Patents Assigned to Trustees of Boston University
  • Patent number: 11573177
    Abstract: Provided herein are methods for capturing extracellular vesicles from a biological sample for quantification and/or characterization (e.g., size and/or shape discrimination) using an SP-IRIS system. Also provided herein are methods of detecting a biomarker on captured extracellular vesicles or inside the captured vesicles (e.g., intra-vesicular or intra-exosomal biomarkers).
    Type: Grant
    Filed: January 14, 2021
    Date of Patent: February 7, 2023
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: M. Selim Ünlü, George G. Daaboul, Marcella Chiari
  • Patent number: 11572565
    Abstract: The technology described herein is directed to inducible and repressible polypeptides and polypeptide systems. In particular, described herein are split sequence-specific nucleases and split recombinases that are linked to drug-inducible or drug-repressible dimerization domains. In some embodiments, the polypeptides comprise sequestering domains and/or have their expression controlled by an inducible promoter. In multiple aspects described herein are polynucleotides, vectors, cells, and pharmaceutical compositions comprising said polypeptides or polypeptide systems. Also described herein are methods of using said polypeptide systems to modulate the expression of a target polypeptide or to treat a subject in need of a cell therapy.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: February 7, 2023
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Wilson Wai Chun Wong, Yage Ding
  • Patent number: 11564742
    Abstract: A system for neuromodulation includes a split-ring resonator (SRR) comprising a resonance circuit, the SRR being implantable in a cranial target site and a source of microwave signals, wherein the microwave signals are deliverable wirelessly to couple with the SRR to produce a localized electrical field, wherein the localized electrical field inhibits one or more neurons at the cranial target site with submillimeter spatial precision.
    Type: Grant
    Filed: May 5, 2022
    Date of Patent: January 31, 2023
    Assignee: Trustees of Boston University
    Inventors: Chen Yang, Ji-Xin Cheng, Nan Zheng, Yueming Li, Ying Jiang, Lu Lan, Carolyn Marar
  • Patent number: 11561221
    Abstract: Herein is described kinetic assay, in which individual binding events are detected and monitored during sample incubation. This method uses interferometric reflectance imaging to detect thousands of individual binding events across a multiplex solid phase sensor with a large area. A dynamic tracking procedure is used to measure the duration of each event. From this, the total rates of binding and de-binding as well as the distribution of binding event durations are determined. Systems and components for performing the kinetic assay are also described.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: January 24, 2023
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Derin Sevenler, M. Selim Ünlü
  • Patent number: 11561179
    Abstract: Microscopic analysis of a sample includes a fluorescent dye disposed within the sample. A mid-IR optical source generates a mid-infrared beam, which is directed onto the sample to induce a temperature change by absorption of the mid-infrared beam. An optical source generates a probe beam directed to impinge on the sample. A detector detects fluorescent emissions from the sample when the probe beam impinges on the sample. A data acquisition and processing system acquires and processes the detected fluorescent emissions from the sample to: (i) generate a signal indicative of infrared absorption by the sample, (ii) generate a signal indicative of temperature in the sample based on the signal indicative of infrared absorption by the sample, (iii) generate an image of the sample using the signal indicative of temperature in the sample.
    Type: Grant
    Filed: September 3, 2021
    Date of Patent: January 24, 2023
    Assignee: Trustees of Boston University
    Inventors: Ji-Xin Cheng, Yi Zhang, Cheng Zong
  • Publication number: 20230017023
    Abstract: A ring resonator optical modulator comprises: an optical region in which optical radiation can propagate in a circular path having an inner radius and an outer radius coincident with an outer perimeter of the ring resonator optical modulator; a MOS capacitor structure having an upper gate device layer and a lower body device layer, and an insulating material being disposed between the upper gate device layer and the lower body device layer; and a cladding region. The optical radiation is confined within the optical region. The insulating material has a first region disposed in the optical region having a first thickness and a second region having a second thickness greater than the first thickness, the second region being disposed radially inwardly from the inner radius of the optical region, such that the optical radiation is radially confined toward the outer side of the inner radius of the optical region.
    Type: Application
    Filed: September 26, 2022
    Publication date: January 19, 2023
    Applicant: Trustees of Boston University
    Inventors: Hayk Gevorgyan, Milos Popovic
  • Patent number: 11550003
    Abstract: A sensing system, and method of operating same, can act as a highly sensitive gradiometer. A first non-magnetic element, such as a sphere, is driven at a first resonance frequency along an axis. A magnet is attached to a second non-magnetic element, such as a plate, and driven at a second resonance frequency along the axis. The first non-magnetic element and the second non-magnetic element are coupled by a force along the axis, in resonance. The gradiometer is configured to determine a gradient magnetic field acting on one or more of the first non-magnetic element and magnet based on change in at least one resonance characteristic.
