Abstract: The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formula (I)-(XXVI) and (III?) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer, e.g., HCC.
Type:
Grant
Filed:
December 23, 2016
Date of Patent:
October 31, 2017
Assignee:
TRUSTEES OF BOSTON UNIVERISTY
Inventors:
Ulla Hansen, Scott Schaus, Trevor Grant, Joshua Bishop, John Kavouris, Lisa M. Christadore
Abstract: A method for software inspection analyzes a body of computer code to assess whether the body of computer code contains malware. Various embodiments extract the executable elements of the body of computer code and modify those elements using rules defining the format of instructions for the programming language in which the computer code was written, and using rules defined from the security specification of that programming language, to produce a model of the body of computer code. The method then analyzes the model using a model checking system, which determines whether any of the language rules have been violated, in which case the method flags the computer code as potentially including malware.
Type:
Application
Filed:
February 28, 2013
Publication date:
August 28, 2014
Applicant:
Trustees of Boston Univeristy
Inventors:
Mark C. Reynolds, Azer Bestavros, Assaf J. Kfoury
Abstract: The present invention provides new methods for inducing or promoting bone growth and/or for reducing or preventing bone deterioration in a mammal subject. The inventive methods generally comprise administering to the subject an effective amount of a resolvin. In particular, the inventive methods may be useful for treating or preventing conditions associated with bone degradation, deterioration or degeneration such as periodontal disease, osteoarthritis, and metastatic bone disease and osteolytic bone disease. Pharmaceutical compositions and kits comprising at least one resolvin are also provided that can be used to performed the inventive methods.