Patents Assigned to Trustees of Boston University
  • Publication number: 20240053264
    Abstract: A mid-infrared photothermal microscopy system images a sample. A mid-infrared optical source generates a mid-infrared beam which is directed along a first optical path to reach the substrate on a first side and heat the sample. A probe light source generates a probe light which is directed along a second optical path to reach the substrate on a second side and illuminate the sample. A first laser scanner is positioned along the first optical path and configured to rotate to redirect light and scan the sample with the mid-infrared beam. A second laser scanner is positioned along the second optical path and configured to rotate to redirect light and scan the sample with the probe light. The laser scanners each include at least one mirror driven to rotate such that the mid-infrared beam and the probe light scan the sample synchronously.
    Type: Application
    Filed: August 15, 2023
    Publication date: February 15, 2024
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Lu Lan, Jiaze Yin
  • Publication number: 20240041848
    Abstract: Provided are methods and compositions for the prevention and/or treatment of viral conditions, virally-induced conditions and inflammatory conditions. The methods can comprise administering to a subject a viral inducing agent with an antiviral agent, and optionally an additional agent. The viral inducing agent can be a HDAC inhibitor administered orally.
    Type: Application
    Filed: June 7, 2023
    Publication date: February 8, 2024
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventor: Douglas V. FALLER
  • Publication number: 20240036339
    Abstract: An exemplary illumination source is provided. The illumination source includes a light integrating device for coupling to at least one optical structure at an output port. The light integrating device includes at least one input port. At least one light source produces at least one optical illumination coupled to the at least one input port. A light adjusting tool controls the optical illumination emitted by the light integrating device. The light adjusting tool controls uniformity of light emitted by the light integrating device by modifying at least one internal surface of the light integrating device.
    Type: Application
    Filed: July 26, 2023
    Publication date: February 1, 2024
    Applicant: Trustees of Boston University
    Inventors: M. Selim Ünlü, Mete Aslan, Iris Celebi, Celalettin Yurdakul, Allison Marie Marn
  • Publication number: 20240035979
    Abstract: Systems and methods implement of high-speed delay scanning for spectroscopic SRS imaging characterized by scanning a first pulsed beam across a stepwise reflective surface (such as a stepwise mirror or a reflective blazed grating) in a Littrow configuration to generate near continuous temporal delays relative to a second pulsed beam. Systems and methods also implement deep learning techniques for image restoration of spectroscopic SRS images using a trained encoder-decoder convolution neural network (CNN) which in some embodiments may be designed as a spatial-spectral residual net (SS-ResNet) characterized by two parallel filters including a first convolution filter on the spatial domain and a second convolution filter on the spectral domain.
    Type: Application
    Filed: August 17, 2023
    Publication date: February 1, 2024
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Haonan Lin
  • Patent number: 11883344
    Abstract: An example photoacoustic system for neurostimulation includes a light producing device for producing light of a specific wavelength. At least one nanotransducer is binded on a surface of a neuron. The nanotransducer converts the light with the specific wavelength into at least one acoustic wave at or near the neuron.
    Type: Grant
    Filed: January 30, 2023
    Date of Patent: January 30, 2024
    Assignee: Trustees of Boston University
    Inventors: Chen Yang, Ji-Xin Cheng
  • Patent number: 11883246
    Abstract: The inventions provided herein relate to tissue markers and uses thereof, e.g., to mark a target tissue site (e.g., a biopsy site in a breast tissue) or to produce a cell scaffold. The tissue markers described herein are designed to be resistant to fast migration (e.g., immediate migration after implantation through a needle track) and slow migration (e.g., over an extended period of time) upon implantation at a target tissue site (e.g., a biopsy site in a breast tissue), without using an adhesive. Additionally or alternatively, the tissue markers described herein can be readily detectable by at least one imaging modality, e.g., but not limited to magnetic resonance imaging, X-ray imaging, ultrasound imaging, or a combination thereof.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: January 30, 2024
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, BOSTON MEDICAL CENTER CORPORATION
    Inventors: Mark W. Grinstaff, Boris Nicolas Bloch, Jonah Kaplan
  • Patent number: 11884653
    Abstract: Ebola virus and Marburg virus are filoviruses and are responsible for outbreaks that cause up to 90% fatality, including the recent outbreak in West Africa that has resulted in over 11,000 deaths. The present disclosure generally relates to series novel arylnaphthalene compounds, having a formula (I) or a pharmaceutically acceptable salt thereof, as a vacuolar-ATPase inhibitor that are useful for the treatment for a broad spectrum of viral infections, including those infections caused by filoviruses. Pharmaceutical composition matters and methods of use are within the scope of this invention.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: January 30, 2024
    Assignees: Purdue Research Foundation, Trustees of Boston University
    Inventors: Vincent Jo Davisson, Aaron Raymond Lindstrom, Naoaki Fujii, Robert A. Davey
  • Publication number: 20240027655
    Abstract: An exemplary imaging system is provided. The imaging system includes a light source configured to illuminate a plurality of spatially separated regions of a material structure producing a first illumination. A lens produces an image of the spatially separated regions. A lens array magnifies the spatially separated regions of the image. The lens array produces a mosaic image comprised of magnified subimages of each region spatially separated region. A camera sensor to record the image.