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: January 10, 2023
    Assignee: Trustees of Boston University
    Inventors: David J. Bishop, Joshua Javor, David K. Campbell, Matthias Imboden
  • Patent number: 11542240
    Abstract: Provided herein are compositions and methods for the treatment and prevention of cancer, including melanoma.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: January 3, 2023
    Assignees: TRUSTEES OF BOSTON UNIVERSITY, XIAMEN UNIVERSITY
    Inventors: Rutao Cui, Chengqian Yin, Xianming Deng, Ting Zhang
  • Patent number: 11536685
    Abstract: Described herein are systems, assays, methods and compositions for identification of oxidase microbial redox-enzymes (MREs) specific to an analyte of interest from an environmental source. The technology relates to identification of analyte-responsive MREs that can quantify the concentration of a target analyte with high specificity and high sensitivity, for example, where the identified analyte-responsive redox-enzyme can be used to engineer an electrochemical biosensor.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: December 27, 2022
    Assignee: Trustees of Boston University
    Inventors: James Galagan, Uros Kuzmanovic, Luis Ortiz, Douglas Densmore, Nicolas Shijie Shu
  • Patent number: 11530252
    Abstract: Described herein is a chimeric antigen receptor (CAR) platform with the ability to (a) serve as an ON/OFF switch (with the ability for tenability/titrability), (b) sense multiple antigens and perform logic computations, and/or (c) independently regulate multiple signaling pathways. The compositions provided herein permit the degree of control and discrimination necessary to optimize CAR T cell therapy. Also described herein are cells comprising such compositions and the use of these compositions and/or cells in the treatment of cancer.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: December 20, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Wilson W. Wong, Jang Hwan Cho
  • Patent number: 11530246
    Abstract: The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.
    Type: Grant
    Filed: May 15, 2020
    Date of Patent: December 20, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Ahmad S. Khalil, Wilson Wai Chun Wong, Divya Israni, Huishan Li
  • Publication number: 20220387432
    Abstract: The present invention provides methods and compositions for treatment of prion disease.
    Type: Application
    Filed: September 18, 2020
    Publication date: December 8, 2022
    Applicants: EIP Pharma, Inc., Trustees of Boston University
    Inventors: John Jahangir Alam, David A. Harris, Cheng Fang
  • Publication number: 20220378363
    Abstract: Transient molecules in the gastrointestinal (GI) tract, such as nitric oxide and hydrogen sulfide, are important signals and mediators of inflammatory bowel disease (IBD). Because these molecules may be short-lived in the body, they are difficult to detect. To track these reactive molecules in the GI tract, a miniaturized device has been developed that integrates genetically engineered probiotic biosensors with a custom-designed photodetector and readout chip. Leveraging the molecular specificity of living sensors, bacteria were genetically encoded to respond to IBD-associated molecules by luminescing. Low-power electronic readout circuits (e.g., using nanowatt power) integrated into the device convert the light from just 1 ?L of bacterial culture into a wireless signal. Biosensor monitoring was demonstrated in the GI tract of small and large animal models and integration of all components into a sub-1.4 cm3 ingestible form factor capable of supporting wireless communication.
    Type: Application
    Filed: April 26, 2022
    Publication date: December 1, 2022
    Applicants: Massachusetts Institute of Technology, Trustees of Boston University, The Brigham and Women's Hospital, Inc.
    Inventors: Timothy Kuan-Ta Lu, Rabia Tugce Yazicigil Kirby, Carlo Giovanni Traverso, Jenna Ahn, Maria Eugenia Inda, Miguel Jimenez, Qijun Liu, Phillip Nadeau, Christoph Winfried Johannes Steiger, Adam Wentworth
  • Publication number: 20220373537
    Abstract: Described herein are methods relating to the diagnosis, prognosis, and treatment of airway dysfunction, e.g., bronchiectasis by detecting gene expression in a sample obtained from a subject. Exemplary samples include a bronchial brushing, nasal brushing, sputum, or peripheral blood sample.
