Patents Assigned to Trustees of Boston University
  • Publication number: 20180267065
    Abstract: Described herein are methods for measuring analytes, wherein a portion of the analyte in a sample is bound by a binding protein. In some embodiments, the methods relate to measuring vitamin D or metabolites thereof, e.g., vitamin D in samples also comprising a vitamin D binding protein.
    Type: Application
    Filed: March 15, 2018
    Publication date: September 20, 2018
    Applicant: Trustees of Boston University
    Inventor: Michael Francis Holick
  • Patent number: 10076460
    Abstract: A method and wearable system and for enhancing human balance and gait and preventing foot injury through neurological stimulation of the foot and the ankle. Subthreshold stimulation for neurosensory enhancement is provided via electrodes or vibrational actuators, or combination thereof, disposed in or on a wearable a platform, such as an insole, sock shoe, removable shoe insert, or applied without the support of a platform, to the skin surface of an individual. Suprathreshold stimulation for therapeutic purposes, such as improving blood flow, is also provided by the vibrational actuators. The actuators and electrodes are driven by bias signals generated by a bias signal generator that is coupled to a controller. The signal generator under the control of the controller is adapted to generate a non-deterministic random signal, a repetitive pattern or series of patterns.
    Type: Grant
    Filed: November 12, 2012
    Date of Patent: September 18, 2018
    Assignee: Trustees of Boston University
    Inventors: Jason D. Harry, James J. Collins, James B. Niemi, Attila A. Priplata, Stephen J. Kleshinski
  • Publication number: 20180245075
    Abstract: Provided herein are engineered systems and methods for establishing DNA adenine methylation at specific genomic locations and using DNA adenine methylation as an artificial chemical “handle” on the genome. These systems and methods allow for placing the handle on specific genomic locations as well as molecular technologies to bind, spatially spread, and maintain the handle. The systems described herein comprise, in some embodiments, three functional modules that mediate m6A operations: (1) a synthetic initiator module to place m6A at specific genomic sites; (2) a synthetic readout module to program m6A recognition and m6A-dependent transcriptional logic; and (3) propagation module that implements “read-write,” a mechanism proposed to underlie chromatin spreading and epigenetic maintenance across cellular systems.
    Type: Application
    Filed: February 6, 2018
    Publication date: August 30, 2018
    Applicant: Trustees of Boston University
    Inventors: Ahmad S. KHALIL, Albert J. KEUNG, Minhee PARK
  • Publication number: 20180245097
    Abstract: Provided herein are opto-genetic systems, cells, and methods thereof for modulating and regulating genetic expression in transiently active cells. The technologies described herein provide a transformative genetic regulatory tool for in vivo applications, which broadly spans a variety of disciplines, including behavioral, cognitive, and systems neuroscience.
    Type: Application
    Filed: February 28, 2018
    Publication date: August 30, 2018
    Applicant: Trustees of Boston University
    Inventor: Adam Tyler Vogel
  • Publication number: 20180246099
    Abstract: Provided herein are methods and compositions relating, in part, to the generation and isolation of human lung progenitor cells from pluripotent stem cells.
    Type: Application
    Filed: February 22, 2018
    Publication date: August 30, 2018
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. Kotton, Finn Hawkins
  • Publication number: 20180231715
    Abstract: The invention provides a device comprising a movable micromirror adapted to receive light from one or more light source(s) and manipulate the reflected light. The micromirror can be actuated electrothermally. In particular, the micromirror is adapted to do at least one of: (a) tipping along a first axis; (b) tilting along a second axis; (c) changing focal length (i.e., varifocal mode); and (d) elevating (i.e., piston mode). The invention also provides a system comprising at least one device comprising a movable micromirror and at least one light source. The invention can be used in smart lighting applications.
    Type: Application
    Filed: July 22, 2016
    Publication date: August 16, 2018
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: David J. Bishop, Thomas Little, Jessica Morrison, Matthias Imboden
  • Patent number: 10040856
    Abstract: Provided herein are novel compositions comprising anti-DEspR antibodies and fragments thereof, including fully human, composite engineered human, humanized, monoclonal, and polyclonal anto-DEspR antibodies and fragments thereof, and methods of their use in a variety of therapeutic applications. The compositions comprising the anti-DEspR antibodies and fragments thereof described herein are useful in diagnostic and imaging methods, such as DEspR-targeted molecular imaging of angiogenesis, and for companion diagnostic and/or in vivo-non invasive imaging and/or assessments.
