Abstract: A method of fabricating polyacrylonitrile (PACN) nanostructured carbon superstructure shapes is provided that includes forming a PACN polymer superstructure shape by using as a monomer, an initiator, and a solvent or incorporation of a different co-monomer for free radical polymerization, and converting the PACN polymer superstructure shape to a nanostructured carbon superstructure analogue using stabilization and carbonization of the PACN polymer superstructure shape, where the stabilization includes heating the PACN polymer superstructure shape to a temperature that is adequate to form a stabilization reaction, where the carbonization includes using a heat treatment.

Abstract: Systems and methods for detecting complex networks in MRI image data in accordance with embodiments of the invention are illustrated. One embodiment includes an image processing system, including a processor, a display device connected to the processor, an image capture device connected to the processor, and a memory connected to the processor, the memory containing an image processing application, wherein the image processing application directs the processor to obtain a time-series sequence of image data from the image capture device, identify complex networks within the time-series sequence of image data, and provide the identified complex networks using the display device.

Abstract: Methods for selectively stimulating a plurality of light-responsive neurons in a sample are provided. Methods according to certain embodiments include irradiating a sample comprising a plurality of light-responsive neurons with a plurality of holographic images that are each configured to stimulate one or more light-responsive neurons in the sample, wherein the holographic images are created by light projection system that includes a plurality of light sources; a plurality of optical adjustment components; a plurality of spatial light modulators; a controller; a processor; and a computer-readable medium comprising instructions that, when executed by the processor, cause the controller to operate the light sources, optical adjustment components and spatial light modulators to generate and display a plurality of holographic images; direct each of the holographic images to a projection location; and project the holographic images onto the sample at a rate greater than 1 kHz.

Abstract: Methods and systems are described for determining quantities of interest for particle therapy. An example method can comprise determining one or more first functions indicative of spectral fluence associated with a particle therapy. The one or more first functions can be based on a plurality of simulations of a particle beam. The method can comprise determining, based on the one or more first functions and a second function associated with calculating a quantity, data indicative of the quantity. The method can comprise causing output of the data indicative of the quantity.

Abstract: The present disclosure describes compositions of matter comprising a ribonucleoprotein complex comprising a nucleic acid-guided nuclease and a guide RNA, and further comprising and a blocking nucleic acid molecule represented by Formula I, wherein Formula I in the 5?-to-3? direction comprises: A-(B-L)J-C-M-T-D; wherein A is 0-15 nucleotides in length; B is 4-12 nucleotides in length; L is 3-25 nucleotides in length; J is an integer between 1 and 10; C is 4-15 nucleotides in length; M is 1-25 nucleotides in length or is absent, wherein if M is absent then A-(B-L)J-C and T-D are separate nucleic acid strands; T is 17-135 nucleotides in length and comprises at least 50% sequence complementarity to B and C; D is 0-10 nucleotides in length and comprises at least 50% sequence complementarity to A; and wherein the blocking nucleic acid molecule comprises a sequence complementary to a gRNA.

Abstract: A monocone antenna is described for V2X wireless communications. To achieve ultrawide bandwidth, low-profile, omnidirectional radiation, an implementation comprises various components including a circular monocone, a capacitive feed, a ring with grounding vias, capacitive bars, and conductive cylinders. Another implementation comprises a monocone, a capacitive feed, a ground ring with grounding vias, a plurality of first meander lines, each having a first size, and a plurality of second meander lines each having a second size, wherein the second size is larger than the first size.

Abstract: A fluazifop-resistant sorghum cultivar designated ‘21534_ACCase-R’ and plants comprising a polynucleotide encoding the polypeptide of SEQ ID NO: 39 are disclosed herein. The present invention provides seeds, plants, and plant parts derived from sorghum cultivar ‘21534_ACCase-R’ and those including SEQ ID NO: 39. Further, it provides methods for producing a sorghum plant by crossing ‘21534_ACCase-R’ with itself or another sorghum variety. The invention also encompasses any sorghum seeds, plants, and plant parts produced by the methods disclosed herein, including those in which additional traits have been transferred into ‘21534_ACCase-R’ through the introduction of a transgene or by breeding ‘21534_ACCase-R’ with another sorghum cultivar.

Abstract: Provided herein are methods and compositions for treating inflammatory disease by the administration, to a patient in need thereof, of an inhibitor of IL-2R desensitization in combination with a low dose of IL-2. A low dose of interleukin-2 (IL-2) is sufficient to stimulate regulatory T lymphocytes (Tregs) without substantially inducing effector T lymphocytes (Teffs). In some embodiments, the inhibitor of IL-2R desensitization is a small molecule or drug. Is some embodiments the inhibitor is a NEDD8 activating enzyme (NAE) inhibitor. In some embodiments a combination therapy provides for a synergistic effect, where the combination of the inhibitor of IL-2R desensitization and low dose IL-2 provides an effect that is greater than the sum of either the inhibitor or low dose IL-2 administered as a single agent.

Abstract: Disclosed are methods of treating viral disorders via the administration of an inducing agent and an anti-viral agent. In one embodiment, the inducing agent and the anti-viral agent are administered for about five days, and the anti-viral agent is subsequently administered without the inducing agent for an additional period of about sixteen days for a total cycle of about 21 days.

