Patents Assigned to Trustees of Boston University
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Publication number: 20240247261Abstract: Provided herein are methods, compositions and systems comprising synthetic nucleic acid molecules that enable inducible or conditional pri-miRNA processing, preferably in mammalian cells in vivo. Provided herein are synthetic nucleic acid molecules referred to as Orthogonal RNA Interference induced by Trigger RNA (ORIENTR) that switches between an inactive form and an active form upon interaction with one or more specific RNA-trigger molecules, which can be e.g., a synthetic RNA-trigger, or a disease-specific RNA signals, such as disease-specific mRNA, miRNA, or other cellular RNA products with sequences that characterize a disease state of a cell. The interaction between the RNA-trigger molecules and the ORIENTR is preferably mediated by hybridization, which exposes, facilitates the formation, and/or allows the formation of a correctly folded pri-miRNA scaffold substrate that can be processed by proteins of the RNAi pathway (such as Dicer), leading to RNAi-mediated repression of a target gene.Type: ApplicationFiled: December 21, 2023Publication date: July 25, 2024Applicants: TRUSTEES OF BOSTON UNIVERSITY, UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATEDInventors: Alexander Arthur Green, Yu Zhou, Peike Sheng, Mingyi Xie
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Patent number: 12043621Abstract: The technology described herein is directed to IL-4 and/or IL-13 inhibitors and uses thereof.Type: GrantFiled: March 19, 2021Date of Patent: July 23, 2024Assignees: Trustees of Boston University, Massachusetts Institute of TechnologyInventors: Arturo Vegas, Sean Quinnell, Daniel Sheehy, Kelly Tan, Luke Ceo, Stephen Thomas Nestor, Angela Nicole Koehler, Becky Leifer, Shelby Doyle
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Publication number: 20240219315Abstract: A substrate inspection apparatus includes a light irradiator including an objective lens and a plurality of optical fibers. The objective lens is configured to irradiate light to an illumination area on a semiconductor substrate having a plurality of circuit pattern layers, the plurality of optical fibers are adjacent a periphery of the objective lens and are configured to irradiate the light to a peripheral area adjacent the illumination area. A light generator is configured to generate the light. The light generator is configured to change an irradiation angle of the light to selectively irradiate the light to one or more of the objective lens and the plurality of optical fibers. A light analyzer is configured to obtain images of the circuit pattern layers from the light reflected from the illumination area and the peripheral area.Type: ApplicationFiled: October 24, 2023Publication date: July 4, 2024Applicants: Samsung Electronics Co., Ltd., Trustees of Boston UniversityInventors: Jangwoon Sung, Lei Tian, Hao Wang, Jiabei Zhu, Myungjun Lee, Wookrae Kim, Seungbeom Park, Junho Shin, Hojun Lee
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Publication number: 20240218194Abstract: Methods and compositions for 3D and 4D printing inks exhibit desirable electrical and rheological properties. The compositions disclosed include a 3D printing ink employing a liquid metal emulsion and a method of creating a stretchable electronic device using the same. The compositions also include 4D printing inks and methods of tuning said inks to have desirable properties.Type: ApplicationFiled: December 22, 2023Publication date: July 4, 2024Applicant: Trustees of Boston UniversityInventors: John William Boley, Javier M. Morales Ferrer, Stephanie Flores Zopf, Chloe Grace Kekedjian, Ramon Enrique Sanchez Cruz
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Publication number: 20240197860Abstract: The technology described herein is directed to compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA (saRNA). Also described herein are compositions and methods for modifying and controlling the activity of cells by expression of proteins from self-amplifying RNA that is substituted with chemically modified nucleotides.Type: ApplicationFiled: November 17, 2023Publication date: June 20, 2024Applicant: Trustees of Boston UniversityInventors: Joshua Edward MCGEE, Jack Rainier KIRSCH, Eric BRESSLER, Mark W. GRINSTAFF, Wilson WONG, Lidya Yidnekachew Sertse, Kexin Li
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Patent number: 11994687Abstract: A display system includes an optical device configured according to constructive interference for a plurality of wavelengths at a focal length. The display system includes a fiber. The display system includes a controller configured to scan the fiber using a Lissajous scanning method to generate a display. The display can be disposed within a focal plane of the optical device. The controller is configured to modulate light intensity from the fiber. The controller can be configured to form a display image that passes through the optical device. The display system can include an optical combiner configured to reflect the display image from the optical device and form a virtual image. The optical device can be configured to magnify a display image from the display and form a virtual image.Type: GrantFiled: May 5, 2021Date of Patent: May 28, 2024Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, TRUSTEES OF BOSTON UNIVERSITYInventors: Zhaoyi Li, Yao-Wei Huang, Peng Lin, Ji-Xin Cheng, Federico Capasso
