Patents Assigned to Trustees of Boston College
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Publication number: 20200330968Abstract: In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on enhanced hydrogen-bonding capability and the situation of metal centers in cavity-like chiral environments. Also disclosed is an asymmetric system for stereoselective synthesis of cyclopropane and aziridine derivatives. The disclosed Co(II)-based metalloradical system has been shown to have an unusual capability of controlling both the degree and sense of asymmetric induction in cyclopropanation and aziridination reactions in a systematic manner. The disclosed system is applicable to a broad scope of substrates having diazo or azido moieties and exhibits a remarkable profile of reactivity and selectivity, providing access to cyclopropane diastereomers and aziridine enantiomers in highly enantioenriched forms. Also disclosed are catalysts useful in the disclosed processes.Type: ApplicationFiled: April 16, 2020Publication date: October 22, 2020Applicant: Trustees of Boston CollegeInventor: Xiao-Xiang Zhang
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Publication number: 20200316096Abstract: The present disclosure provides a unique novel diet-drug combination, and method thereof, for cancer management, with synergistic and non-toxic effects.Type: ApplicationFiled: April 3, 2020Publication date: October 8, 2020Applicant: Trustees of Boston CollegeInventors: Thomas N. Seyfried, Purna Mukherjee
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Publication number: 20200317627Abstract: In one aspect, the disclosure relates to a mode of asymmetric induction in radical processes based on sequential combination of enantiodifferentiative H-atom abstraction and stereoretentive radical substitution. Also disclosed is an asymmetric system for stereoselective synthesis of strained 5-membered cyclic sulfamides via radical 1,5-C—H amination of sulfamoyl azides. The disclosed metalloradical system can control the degree and sense of asymmetric induction in the catalytic radical C—H amination in a systematic manner. The disclosed system is applicable to a broad scope of substrates with different types of C(sp3)-H bonds and exhibits reactivity and selectivity, providing access to both enantiomers of useful 5-membered cyclic sulfamides in a highly enantioenriched form. Also disclosed are catalysts useful in these processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: ApplicationFiled: April 6, 2020Publication date: October 8, 2020Applicant: Trustees of Boston CollegeInventors: Xiao-Xiang Zhang, Kai Lang
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Patent number: 10717975Abstract: Methods and compositions are described for selecting and identifying orthogonal aminoacyl synthetase-tRNA pairs and their use to incorporate unnatural amino acids in a site-specific manner in proteins. Specifically described is a novel E. coli tyrptophanyl synthetase-tRNA pair that functions as both an opal and amber suppressor and that incorporates tryptophan analogs into proteins.Type: GrantFiled: May 31, 2017Date of Patent: July 21, 2020Assignee: TRUSTEES OF BOSTON COLLEGEInventors: Abhishek Chatterjee, James Italia
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Publication number: 20200216610Abstract: Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.Type: ApplicationFiled: December 2, 2019Publication date: July 9, 2020Applicant: Trustees of Boston CollegeInventors: Jia Niu, Hanchu Huang, Wenqi Wang
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Patent number: 10673094Abstract: The present invention demonstrates Br2-based conversion chemistry is a potential route toward rechargeable Mg-batteries. Compared with Mg-ion or Mg-air chemistries, the Mg—Br2 system features fast kinetics and good cyclability. In one embodiment, the present invention provides a rechargeable non-aqueous, dual-electrolyte scheme. In one embodiment, the anolyte consisted of Mg(TFSI)2 dissolved in a monoglyme and diglyme mixture, whereas the catholyte was composed of Mg(TFSI)2 in PYR14TFSI ionic liquid mixed with active bromine species. When Mg was used as the anode, an open circuit voltage of 3.0 V (vs. Mg2+/Mg) was measured.Type: GrantFiled: March 28, 2018Date of Patent: June 2, 2020Assignee: Trustees of Boston CollegeInventors: Dunwei Wang, Xiahui Yao, Jingru Luo, Qi Dong
