Patents Assigned to Trustees of Boston University
  • Patent number: 11224371
    Abstract: A neural interface device that comprises an implantable microelectrode body. The implantable microelectrode body includes a neural interface probe, which includes a thin film metal trace connected to an interface pad and an amorphous silicon carbide insulation. The amorphous silicon carbide insulation surrounds the thin film metal trace to form an outside surface of the neural interface probe. The interface pad is exposed to an ambient environment of the neural interface probe through an opening in the amorphous silicon carbide insulation. Methods of manufacturing the neural interface device are disclosed.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: January 18, 2022
    Assignees: Board of Regents, The University of Texas System, Trustees of Boston University
    Inventors: Timothy James Gardner, Stuart F. Cogan
  • Patent number: 11226474
    Abstract: A method for obtaining one or more images of a sample using a microscope includes dividing, using a reverberation cavity, a first one of a plurality of laser pulses into a plurality of sequential sub-pulses, each of the plurality of sequential sub-pulses having a power that is less than a previous one of the plurality of sequential sub-pulses, directing, using the one or more lenses of the microscope, the plurality of sequential sub-pulses onto a portion of the sample to generate a plurality of signals, each of the plurality of signals being associated with a different depth within the sample, and detecting the plurality of signals from the sample to generate one or more images of at least a portion of the sample.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: January 18, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Jerome Charles Mertz, Devin Robert Beaulieu, Thomas Gary Bifano
  • Patent number: 11219384
    Abstract: A passive MRI enhancing embodiment includes a plurality of resonators and increases signal-to-noise ratio of radiofrequency signals emitted by a specimen and captured by an MRI machine. The apparatus increases the magnetic field component of radiofrequency energy during signal transmission from the MRI machine to the specimen, and/or reception of signals from the specimen to the MRI machine. Use of the apparatus improves the images generated by the MRI machine, and/or reduces the time necessary for the MRI machine to capture the image. An isolator embodiment has a nonlinear resonator controllably configurable alternately into an isolation configuration and a transmission configuration, and a second resonator.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: January 11, 2022
    Assignee: Trustees of Boston University
    Inventors: Xin Zhang, Stephan Anderson, Xiaoguang Zhao, Guangwu Duan
  • Patent number: 11203626
    Abstract: The present invention is a DNA expression vector comprising: a toxP; a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of the DNA segment encoding the protein. It is preferred that DNA expression vectors of the present invention include DNA sequences encoding a signal peptide so that a protein expressed is attached to the signal peptide prior to processing. Novel proteins are produced off of the DNA expression vector of the present invention.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: December 21, 2021
    Assignees: The Johns Hopkins University, Trustees of Boston University
    Inventors: William R. Bishai, John R. Murphy, Laurene Cheung, Shashank Gupta, Cynthia K. Bullen
  • Patent number: 11199453
    Abstract: A method includes directing a first plurality of probe laser pulses through a sample, dividing each of the first plurality of probe laser pulses to generate a first interferogram, and generating first image data reproducible as a first phase image of the sample. A plurality of pump laser bursts are directed onto the sample to heat the sample. A second plurality of probe laser pulses are directed through the sample at a predetermined time delay. Each of the second plurality of probe laser pulses are divided to generate a second interferogram. Second image data is generated that is reproducible as a second phase image of the sample. A transient phase shift is determined in the second phase image relative to the first phase image. A vibrational spectroscopy property is determined of the sample based on the transient phase shift, thereby allowing an identification of chemical bond information of within the sample.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: December 14, 2021
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, PURDUE RESEARCH FOUNDATION
    Inventors: Ji-Xin Cheng, Delong Zhang, Lu Lan
  • Publication number: 20210380655
    Abstract: Provided herein is a method to produce relaxin or relaxin analogues or variants and their use in methods of treatment, e.g., in the treatment of a stiffened fibrotic joint.
    Type: Application
    Filed: June 1, 2021
    Publication date: December 9, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Mark W. GRINSTAFF, Jack KIRSCH, William BLESSING
  • Patent number: 11193688
    Abstract: Sensing and control apparatus for a building HVAC system includes interior and boundary sensors, such as cameras and thermal sensors, generating sensor signals conveying occupancy-related features for an area. A controller uses the sensor signals to produce an occupancy estimate and to generate equipment-control signals to cause the HVAC system to supply conditioned air to the area based on the occupancy estimate. The controller includes fusion systems collectively generating the occupancy estimate by corresponding fusion calculations, the fusion systems producing a boundary occupancy-count change based on sensor signals from the boundary sensors, an interior occupancy count based on sensor signals from the interior sensors, and the overall occupancy estimate. Fusion may be of one or multiple types including cross-modality fusion across different sensor types, within-modality fusion across different instances of same-type sensors, and cross-algorithm fusion using different algorithms for the same sensor(s).