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Patent number: 11993763Abstract: A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port. A metamaterial scaffold including a structure defining a lumen, at least a portion of an outer or non-lumen surface of the structure is coated with a plurality of biological cells, and wherein the structure is composed of a metamaterial.Type: GrantFiled: December 23, 2020Date of Patent: May 28, 2024Assignee: TRUSTEES OF BOSTON UNIVERSITYInventors: Christos Michas, Anant Chopra, Alice Elizabeth White, Christopher S. Chen
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Publication number: 20240156696Abstract: The present disclosure relates to compositions and methods for restoring enamel, e.g., on tooth surfaces.Type: ApplicationFiled: November 16, 2023Publication date: May 16, 2024Applicant: Trustees of Boston UniversityInventors: Yuwei FAN, Lina Fahad N. MENGARI, Zhi SUN
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Patent number: 11982615Abstract: Systems and methods are provided for performing photothermal dynamic imaging. An exemplary method includes: scanning a sample to produce a plurality of raw photothermal dynamic signals; receiving the raw photothermal dynamic signals of the sample; generating a plurality of second signals by matched filtering the raw photothermal dynamic signals to reject non-modulated noise; and performing an inverse operation on the second signals to retrieve at least one thermodynamic signal in a temporal domain.Type: GrantFiled: March 28, 2023Date of Patent: May 14, 2024Assignee: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Lu Lan, Jiaze Yin
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Patent number: 11977076Abstract: The present invention provides methods for diagnosis and prognosis of lung cancer using expression analysis of one or more groups of genes, and a combination of expression analysis from a nasal epithelial cell sample. The methods of the invention provide far less invasive method with a superior detection accuracy for lung cancer when compared to any other currently available method for lung cancer diagnostic or prognosis. The invention also provides methods of diagnosis and prognosis of other lung diseases, such as lung cancer.Type: GrantFiled: September 23, 2019Date of Patent: May 7, 2024Assignee: Trustees of Boston UniversityInventors: Jerome S. Brody, Avrum Spira, Jeffrey S. Berman, Anthony W. O'Regan
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Publication number: 20240139242Abstract: The technology described herein is directed to compositions comprising components of multi-component CALs or CARs, e.g., a TCR recognition domain; and one or both of: (a) an intracellular signaling domain; and (b) a first-type protein interaction domain. Further provided herein are methods for treating or preventing an autoimmune disease, a transplant rejection, or graft versus host disease.Type: ApplicationFiled: October 16, 2020Publication date: May 2, 2024Applicants: TRUSTEES OF BOSTON UNIVERSITY, THE GENERAL HOSPITAL CORPORATIONInventors: Mohammadreza PAKYARI, Wilson WONG, Atsushi OKUMA, Curtis CETRULO
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Publication number: 20240131029Abstract: The present disclosure provides methods and compositions for treating a condition associated with impaired lymphatic drainage.Type: ApplicationFiled: February 3, 2022Publication date: April 25, 2024Applicants: President and Fellows of Harvard College, Trustees of Boston UniversityInventors: Esak Lee, Christopher S. Chen
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Patent number: 11965009Abstract: The present invention is a DNA expression vector comprising: a toxP: a mutant toxO that blocks Fe-mediated regulation of gene expression; and a DNA sequence encoding a protein, wherein the toxP and the mutant toxO regulate expression of the DNA segment encoding the protein. It is preferred that DNA expression vectors of the present invention include DNA sequences encoding a signal peptide so that a protein expressed is attached to the signal peptide prior to processing. Novel proteins are produced off of the DNA expression vector of the present invention.Type: GrantFiled: December 13, 2021Date of Patent: April 23, 2024Assignees: The Johns Hopkins University, Trustees of Boston UniversityInventors: William R. Bishai, John R. Murphy, Laurene Cheung, Shashank Gupta, Cynthia K. Bullen