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Patent number: 10669636Abstract: An all solution-processed deposition includes a non-water soluble, non-self-cracking film deposited by a solution process (e.g., spray, dip, spin coat, and the like), a water soluble, self-cracking film deposited by a solution process (e.g., spray, dip, spin coat, and the like), cracking of the film, and filling the cracks with a metal that is deposited in solution (e.g., by electroless disposition). A transparent substrate having a cracked water insoluble, non-self-cracking film surface coating includes a plurality of fissures therein extending to and exposing portions of the surface of the underlying transparent substrate is useful for producing a transparent conducting film.Type: GrantFiled: March 10, 2017Date of Patent: June 2, 2020Assignee: The Trustees of Boston CollegeInventors: Michael J. Naughton, Chaobin Yang, Kris Kempa, Michael J. Burns
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Publication number: 20200144429Abstract: Structures and methods for electron-hole photogeneration by plasmonic multiple exciton generation in light absorbing layers and solar cells are disclosed.Type: ApplicationFiled: November 1, 2018Publication date: May 7, 2020Applicant: The Trustees of Boston CollegeInventors: Michael J. Naughton, Krzysztof Kempa
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Patent number: 10584141Abstract: Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether ligand. The heterocyclic ligand significantly enhances the catalytic activity, and the styrenyl ether allows for the easy recovery of the Ru complex. Derivatized catalysts capable of being immobilized on substrate surfaces are also disclosed. The present catalysts can be used to catalyze ring-closing metathesis (RCM), ring-opening (ROM) and cross metatheses (CM) reactions, and promote the efficient formation of various trisubstituted olefins at ambient temperature in high yield.Type: GrantFiled: June 14, 2019Date of Patent: March 10, 2020Assignee: THE TRUSTEES OF BOSTON COLLEGEInventors: Amir H. Hoveyda, Jason Kingsbury, Steven Garber, Brian L. Gray, John T. Fourkas
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Catalysts for metathesis reactions including enantioselective olefin metathesis, and related methods
Patent number: 10569261Abstract: The present invention provides compositions comprising metal complexes, and related methods. In some embodiments, metal complexes of the invention may be useful as catalysts for chemical reactions, including metathesis reactions, wherein the catalysts exhibit enhanced activity and stereoselectivity. In some embodiments, the invention may advantageously provide metal complexes comprising a stereogenic metal atom. Such metal complexes may be useful in enantioselective catalysis.Type: GrantFiled: June 6, 2017Date of Patent: February 25, 2020Assignees: Trustees of Boston College, Massachusetts Institute of TechnologyInventors: Steven J. Malcolmson, Amir H. Hoveyda, Simon J. Meek, Richard R. Schrock -
Publication number: 20190229387Abstract: Solar rechargeable battery combines the advantages of photoelectrochemical devices and batteries and has emerged as an attractive alternative to artificial photosynthesis for large-scale solar energy harvesting and storage. Due to the low photovoltages by the photoelectrodes, however, most previous demonstrations of unassisted photocharge have been realized on systems with low open circuit potentials (<0.8 V). In response to this critical challenge, here the present disclosure shows that the combined photovoltages exceeding 1.4 V can be obtained using a Ta3N5 nanotube photoanode and a GaN nanowire/Si photocathode with high photocurrents (>5 mA/cm2). The photoelectrode system makes it possible to operate a 1.2 V alkaline anthraquinone/ferrocyanide redox battery with a high ideal solar-to-chemical conversion efficiency of 3.0% without externally applied potentials.Type: ApplicationFiled: January 16, 2019Publication date: July 25, 2019Applicant: The Trustees of Boston CollegeInventors: Dunwei Wang, Qingmei Cheng
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Patent number: 10336781Abstract: Highly active, recoverable and recyclable transition metal-based metathesis catalysts and their organometallic complexes including dendrimeric complexes are disclosed, including a Ru complex bearing a 1,3-dimesityl-4,5-dihydroimidazol-2-ylidene and styrenyl ether ligand. The heterocyclic ligand significantly enhances the catalytic activity, and the styrenyl ether allows for the easy recovery of the Ru complex. Derivatized catalysts capable of being immobilized on substrate surfaces are also disclosed. The present catalysts can be used to catalyze ring-closing metathesis (RCM), ring-opening (ROM) and cross metatheses (CM) reactions, and promote the efficient formation of various trisubstituted olefins at ambient temperature in high yield.Type: GrantFiled: October 21, 2015Date of Patent: July 2, 2019Assignee: THE TRUSTEES OF BOSTON COLLEGEInventors: Amir H. Hoveyda, Jason Kingsbury, Steven Garber, Brian L. Gray, John T. Fourkas