    Type: Grant
    Filed: May 23, 2019
    Date of Patent: December 7, 2021
    Assignee: Trustees of Boston University
    Inventors: Janusz L. Konrad, Prakash Ishwar, Thomas D C Little, Michael Gevelber
  • Publication number: 20210361745
    Abstract: The present invention provides compositions and methods for the treatment of diseases and disorders. In some embodiments the compositions and methods involve administration of a microparticle, or composition thereof that includes an antifibrotic.
    Type: Application
    Filed: May 21, 2021
    Publication date: November 25, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, BETHISRAEL DEACONESS MEDICAL CENTER
    Inventors: Mark W. GRINSTAFF, William BLESSING, Amanda WILLIAMSON, Jack KIRSCH, Katherine COOK, Ara NAZARIAN, Edward K. RODRIGUEZ
  • Publication number: 20210356754
    Abstract: A display system includes an optical device configured according to constructive interference for a plurality of wavelengths at a focal length. The display system includes a fiber. The display system includes a controller configured to scan the fiber using a Lissajous scanning method to generate a display. The display can be disposed within a focal plane of the optical device. The controller is configured to modulate light intensity from the fiber. The controller can be configured to form a display image that passes through the optical device. The display system can include an optical combiner configured to reflect the display image from the optical device and form a virtual image. The optical device can be configured to magnify a display image from the display and form a virtual image.
    Type: Application
    Filed: May 5, 2021
    Publication date: November 18, 2021
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Zhaoyi LI, Yao-Wei HUANG, Peng LIN, Ji-Xin CHENG, Federico CAPASSO
  • Publication number: 20210318409
    Abstract: An apparatus, and method of operating the same, include a system for indoor positioning and localization. The apparatus includes a first beacon having a beacon optical detector to receive an optical signal, and a beacon microcontroller. The apparatus includes a zone-positioning unit (ZPU) having an optical source configured to transmit the optical signal, and a ZPU microcontroller. The beacon microcontroller is configured to identify and decode the optical signal after receipt by the beacon optical detector to determine data related to a position of the ZPU. The beacon microcontroller is further configured to wirelessly communicate with the ZPU microcontroller to convey information to the ZPU including the data related to a position of the ZPU and a known position of the first beacon. The ZPU microcontroller is configured to determine a position of the ZPU based on the information received from the first beacon.
    Type: Application
    Filed: April 8, 2021
    Publication date: October 14, 2021
    Applicant: Trustees of Boston University
    Inventors: Emily W. LAM, Thomas D.C. LITTLE
  • Publication number: 20210317114
    Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.
    Type: Application
    Filed: March 19, 2021
    Publication date: October 14, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Arturo VEGAS, Sean QUINNELL, Daniel SHEEHY, Kelly TAN, Luke CEO, Stephen Thomas NESTOR, Angela Nicole KOEHLER, Becky LEIFER, Shelby DOYLE
  • Patent number: 11137343
    Abstract: An apparatus, and method of operating the same, detects changes in biomass accumulating on a surface of a substrate while minimizing bulk effect. The apparatus includes a sensor substrate and two illumination sources. A first illumination source generates a first light having a first central wavelength. A second illumination source generates a second light having a second central wavelength different than the first wavelength. The first and second light are mixed to produce a combined light. An analyte solution is introduced to the sensor substrate. Incident light of the combined light is reflected from the sensor substrate to produce a signal. The signal is imaged with a camera to obtain a reflectance. Reflectance produced by the combined light is not affected by variations in the dielectric properties of the analyte solution. A biomass accumulated on the substrate is computed based on the reflectance.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: October 5, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: M. Selim Ünlü, Celalettin Yurdakul, Allison Marie Marn
  • Patent number: 11136620
    Abstract: The invention features a fully-integrated rapid molecular diagnostic device that is low-cost, easy to manufacture, and simple to use. The device can serve as a molecular diagnostic platform for any disease, requiring little or no preparation or customization and can be made from simple materials (e.g., paper and adhesive film), making it inexpensive, portable, and disposable. The invention also provides methods of using the device for detection of one or more targets in a sample.
    Type: Grant
    Filed: December 12, 2016
    Date of Patent: October 5, 2021
    Assignee: Trustees of Boston University
    Inventors: Catherine M. Klapperich, Natalia M. Rodriguez, Jacqueline C. Linnes
  • Publication number: 20210290949
    Abstract: Implantable nerve cuffs and methods for constructing or manufacturing the same are provided. Also provided is a method for installing a nerve into a nerve passage in the nerve cuff and a system using the nerve cuff. The nerve cuff is configured to retain one or more signal carrying elements such as electrodes proximal to a peripheral nerve in a human or animal subject. The nerve cuff may be constructed using a 3D printing method.
    Type: Application
    Filed: July 27, 2017
    Publication date: September 23, 2021
    Applicants: GALVANI BIOELECTRONICS LIMITED, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Bradley J. HOLINSKI, Timothy GARDNER, Charles A. LISSANDRELLO, Alice E. WHITE, Winthrop GILLIS, Jun SHEN, Timothy OTCHY, Christos MICHAS
  • Patent number: 11124769
    Abstract: This disclosure provides methods of making a megakaryocyte-erythroid progenitor cell (MEP), comprising differentiating a MEP precursor cell into a MEP in culture in the presence of an aryl hydrocarbon receptor (AhR) modulator. In some embodiments the AhR modulator is an AhR antagonist. In some embodiments the AhR modulator is an AhR agonist. In some embodiments the methods comprise culturing MEP precursor cells in the presence of an AHR antagonist and then culturing MEP precursor cells in the presence of an AHR agonist. In some embodiments the stem cell is a pluripotent stem cell. In some embodiments the MEP co-expresses CD41 and CD235. In some embodiments the number of MEPs produced in the culture increases exponentially. Methods of making a red blood cell (RBC) by culturing a MEP in the presence of an AhR modulator are also provided. Methods of making a megakaryocyte and/or a platelet, comprising culturing a MEP in the presence of an AhR modulator are also provided.
    Type: Grant
    Filed: February 17, 2018
    Date of Patent: September 21, 2021
    Assignees: BOSTON MEDICAL CENTER CORPORATION, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: George J. Murphy, David H. Sherr, Sarah S. Rozelle, Brenden W. Smith
  • Patent number: 11124846
    Abstract: The invention provides novel and versatile classes of riboregulators, including inter alia activating and repressing riboregulators, switches, and trigger and sink RNA, and methods of their use for detecting RNAs in a sample such as a well and in modulating protein synthesis and expression.
    Type: Grant
    Filed: July 14, 2015
    Date of Patent: September 21, 2021
    Assignees: President and Fellows of Harvard College, Trustees of Boston University
    Inventors: Alexander A. Green, Peng Yin, James J. Collins, Jongmin Kim
  • Patent number: 11124785
    Abstract: There are gluten-degrading enzymes found in Rothia species bacteria that are subtilisins that belonging to the S8A family of serine protease family. The Rothia sp. derived subtilisin-like enzymes have the conserved catalytic triad composed of a Ser, His, and Asp residues that is characteristic of the serine protease family. The Rothia subtilisin enzymes are potent at cleaving proline-containing proteins, cleaving the second peptide bond after proline in the XPX1 motif, where X is any amino acid, P is proline and X1 is a hydrophobic amino acid, e.g. the XPQ motif, where Q is glutamine. Embodiments herein provide isolated enzyme compositions and formulations comprising subtilisins gluten-degrading enzyme from a Rothia species bacteria. Also provided herein are methods of treatment of celiac disease or a related disorder, treatment of gluten-containing foodstuff, degrading and/or detoxifying gluten comprising the subtilisins gluten-degrading enzyme and/or compositions.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: September 21, 2021
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Eva J. Helmerhorst, Guoxian Wei, Na Tian, Detlef Schuppan
  • Publication number: 20210259585
    Abstract: Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of nicotine. Also disclosed herein is a wearable nicotine biosensor device and a biosensor that detects nicotine in smoke. The biosensor disclosed herein comprises a nicotine-catalyzing enzyme, such as NicA2 or mutant NicA2 enzymes. Also described herein are systems comprising said amperometric biosensor, e.g., chronoamperometric biosensor and methods of using said chronoamperometric biosensor.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: James GALAGAN, Mark W. GRINSTAFF, Uros KUZMANOVIC, Mingfu CHEN, Margarita Alexandrovna TARARINA, Karen Nazaretian ALLEN
  • Publication number: 20210262969
    Abstract: Described herein are systems, assays, methods and compositions for identification of oxidase microbial redox-enzymes (MREs) specific to an analyte of interest from an environmental source. The technology relates to identification of analyte-responsive MREs that can quantify the concentration of a target analyte with high specificity and high sensitivity, for example, where the identified analyte-responsive redox-enzyme can be used to engineer an electrochemical biosensor.
    Type: Application
    Filed: February 5, 2021
    Publication date: August 26, 2021
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: James GALAGAN, Uros KUZMANOVIC, Luis ORTIZ, Douglas DENSMORE, Nicolas Shijie SHU
  • Publication number: 20210254016
    Abstract: Described herein is a method of generating in-vitro differentiated airway basal cells and compositions thereof. Also described herein is a method of treating a pulmonary disease comprising administering the in-vitro differentiated airway basal cells and compositions thereof. In another aspect, described herein is a disease model comprising patient-derived or genetically modified in-vitro differentiated airway basal cells and compositions thereof.
    Type: Application
    Filed: February 19, 2021
    Publication date: August 19, 2021
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Finn Joseph HAWKINS, Darrell N. KOTTON, Shingo SUZUKI, Brian R. DAVIS, Cristina BARILLÀ