    Type: Application
    Filed: July 18, 2023
    Publication date: January 25, 2024
    Applicants: Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: Thomas Bifano, Jerome Mertz, Marshall Ma, Devin Beaulieu
  • Publication number: 20240024505
    Abstract: The disclosure relates generally to methods and compositions for generation or enhancement of partial or complete cellular signaling pathways
    Type: Application
    Filed: July 12, 2023
    Publication date: January 25, 2024
    Applicant: Trustees of Boston University
    Inventors: Mark W. Grinstaff, Jack R. Kirsch, Amanda K. Williamson, Brett Tingley
  • Patent number: 11878057
    Abstract: Provided herein are lipid A molecules engineered from Moritella lipopolysaccharides and uses thereof.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: January 23, 2024
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, THE CHILDREN'S MEDCIAL CENTER CORPORATION, MINISTRY OF FISHERIES AND MARINE RESOURCES DEVELOPMENT
    Inventors: Randi Dawn Rotjan, Anna Gauthier, Aranteiti Tekiau, Jonathan C. Kagan
  • Publication number: 20240019369
    Abstract: An example microscope includes a pump laser for providing a first illumination to a sample. A laser array provides a second illumination to the sample. The laser array may include a plurality of laser elements, each providing oblique illuminations to the sample. An illumination collecting source collects the first illumination and the second illumination from the sample. The illumination collecting source may capture transient 3D refractive index (RI) variations in the sample due to the first illumination and second illumination.
    Type: Application
    Filed: January 23, 2023
    Publication date: January 18, 2024
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Jian Zhao, Lei Tian, Alex Matlock
  • Patent number: 11874343
    Abstract: A gradiometer includes a at least one magnet attached to a beam. The magnet moves in response to a magnetic force. A sensing element is configured to measure movement or deflection of the beam or magnet. The gradiometer is configured to determine a gradient of a magnetic field acting on the first magnet based on movement of the magnet. The gradiometer can further measure higher order gradients.
    Type: Grant
    Filed: February 21, 2023
    Date of Patent: January 16, 2024
    Assignee: Trustees of Boston University
    Inventors: Joshua Javor, David Bishop, David Campbell, Matthias Imboden
  • Publication number: 20240011990
    Abstract: The systems, methods, devices and kits disclosed herein be used to determine the presence and/or level a target analyte(s) in a biological sample, wherein the analyte(s) is associated with a pathogenic (e.g., a viral antigen or whole virus) or otherwise altered physiological condition (e.g., pregnancy). In certain embodiments, the systems, methods, devices and kits provide one or more improved properties relative to the RT-PCT and lateral flow antibody assays known in the art for the detection of SARS-CoV-2, including but not limited to, assay time, ease of use, risk of infection, accuracy, specificity, selectivity, limit of detection of the assay, quantitative detection and the effect of common interferents to the sensor output, cost, simplicity or a combination thereof.
    Type: Application
    Filed: July 16, 2021
    Publication date: January 11, 2024
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Karthika SANKAR, Scott SCHAUS, James GALAGAN, Catherine KLAPPERICH, John CONNOR, Mark GRINSTAFF, Keith HEARON
  • Patent number: 11870459
    Abstract: Described is a decoder suitable for use with any communication or storage system. The described decoder has a modular decoder hardware architecture capable of implementing a noise guessing process and due to its dependency only on noise, the decoder design is independent of any encoder, thus making it a universal decoder. Hence, the decoder architecture described herein is agnostic to any coding scheme.