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Patent number: 10286001Abstract: The invention provides compositions and methods for utilizing synthetic human milk oligosaccharides as prebiotics.Type: GrantFiled: January 30, 2017Date of Patent: May 14, 2019Assignees: Glycosyn LLC, Trustees of Boston CollegeInventors: David S. Newburg, John M. McCoy, Massimo Merighi, Matthew Ian Heidtman, Zhuoteng Yu
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Patent number: 10193638Abstract: A nanoscale wireless communication system and device operates via in-plane information transmission between a broadcast plasmonic antenna and a receiver plasmonic antenna which mediates a three-step conversion process (surface plasmon?photon?surface plasmon) with in-plane and in-phase efficiency (plasmon?plasmon) in the free-space excitation wavelength for antenna separations in the far-field.Type: GrantFiled: October 2, 2017Date of Patent: January 29, 2019Assignee: The Trustees of Boston CollegeInventors: Michael J. Naughton, Juan M. Merlo-Ramirez
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Patent number: 10173208Abstract: The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.Type: GrantFiled: January 5, 2017Date of Patent: January 8, 2019Assignees: Massachusetts Institute of Technology, Trustees of Boston CollegeInventors: Richard R. Schrock, Annie J. King, Yu Zhao, Margaret M. Flook, Amir H. Hoveyda
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Patent number: 10137429Abstract: The present invention provides novel host-guest complexes, wherein the guest molecule has a diameter larger than the aperture size of the host-a metal organic framework (MOF). The novel host-guest complexes of the invention can be used for drug delivery, sensing, electrical conductivity, luminescence, and energy conversion. The invention also provides a method of making the novel host-guest complex, utilizing the linker exchange conditions in which a guest molecule having a diameter larger than the aperture size of the host is encapsulated into the MOF.Type: GrantFiled: August 17, 2015Date of Patent: November 27, 2018Assignee: THE TRUSTEES OF BOSTON COLLEGEInventors: Chia-Kuang Tsung, Jeffery Byers
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Patent number: 10023971Abstract: The invention provides a novel, template-free process for the fabrication of metal nanowires of novel dimensions. The unconventional method produces highly ordered and freestanding aluminum nanowire arrays.Type: GrantFiled: March 2, 2016Date of Patent: July 17, 2018Assignee: The Trustees of Boston CollegeInventors: Nathan T. Nesbitt, Michael J. Naughton
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Patent number: 9938253Abstract: The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, provided compounds promote highly efficient and highly Z-selective metathesis. In some embodiments, provided compounds and methods are particularly useful for producing allyl alcohols. In some embodiments, provided compounds have the structure of formula I. In some embodiments, provided compounds comprise ruthenium, and a ligand bonded to ruthenium through a sulfur atom.Type: GrantFiled: June 12, 2014Date of Patent: April 10, 2018Assignee: Trustees of Boston CollegeInventors: Amir H. Hoveyda, R. Kashif M. Khan, Sebastian Torker, Ming Joo Koh
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Publication number: 20180097570Abstract: A nanoscale wireless communication system and device operates via in-plane information transmission between a broadcast plasmonic antenna and a receiver plasmonic antenna which mediates a three-step conversion process (surface plasmon?photon?surface plasmon) with in-plane and in-phase efficiency (plasmon?plasmon) in the free-space excitation wavelength for antenna separations in the far-field.Type: ApplicationFiled: October 2, 2017Publication date: April 5, 2018Applicant: The Trustees of Boston CollegeInventors: Michael J. Naughton, Juan M. Merlo-Ramirez
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Patent number: 9850268Abstract: The present application provides, among other things, compounds and methods for metathesis reactions. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and/or stereoselectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and Z-selectivity. In some embodiments, the present disclosure provides methods for preparing alkenyl halide with regioselectivity and E-selectivity. In some embodiments, provided technologies are particularly useful for preparing alkenyl fluorides. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-a. In some embodiments, a provided compound useful for metathesis reactions has the structure of formula II-b.Type: GrantFiled: November 5, 2015Date of Patent: December 26, 2017Assignees: Trustees of Boston College, Massachusetts Institute of TechnologyInventors: Amir H. Hoveyda, Hanmo Zhang, Ming Joo Koh, Richard Royce Schrock