers, liquefied gas storage tanks, nuclear power containment buildings, and the like. Measurements are made as the structure undergoes tensioning and detensioning operations. By measuring actual movements of cardinal points on the structure, in an absolute three-dimensional coordinate system, and comparing the measurements to a model—as tension on a tendon is changed—a margin of safety is assured. High accuracy measurements are made by electronic distance measurement (EDM) instruments over hundreds of meters, which yield coordinates of cardinal points with an uncertainty of the order of one part per million.

Abstract: Systems and techniques are disclosed for flexible, secure energy management that enable control of individual devices in a customer site's energy infrastructure, which can allow optimization (e.g., by minimizing energy cost or usage) across the infrastructure. A system management component may centralize optimization and control capabilities across the energy infrastructure by determining an energy model and directing consumption, storage, and energy draw activities for the totality of the energy infrastructure devices. Systems may include modular, secure terminal devices that can be attached to or paired with the devices in an energy infrastructure in order to provide input data such as power load metrics, as well as to control the operation of the devices. A dynamic, adaptive prediction of system parameters, such as future demand, cost, generation capacity, and other metrics, may be provided. Dynamic, adaptive prediction may be performed without detailed historical usage data.

Abstract: The invention provides novel manganese catalysts such as [Mn(tBuPc)], which are general for the amination of all types of C(sp3)-H bonds (aliphatic, allylic, propargylic, benzylic, ethereal), including strong 1o aliphatic C—H bonds, while achieving excellent chemoselectivity, stereospecificity, and high functional group tolerance. We demonstrate the late-stage diversification of bioactive complex molecules that encompass the range of C(sp3)-H bond types, such as selective 1o C—H aminations of betulinic acid and pleuromutilin derivatives. The catalysts' unprecedented balance of reactivity and selectivity is in part attributed to its mechanism of C—H amination that lies between stepwise and concerted.

Abstract: A system includes a device that is disposed within an environment and is adapted to communicate over a radio frequency communication link. The system also includes a wireless access point disposed within the environment, including a wireless transceiver in communication with the device over a radio frequency communication link using a plurality of channels, and recording a channel state information data set for the radio frequency communication link. The system also includes a monitoring device including a memory storing a plurality of activity profiles, each of which includes an activity and a channel state information profile corresponding to the activity, and a processor receiving, from the wireless access point, the channel state information data set and determining, based on a comparison of the channel state information data set to the channel state information profile of each of the plurality of activity profiles, the activity of the person in the environment.

Abstract: Disclosed are devices, systems, apparatus, methods, products, media and other implementations, including a method that includes obtaining current hardware performance data, including hardware performance counter data, for a hardware device executing a first process associated with pre-recorded hardware performance data representative of the first process' normal behavior, and determining whether a malicious process is affecting performance of the first process based on a determination of an extent of deviation of the obtained current hardware performance data corresponding to the first process from the pre-recorded hardware performance data representative of the normal behavior of the first process.

Abstract: A novel gene “X” of adeno-associated virus is presented, which is found to be an oncogene and to promote efficient production of recombinant AAV virus particles that may be used for human gene therapy. Since the AAV X gene appears to be an oncogene, it is desirable that it not be included in active form in recombinant AAV virus particles. Therefore A therapeutic composition comprising: a plurality of recombinant adeno-associated virus (AAV) virus particles comprising native AAV DNA and recombinant therapeutic DNA, wherein none of the AAV virus particles has an active AAV X gene is presented. Also provided are methods of expressing the X gene to improve production of recombinant AAV virus particles.

Abstract: The invention pertains to a nanoparticle based assay for detecting the presence of a target nucleic acid specific to a fungus. The assay can comprise the steps of obtaining nucleic acids from the sample, contacting the nucleic acids from the sample with a single stranded nucleic acid (ssNA) probe complementary to a target nucleic acid specific for the fungus, and adding nanoparticles to the mixture. The presence of the target nucleic acid and hence the presence of the fungus in the sample is indicated by a particular color associated with aggregated nanoparticles in the solution; whereas, the absence of the target nucleic acid and hence the absence of the fungus in the sample is indicated by a different color associated with dispersed nanoparticles in the solution. Kits comprising nanoparticles and/or ssNA probe are also provided.

Abstract: This invention relates generally to a process and an apparatus therefor for recovering valuable or harmful non-aqueous process liquids from mixtures or slurries that contain such liquids and solid particles. In a first aspect there is provided a filtration process for recovering a substantially non-aqueous process liquid from a feed slurry that predominantly comprises a mixture of the process liquid and solid particles, the process employing a sweep liquid that is less dense than the process liquid.

Abstract: A plurality of camera devices are configured to localize one another based on visibility of each neighboring camera in an image plane. Each camera device captures images and identifies sightings of candidate targets. The camera device share information about sightings and triangulate positions of targets. Targets are matched to known tracks based on prior images, allowing targets to be tracked in a 3D environment.

Abstract: Devices, systems and methods for dynamically stabilizing the spine are provided. The devices include an expandable spacer having an undeployed configuration and a deployed configuration, wherein the spacer has axial and radial dimensions for positioning between the spinous processes of adjacent vertebrae. The systems include one or more spacers and a mechanical actuation means for delivering and deploying the spacer. The methods involve the implantation of one or more spacers within the interspinous space.

Abstract: Various aspects as described herein are directed to apparatuses, methods, and systems including a sandwiched arrangement having a light-access port, a scanning mirror, an optics region, and a spacer. The spacer provides a light-directing optical region that separates the scanning mirror and the optics region, and includes a mirrored surface that reflects light between the light-access port and the optics region. Additionally, the optics region includes a curved-shaped window that provides a field of view by communicating beams of light between a target region. The optics region also includes a curved-shaped mirror having a surface that reflects light between the scanning mirror and the mirrored surface. Light beams, as conveyed between the light-access port and the curved-shaped window, are folded by being reflected off the scanning mirror, the curved-shaped mirror and the mirrored surface.