Abstract: Various embodiments are directed to video-based deep learning evaluation of cardiac ultrasound that accurately identify cardiomyopathy and predict ejection fraction, the most common metric of cardiac function. Embodiments include systems and methods for analyzing images obtained from an echocardiogram. Certain embodiments include receiving video from a cardiac ultrasound of a patient illustrating at least one view the patient's heart, segmenting a left ventricle in the video, and estimating ejection fraction of the heart. Certain embodiments include at least one machine learning algorithm.

Abstract: Inhibitors of Glycerol 3-Phosphate Acyltransferase (GPAT) are provided; and methods of use in the treatment of cancer; and treatment of conditions relating to metabolic syndrome and hyperlipidemia.

Abstract: An integrated circuit on a chip may include a plurality of capacitors that are connected in series and generate an AC noise signal. A selected bandwidth of the AC noise signal transmits through the series of capacitors as a first AC power signal. Respective rectifiers are positioned for receiving a positive cycle of the first AC power signal and a negative cycle of the first AC power signal. Output terminals are connected to the respective rectifiers and configured for connection to an off chip circuit. The capacitors may be fixed or variable gap capacitors.

Abstract: A computerized method includes analyzing program code, including a control flow graph, of one or more applications that are executable by an operating system of a computing device to determine event-logging functions of the program code that generate event logs; extracting, by the processing device based on the event-logging functions, log message strings from the program code that describes event-logging statements; identifying, by the processing device, via control flow analysis, possible control flow paths of the log message strings through the control flow graph; storing, in a database accessible by the processing device, the possible control flow paths; and inputting, by the processing device into a log parser, the possible control flow paths of the log message strings to facilitate interpretation of application events during runtime execution of the one or more applications.

Abstract: A programmable switch includes an input arbiter to analyze packet headers of incoming packets and determine which of the incoming packets are part of gradient vectors received from worker computing devices that are performing reinforcement learning. The programmable switch also includes an accelerator coupled to the input arbiter, the accelerator to: receive the incoming packets from the input arbiter; asynchronously aggregate gradient values of the incoming packets, as the gradient values are received, to generate an aggregated data packet associated with a gradient segment of the gradient vectors; and transfer the aggregated data packet to the input arbiter to be transmitted to the worker computing devices, which are to update local weights based on the aggregated data packet.

Abstract: The present disclosure is directed to methods for preparing nanoparticle monolayers on a sub-phase by controlling the spreading rate of the nanoparticles. The nanoparticles are first prepared in a nanoparticle solution at a predetermined concentration with a solvent. The sub-phase solution is prepared to have a density and viscosity compatible with the desired spreading rate. Additives, such as glycerol, are used to alter the density of the sub-phase solution. A volume of nanoparticle solution is deposited on the surface of the sub-phase solution and allowed to spread in a controlled manner on the unconstrained surface, forming a uniform nanoparticle monolayer. A substrate is then placed in contact with the nanoparticle monolayer to form a uniform nanoparticle coating on the surface of the substrate.

Abstract: Circuits for a receiver, comprising: M first mixers that each receive an input signal, that are each clocked by a different phase of a first common clock frequency, and that each provide an output, wherein M is a count of the first mixers; and M sets of N second mixers, wherein N is a count of the second mixers in each of the M sets, wherein each second mixer in each set of N second mixers receives as an input the output of a corresponding one of the M first mixers, wherein each of the N second mixers in each of the M sets are clocked by a different phase of a second common clock frequency, and wherein each of the second mixers has an output.

Abstract: Surrogates for roadside objects, such as concrete curbs, can be used for vehicle testing. A surrogate for a concrete curb can substantially be similar in size and/or shape as the concrete curb that the surrogate is mimicking. The surrogate can be configured to exhibit substantially the same characteristics as their actual counterpart concrete curb when sensed by one or more vehicle sensors (e.g., cameras, radar sensors, and/or LIDAR sensors). Such surrogates can be used to test automated vehicles, one or more vehicle sensors, a vehicle sensor system, and/or one or more vehicle system (e.g., a road departure mitigation system). The surrogates can be configured to withstand being impacted by a test vehicle without being damaged and without damaging the test vehicle.

Abstract: The present disclosure provides compositions and methods based on the inhibition of thrombospondin-1 as a therapeutic target in aging skeletal muscle to improve muscle mass, strength, function, maintenance, and regeneration.

Abstract: Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.

Abstract: A cooler device includes a cold plate and a manifold with fluid wicking structure. The cold plate includes an array of bonding posts and an array of fluid channels. Each bonding post of the array of bonding posts has a first height and is in contact with the manifold with fluid wicking structure. Each fluid channel of the array of fluid channels has a second height that is less than the first height. The array of fluid channels include a MIO secondary wick structure. The array of bonding posts is orthogonal to the array of fluid channels. The manifold with fluid wicking structure includes a plurality of spacer elements and a plurality of mesh layers. Each one of the plurality of spacer elements alternate with each one of the plurality of mesh layers in a stacked arrangement.