    Type: Application
    Filed: May 19, 2022
    Publication date: November 24, 2022
    Applicants: TRUSTEES OF BOSTON UNIVERSITY, THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Ke XU, Marc E. LENBURG, Ehab BILLATOS, Alejandro A. DIAZ
  • Patent number: 11506841
    Abstract: An optical fiber system exploits a principle of topological confinement for guided higher-order modes, in contrast to more conventional total-internal-reflection (TIR) confinement. The optical fiber has a geometry and index profile defining a cutoff wavelength for a predetermined L-mode of optical signal propagation in the optical fiber, where L is azimuthal mode index. An optical source subsystem is coupled to the optical fiber to establish an optical signal propagating in the optical fiber, wherein the optical signal has the predetermined L-mode and a wavelength being either (1) at least 15% above the cutoff wavelength such that the optical beam propagates as a topologically confined mode, or (2) sufficiently above the cutoff wavelength that, based on the L-mode of the optical beam, the optical beam propagates as a topologically confined mode having propagation loss less than 3 dB/meter.
    Type: Grant
    Filed: May 9, 2021
    Date of Patent: November 22, 2022
    Assignee: Trustees of Boston University
    Inventors: Siddharth Ramachandran, Zelin Ma
  • Patent number: 11504338
    Abstract: Embodiments disclosed herein relates to ganglioside GM3-containing mixed lipids nanoparticles having an overall size between 60-100 nm, the making thereof and the uses. The nanoparticles selectively targeted to CD169+ expressing cells such as dendritic cells and macrophage. The nanoparticles are endocytosed by the CD169+ expressing cells.
    Type: Grant
    Filed: April 9, 2020
    Date of Patent: November 22, 2022
    Assignee: TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Bjoern Markus Reinhard, Suryaram Gummuluru
  • Patent number: 11505584
    Abstract: Embodiments of the disclosure provide a method for treatment of damaged lung tissue, e.g., lungs of a patient with a viral infection (e.g., coronavirus) and/or a bacterial infection and/or a parasitic pathogen or a patient whose lung tissue was damaged by exposure to a chemical, and a patient with acute respiratory distress syndrome (ARDS). Also provided is a method for protecting the brain from neuro-invasion and preventing inflammatory damage to organs remote from the lungs, by blocking cytokine synthesis in the lungs. The treatment includes administering a leptin antagonist (LepA) locally to the upper airways and/or to the lungs of the patient. Typically, the LepA is administered in an inhalable composition, such as, an aerosol.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: November 22, 2022
    Assignees: REMODELESS CV LTD, TRUSTEES OF BOSTON UNIVERSITY
    Inventors: Jacob Schneiderman, Florian Douam
  • Publication number: 20220361782
    Abstract: Disclosed is a hormone electrochemical biosensor, e.g. an amperometric biosensor, for the detection of a hormone and measurement of the concentration of a hormone. The disclosed hormone biosensor comprises a hormone-catalyzing enzyme, such as KSDH1. Also described herein are systems comprising an amperometric biosensor, e.g., chronoamperometric biosensor and methods of using the chronoamperometric biosensor.
    Type: Application
    Filed: April 30, 2022
    Publication date: November 17, 2022
    Applicant: Trustees of Boston University
    Inventors: James Galagan, Uros Kuzmanovic
  • Publication number: 20220362094
    Abstract: In at least some aspects, the present concepts include a method for configuring an assistive flexible suit including the acts of outfitting a person with an assistive flexible suit, monitoring an output of at least one sensor of the assistive flexible suit as the person moves in a first controlled movement environment, identifying at least one predefined gait event using the output of the at least one sensor, adjusting an actuation profile of the at least one actuator and continuing to perform the acts of monitoring, identifying and adjusting until an actuation profile of the at least one actuator generates a beneficial moment about the at least one joint to promote an improvement in gait. The at least one controller is then set to implement the actuation profile.
    Type: Application
    Filed: April 4, 2022
    Publication date: November 17, 2022
    Applicants: Trustees of Boston University, President and Fellows of Harvard College
    Inventors: Stefano Marco Maria De Rossi, Kathleen E. O'Donnell, Jaehyun Bae, Alan Thomas Asbeck, Kenneth G. Holt, Conor J. Walsh
  • Patent number: 11502220
    Abstract: Semiconductor structures involving multiple quantum wells provide increased efficiency of UV and visible light emitting diodes (LEDs) and other emitter devices, particularly at high driving current. LEDs made with the new designs have reduced efficiency droop under high current injection and increased overall external quantum efficiency. The active region of the devices includes separation layers configured between the well layers, the one or more separation regions being configured to have a first mode to act as one or more barrier regions separating a plurality of carriers in a quantum confined mode in each of the quantum wells being provided on each side of the one or more separation layers and a second mode to cause spreading of the plurality of carriers across each of the quantum wells to increase an overlap integral of all of the plurality of carriers. The devices and methods of the invention provide improved efficiency for solid state lighting, including high efficiency ultraviolet LEDs.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: November 15, 2022
    Assignee: Trustees of Boston University
    Inventors: Yitao Liao, Theodore D. Moustakas