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Publication number: 20240110185Abstract: The methods and compositions described herein are directed to regulated synthetic gene expression systems. In particular, the technology described herein relates to compositions, systems and methods for inducible and transient (e.g., reversible) transcriptional repression of a target transcript of interest (GOI). The methods, compositions and systems described herein relate to engineered synthetic transcription factors (synTF) that are activated by an inducer molecule, which induces the transcription of a repressor or gene editing molecule from a synthetic inducible repressor constructs where the antisense repressor (or gene editing molecule) mediates reversible repression of a target transcript of interest (GOI) in the presence of the inducer.Type: ApplicationFiled: August 15, 2023Publication date: April 4, 2024Applicant: Trustees of Boston UniversityInventors: Michael Howard RAYMOND, Ahmad S. KHALIL
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Publication number: 20240099614Abstract: Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.Type: ApplicationFiled: September 6, 2023Publication date: March 28, 2024Applicant: Trustees of Boston UniversityInventors: James Galagan, Uros Kuzmanovic, Abdurrahman Addokhi
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Patent number: 11940580Abstract: A system for near-surface geophysical subsurface imaging for detecting and characterizing subsurface heterogeneities comprises an instrument that outputs probing electromagnetic signals through a ground surface that interact and are affected by scattered signals of acoustic waves that travel through the ground surface and further senses vibrational modes of a subsurface below the ground surface; an imaging device that dynamically generates a time sequence of images of properties of the acoustic waves and maps elastic wave fields of the acoustic waves; and a processor that analyzes dynamic multi-wave data of the images to quantify spatial variations in the mechanical and viscoelastic properties of the subsurface.Type: GrantFiled: October 10, 2019Date of Patent: March 26, 2024Assignees: Massachusetts Institute of Technology, The Trustees of Boston UniversityInventors: Stephen Brown, Thomas Szabo, Daniel R. Burns, Michael Fehler
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Patent number: 11933864Abstract: A system and method of effectively measuring a change in a gradient of a magnetic field. The systems include a first magnet and a second magnet mechanically coupled together and aligned along a polarization axis. The first magnet and the second magnet are positioned such that a pair of like magnetic poles of the first magnet and the second magnet face in opposite directions. Further, the first magnet and the second magnet are configured to move along the polarization axis in response to a magnetic field. A sensing system is configured to measure a change in a gradient of the magnetic field based on the movement of the first magnet and second magnet along the polarization axis in response to the magnetic field.Type: GrantFiled: May 18, 2023Date of Patent: March 19, 2024Assignee: Trustees of Boston UniversityInventors: Joshua Javor, David Bishop, David Campbell, Matthias Imboden
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Patent number: 11913881Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.Type: GrantFiled: January 23, 2023Date of Patent: February 27, 2024Assignee: Trustees of Boston UniversityInventors: Ji-Xin Cheng, JIan Zhao, Lei Tian, Alex Matlock
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Publication number: 20240053264Abstract: A mid-infrared photothermal microscopy system images a sample. A mid-infrared optical source generates a mid-infrared beam which is directed along a first optical path to reach the substrate on a first side and heat the sample. A probe light source generates a probe light which is directed along a second optical path to reach the substrate on a second side and illuminate the sample. A first laser scanner is positioned along the first optical path and configured to rotate to redirect light and scan the sample with the mid-infrared beam. A second laser scanner is positioned along the second optical path and configured to rotate to redirect light and scan the sample with the probe light. The laser scanners each include at least one mirror driven to rotate such that the mid-infrared beam and the probe light scan the sample synchronously.Type: ApplicationFiled: August 15, 2023Publication date: February 15, 2024Applicant: Trustees of Boston UniversityInventors: Ji-Xin Cheng, Lu Lan, Jiaze Yin
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Publication number: 20240041848Abstract: Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.Type: ApplicationFiled: June 7, 2023Publication date: February 8, 2024Applicant: TRUSTEES OF BOSTON UNIVERSITYInventor: Douglas V. FALLER