    Type: Grant
    Filed: June 4, 2015
    Date of Patent: August 7, 2018
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Nelson Ruiz-Opazo, Victoria L. M. Herrera
  • Patent number: 10041044
    Abstract: As demonstrated herein, a preferential and progressive expansion of a subset of hematopoietic cells bearing somatic mutations in TET2 leads to pro-inflammatory IL-1? signaling at multiple levels, including increased IL-1? transcription, increased NLRP3 inflammasome-mediated IL-1? secretion, and increased IL-1-Receptor 1-mediated IL-1? signaling. Accordingly, provided herein are compositions, methods, and assays for modulating TET2 mutation-mediated IL-1? (interleukin-1?) proinflammatory activity, particularly when caused by somatic mutations in TET2.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: August 7, 2018
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Kenneth Walsh, Jose Fuster
  • Publication number: 20180208903
    Abstract: The technology described herein relates to methods and kits for directed differentation of primordial NKX2-1+ lung progenitors along proximal differentiation pathways into functional airway epithelial cells and airway organoids (“bronchospheres”) or along distal lineage pathways using modulation of Wnt signaling. Other aspects relate cell lines, methods, assays and kits comprising airway epithelial cells, and assays for diagnosing a disease that affects swelling of the bronchospheres, and/or for assessing genetic lesions and/or drugs for treating the the disease, where the disease is cystic fibrosis. Other aspects relate to personalized medicine and methods of treatment of cystic fibrosis using the airway epithelial cells.
    Type: Application
    Filed: January 9, 2018
    Publication date: July 26, 2018
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Darrell N. KOTTON, Katherine B. McCauley, Finn HAWKINS
  • Publication number: 20180207196
    Abstract: The methods and assays described herein relate to detection, diagnosis, and treatment of lung cancer, e.g., by detecting the level of expression of certain miRNAs described herein and/or by therapeutically increasing the level of those miRNAs.
    Type: Application
    Filed: January 23, 2018
    Publication date: July 26, 2018
    Applicant: Trustees of Boston University
    Inventors: Ana Brandusa Pavel, Joshua David Campbell, Marc Elliott Lenburg, Avrum Spira
  • Patent number: 10018817
    Abstract: Embodiments of the invention provide an imaging system and method using adaptive optics and optimization algorithms for imaging through highly scattering media in oil reservoir applications and lab-based petroleum research. Two-/multi-photon fluorescence microscopy is used in conjunction with adaptive optics for enhanced imaging and detection capabilities in scattering reservoir media. Advanced fluorescence techniques are used to allow for super-penetration imaging to compensate for aberrations both in and out of the field of interest, extending the depth at which pore geometry can be imaged within a rock matrix beyond the current capability of confocal microscopy. The placement of a Deformable Mirror or Spatial Light Modulator for this application, in which scattering and index mismatch are dominant aberrations, is in an optical plane that is conjugate to the pupil plane of the objective lens in the imaging system.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: July 10, 2018
    Assignees: ARAMCO SERVICES COMPANY, SAUDI ARABIAN OIL COMPANY, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Thomas Bifano, Shannon L. Eichmann, Bennett B. Goldberg, Mazen Kanj, Hari P. Paudel, William Shain
  • Patent number: 10011875
    Abstract: Described herein are methods for the diagnosis, prognosis, and treatment of neurological conditions, e.g. Huntington's Disease, relating to the misregulation of miRNAs in such conditions.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: July 3, 2018
    Assignee: Trustees of Boston University
    Inventors: Richard H. Myers, Andrew Hoss, Vinay Krishna Kartha
  • Patent number: 10004800
    Abstract: The present invention relates, in general, to HIV-1 and, in particular, to broadly neutralizing HIV-1 antibodies, and to HIV-1 immunogens and to methods of using such immunogens to induce the production of broadly neutralizing HIV-1 antibodies in a subject (e.g., a human).
    Type: Grant
    Filed: September 12, 2013
    Date of Patent: June 26, 2018
    Assignees: Duke University, Los Alamos National Security, LLC, The Trustees of The University of Pennsylvania, Trustees of Boston University, The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Barton F. Haynes, Hua-Xin Liao, Rebecca M. Lynch, Tongqing Zhou, Feng Gao, Scott Boyd, George M. Shaw, Beatrice H. Hahn, Thomas B. Kepler, Bette T. Korber, Peter Kwong, John Mascola
  • Patent number: 10004695
    Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
    Type: Grant
    Filed: April 8, 2015
    Date of Patent: June 26, 2018
    Assignee: Trustees of Boston University
    Inventors: Bjoern Markus Reinhard, Suryaram Gummuluru
  • Publication number: 20180163195
    Abstract: The technology described herein relates to controlled chemically- or light-induced rejoinder of split-recombinases. In some embodiments, compositions, methods, kits and systems are provided that relate to a split-recombinase system, whereby protein complementation or rejoinder of split-recombinases is mediated by chemical-induced dimerization domains (CIDDs) or light-induced dimerization domains (LIDD) and rejoinder of the split-recombinases occur in the presence of one or more chemical inducers or light inducers, respectively. The split-recombinases systems as disclosed herein can be used in gene therapy, integrated logic and memory in living cells such as mammalian cells. The nucleic acid cassettes, switches, and systems described herein allow for controlled gene expression or gene regulation. The controlled chemically- or light-induced rejoinder of split-recombinases can be used in, for example, adopted T-cell therapy.