    Type: Grant
    Filed: April 8, 2021
    Date of Patent: January 9, 2024
    Assignees: Massachusetts Institute of Technology, National University of Ireland Maynooth, Trustees of Boston University
    Inventors: Amit Solomon, Muriel Medard, Kenneth R. Duffy, Rabia Tugce Yazicigil Kirby, Vaibhav Bansal, Wei An
  • Publication number: 20230408376
    Abstract: Provided herein are systems for determining a stretch condition of a tissue and assessing the stiffness of the tissue. Also provided herein are methods for using the systems for measuring stiffness of a tissue, assessing the effect of an agent on a tissue, and identifying subjects having a disease or disorder associated with increased or decreased stiffness of a tissue.
    Type: Application
    Filed: June 16, 2023
    Publication date: December 21, 2023
    Applicants: Trustees of Boston University, Beth Israel Deaconess Medical Center, Inc.
    Inventors: Bela Suki, Jae Hun Kim, Joseph Hall, Ramaswamy Krishnan, Niccole Schaible
  • Publication number: 20230408805
    Abstract: Microscopic analysis of a sample includes a system using dark-field illumination. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. A visible light source generates a light illuminating the sample on a substrate and creating a scattered field and a reflected field along a collection path of the system. A pupil mask is positioned along the collection path to block the reflected field while allowing the scattered field to pass therethrough. A camera is positioned at an end of the collection path to collect the scattered field and generate a dark-field image of the sample.
    Type: Application
    Filed: June 2, 2023
    Publication date: December 21, 2023
    Applicant: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Celalettin Yurdakul, Haonan Zong, M. Selim Ünlü
  • Patent number: 11846217
    Abstract: A bilayler metamaterial silencer allows substantial fluid through the apparatus, while mitigating the propagation of sound through the apparatus, and while providing a form factor that is significantly more compact than previously-known devices. Moreover, illustrative embodiments allow a designer to specify one or both of the frequency or frequencies at which the apparatus mitigates sound propagation, and/or the bandwidth around the frequency or frequencies at which the apparatus mitigates sound propagation.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: December 19, 2023
    Assignee: Trustees of Boston University
    Inventors: Xin Zhang, Reza Ghaffarivardavagh, Stephan Anderson
  • Patent number: 11841265
    Abstract: A system for near-surface subsurface imaging for detecting and characterizing subsurface heterogeneities comprises a non-contact acoustic source that senses a plurality of acoustic waves that travel through a surface; an instrument that outputs probing electromagnetic signals through the surface that interact and are affected by scattered signals of the acoustic waves and further senses vibrational modes of a subsurface below the surface; an imaging device that dynamically generates a time sequence of images of properties of the acoustic waves and maps elastic wave fields of the acoustic waves; and a processor that analyzes dynamic multi-wave data of the images to quantify spatial variations in the mechanical and viscoelastic properties of the subsurface.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: December 12, 2023
    Assignees: The Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: Stephen Brown, Thomas Szabo, Daniel R. Burns, Michael Fehler
  • Publication number: 20230384288
    Abstract: Disclosed is an assay for determining resistance in a target cell or tissue to a therapy associated with cellular stress using chemical microscopy and high-throughput single cell analysis to determine functional metabolic alteration, including determining metabolic reprogramming in a target cell or tissue to a therapy associated with cellular stress, and methods of using the assays.
    Type: Application
    Filed: May 15, 2023
    Publication date: November 30, 2023
    Applicants: Trustees of Boston University, Northwestern University
    Inventors: Ji-Xin Cheng, Junjie Li, Yuying Tan, Daniela Matei, Guangyuan Zhao
  • Publication number: 20230381142
    Abstract: Provided herein are antileishmanial compounds, compositions comprising the antileishmanial compounds, and use thereof.
    Type: Application
    Filed: May 25, 2023
    Publication date: November 30, 2023
    Applicant: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Scott E. SCHAUS, Lauren E. BROWN, Mark W. GRINSTAFF, Danielle M. FITZGERALD, Diana L. DIAZ, John A. KAVOURIS, Jair LAGE DE SIQUEIRA-NETO, James MCKERROW, Camila INDIANI DE OLIVEIRA