    Type: Application
    Filed: December 12, 2017
    Publication date: June 14, 2018
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Wilson W. WONG, Benjamin Harris WEINBERG
  • Patent number: 9993577
    Abstract: The inventions provided herein relate to dissolvable hydrogel compositions and methods of uses, e.g., but not limited to, in wound management. Accordingly, methods for wound management involving the dissolvable hydrogel compositions are also provided herein. In some embodiments, the dissolvable hydrogel composition comprises an adhesive thioester hydrogel, which can facilitate adherence of the dissolvable hydrogen composition to a surface (e.g., a wound) and can be controllably dissolved later upon addition of a thiolate compound to release the dissolvable hydrogel composition from the surface (e.g., the wound).
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: June 12, 2018
    Assignee: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Cynthia Ghobril, Michel Christophe Wathier, Marlena Dagmara Konieczynska
  • Publication number: 20180155758
    Abstract: A system and method for antibiotic susceptibility testing efficiently determines whether bacteria are alive or have been killed by antibiotic treatment. The antibiotic susceptibility testing device includes at least one reservoir into which a bacteria solution is introduced and a microfluidic channel connected to the reservoir, wherein the cross-sectional size of the microfluidic channel is selected to be comparable to the size of the bacterium to be tested. Furthermore, the electrical resistance or voltage signal across the microchannel is monitored as bacteria swim into and out of the channel. Alternatively, a small population of bacteria can be immobilized in the microchannel. The resistance or voltage signal fluctuates when the bacteria are alive and moving in and out of the channel or wiggling on the microchannel walls. If the bacteria are dead, they have limited motility and the signal fluctuations are significantly smaller.
    Type: Application
    Filed: February 2, 2018
    Publication date: June 7, 2018
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Kamil Ekinci, Le Li, Chuanhua Duan, Vural Kara, Deborah Stearns-Kurosawa
  • Publication number: 20180142247
    Abstract: The present invention provides nucleic acid molecules, DNA constructs, plasmids, and methods for post-transcriptional regulation of gene expression using RNA molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive RNA or crRNA) within the 5? untranslated region (5? UTR) of an mRNA molecule. The nucleic acid element forms a hairpin (stem/loop) structure through complementary base pairing. The hairpin blocks access to the mRNA transcript by the ribosome, thereby preventing translation. In particular, in embodiments of the invention designed to operate in prokaryotic cells, the stem of the hairpin secondary structure sequesters the ribosome binding site (RBS). In embodiments of the invention designed to operate in eukaryotic cells, the stem of the hairpin is positioned upstream of the start codon, anywhere within the 5? UTR of an mRNA.
    Type: Application
    Filed: November 30, 2016
    Publication date: May 24, 2018
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: James J. Collins, Farren J. Isaacs, Charles R. Cantor, Daniel J. Dwyer
  • Patent number: 9979038
    Abstract: System and method for energy storage and recovery is described. More particularly, system and method using tungsten based materials to electrochemically store and recover energy is described. In certain embodiments, the system includes a reversible solid oxide electrochemical cell (RSOEC) having a porous cathode, a porous anode, and an electrolyte capable of transporting oxygen ion. The system further includes a reactor comprising tungsten, tungsten oxide, or combinations thereof. To store the energy, the RSOEC is capable of receiving electricity to electrolyze H2O to generate H2 and O2 and the reactor is operably connected to the RSOEC to receive the generated H2 and convert tungsten oxide to tungsten thereby storing electrical energy. To recover the energy, reactor is capable of receiving H2O to convert tungsten to tungsten oxide and generate H2 and the RSOEC is operably connected to the reactor to receive the generated H2 and generate electrical energy.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: May 22, 2018
    Assignee: Trustees of Boston University
    Inventors: Uday B. Pal, Srikanth Gopalan
  • Patent number: 9957511
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: May 1, 2018
    Assignees: Massachusetts Institute of Technology, Trustees of Boston University
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom