Patents Assigned to Trustees of Columbia University
  • Compositions and methods for using engineered deubiquitinases for probing ubiquitin-dependent cellular processes
    Patent number: 12091695
    Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.
    Type: Grant
    Filed: November 3, 2023
    Date of Patent: September 17, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Henry M. Colecraft, Scott Kanner
  • Compositions and methods for using engineered deubiquitinases for probing ubiquitin-dependent cellular processes
    Patent number: 12084696
    Abstract: The present disclosure provides, inter alia, a recombinant engineered deubiquitinase (DUB) and methods for treating or ameliorating an inherited ion channelopathy, such as long QT syndrome, Brugada syndrome, or cystic fibrosis, in a subject. Further provided are methods for screening mutations causing such inherited ion channelopathies for a trafficking-deficient mutation that is treatable by the recombinant engineered DUB disclosed herein.
    Type: Grant
    Filed: November 3, 2023
    Date of Patent: September 10, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Henry M. Colecraft, Scott Kanner
  • Programmable Nanoencapsulation for Delivery of Probiotics in Vivo
    Publication number: 20240293474
    Abstract: Programmable bacterial cells that comprise a gene that regulates capsular polysaccharide nanoencapsulation of the bacterium linked to an exogenous promoter, wherein expression of the gene and the nanoencapsulation can be programmed or controlled by an external modulator of the exogenous promoter and related compositions and methods.
    Type: Application
    Filed: October 31, 2023
    Publication date: September 5, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Tal DANINO, Kam LEONG, Tetsuhiro HARIMOTO, Jaeseung HAHN
  • Systems, devices, and methods for harmonization of imaging datasets including biomarkers
    Patent number: 12079960
    Abstract: An exemplary system, method and computer-accessible medium for harmonizing neuromelanin (NM) data using combat directly on a NM database or using combat generated coefficients to harmonize future data can include, for example, receiving imaging information of a brain of the patient(s), from one MRI scanner, receiving imaging information of a brain of the patient(s), from a second MRI scanner and using combat to harmonize the data between scanners against a reference dataset. The Neuromelanin (NM) concentration of the patient(s) can then be determined based on the harmonized data. The NM concentration can be determined using a voxel-wise analysis procedure. The voxel-wise analysis procedure can be used to determine a topographical pattern(s) within a substantia nigra (SN) of the brain of the patient(s).
    Type: Grant
    Filed: March 11, 2022
    Date of Patent: September 3, 2024
    Assignees: Terran Biosciences Inc., The Trustees of Columbia University in the City of New York, The Research Foundation for Mental Hygiene, Inc.
    Inventors: Samuel Clark, Kenneth Wengler, Guillermo Horga Hernandez
  • Systems, methods, and media for proving the correctness of software on relaxed memory hardware
    Patent number: 12079102
    Abstract: Mechanisms for proving the correctness of software on relaxed memory hardware are provided, the mechanisms comprising: receiving a specification, a hardware model, and an implementation for the software to be executed on the relaxed memory hardware; evaluating the software using a sequentially consistent hardware model; evaluating the software using a relaxed memory hardware model and at least one of the following conditions: a data-race-free (DRF)-kernel condition; a no-barrier-misuse condition; a memory-isolation condition; a transactional-page-table condition; a write-once-kernel-mapping condition; and a weak-memory-isolation condition; and outputting an indication of whether the software is correct based on the evaluating the software using the sequentially consistent hardware model and the evaluating the software using the relaxed memory hardware model.
    Type: Grant
    Filed: July 14, 2021
    Date of Patent: September 3, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Ronghui Gu, Jason Nieh, Runzhou Tao
  • Methods, systems, and media for testing insider threat detection systems
    Patent number: 12079345
    Abstract: Methods, systems, and media for testing insider threat detection systems are provided.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: September 3, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Salvatore J. Stolfo, Preetam Kumar Dutta
  • 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE
    Publication number: 20240287092
    Abstract: The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is H, OH, or halogen; B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole, wherein the heterobicycle is other than chloro substituted indole; and the pyrazole, when substituted, is substituted with other than trifluoromethyl, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 9, 2024
    Publication date: August 29, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Konstantin Petrukhin, Christopher Cioffi, Graham Johnson, Nicoleta Dobri, Emily Freeman, Ping Chen, Michael Conlon, Lei Zhu
  • System, method, computer-accessible and apparatus for providing near-infrared spectroscopy for anatomical mapping of the epicardium
    Patent number: 12072283
    Abstract: An exemplary catheter can be provided, which can include, for example a source fiber(s) configured to (i) receive a near infrared spectroscopic (NIRS) radiation, and (ii) provide the NIRS radiation to a portion(s) of a sample(s), a detection fiber(s) configured to receive a return radiation from the sample(s) that can be based on the NIRS radiation that was provided to the portion(s) of the sample(s), and an ablation electrode(s) configured to ablate the sample(s) based on the return radiation. The source fiber(s), the detection fiber(s), and the ablation electrode(s) can be integrated into the single sheath. The ablation electrode(s) can be a radiofrequency ablation electrode.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: August 27, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Christine Hendon, Rajinder Singh-Moon, James McLean, Soo Young Park
  • Compositions and methods for the treatment and prevention of vascular malformations
    Patent number: 12070468
    Abstract: Provided herein are methods and compositions for treating and preventing vascular malformations including lymphatic, venous, capillary, arteriovenous, and combinations thereof. Methods of treatment and prevention include the administration of proteasome inhibitors, omipalisib, disulfiram, and agents which target genes in the PI3K/AKT/mTOR or RAS/RAF/MAPK pathways, including but not limited to Pik3ca, Pik3r3, Tsc2, Rasa1, Map2k2, and Glmn.
    Type: Grant
    Filed: November 10, 2022
    Date of Patent: August 27, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Carrie J. Shawber, June K. Wu, Ajit Muley
  • SYSTEMS AND METHODS FOR BIOREMEDIATION OF PER- AND POLYFLUOROALKYL SUBSTANCES AND 1,4-DIOXANE
    Publication number: 20240279098
    Abstract: Systems and methods for performing bioremediation using the Geobacillus sp. bacterial strain are provided which are capable of effectively degrading 1,4-dioxane and/or per- and polyfluoroalkyl substances (PFAS) and/or BaP and efficiently degrading other ring-based organic contaminants. The exemplary bioremediation methods include steps for administering an effective, degrading amount of the bacteria to soil containing excess amounts of 1,4-dioxane and/or PFAS and/or BaP and incubating the bacteria administered to the soil at a given temperature and for a duration that are suitable for promoting incubation and reducing and the concentration of 1,4-dioxane and/or PFAS and/or BaP below a maximum concentration, as might be specified by a regulatory body.
    Type: Application
    Filed: April 19, 2024
    Publication date: August 22, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventor: Raymond SAMBROTTO
  • Powered walking assistant and associated systems and methods
    Patent number: 12064390
    Abstract: A robotic assistant provides active support for disabled users and may take the approximate form of a cane or a walker.
    Type: Grant
    Filed: April 30, 2020
    Date of Patent: August 20, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Sunil K. Agrawal, Danielle Stramel, Robert M. Carrera
  • Optical super-multiplexing by polyynes
    Patent number: 12065692
    Abstract: A method for optical super-multiplexing using polyynes to provide enhanced images from stimulated Raman microscopy is disclosed. In some exemplary embodiments, the polyynes are organelle-targeted or spectral barcoded. Imaging can be enhanced by using the polyynes to image whole live cells or specific organelles within live cells. The polyynes can also be used in optical data storage (i.e., encoding) and identification (i.e., decoding) applications.
    Type: Grant
    Filed: August 3, 2018
    Date of Patent: August 20, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Wei Min, Fanghao Hu
  • Magnetic resonance imager with coils for arbitrary image space and fabrication thereof
    Patent number: 12061248
    Abstract: An apparatus for fabricating non-planar coils includes a rotating table driven by a first motor; a wire approach height adjustment arm driven by a second motor; and a synchronization module configured such that a wire traversing from the height adjustment arm to a bobbin on the rotating table passes into a non-planar groove cut in the bobbin without damaging the wire. Performing magnetic resonance (MR) measurements includes a plurality of coil units configured for generating a gradient or shim magnetic field. The coil unit includes a plurality of coil windings, and each coil winding is separated longitudinally from an adjacent coil winding. A single pair of electrically conducting leads is configured to cause current to flow through all of the plurality of coil windings in the coil unit. Techniques include methods to fabricate and operate the apparatus.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: August 13, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Christoph Juchem, Michael Sebastian Theilenberg, Yun Shang, Jalal Ghazouani
  • System, method and computer-accessible medium for use of heavy water as a probe for imaging metabolic activities
    Patent number: 12062422
    Abstract: Incorporation of deuterium into the lipids, proteins, and/or genetic material in cells, tissues, organs, or organisms, including animals, such as humans, and plants, by administration of heavy water, allows for the spectral determination of levels of lipids, proteins, and/or genetic material using Raman spectroscopy, such as stimulated Raman spectroscopy. Following administration of a drug, changes in the relative amounts of lipid, protein, and/or genetic materials can be determined, and the efficacy, or lack thereof, of the administered drug can be determined.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: August 13, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Wei Min, Lingyan Shi
  • Catalyst compositions including metal chalcogenides, processes for forming the catalyst compositions, and uses thereof
    Patent number: 12053769
    Abstract: Aspects of the present disclosure generally relate to catalyst compositions including metal chalcogenides, processes for producing such catalyst compositions, processes for enhancing catalytic active sites in such catalyst compositions, and uses of such catalyst compositions in, e.g., processes for producing conversion products. In an aspect, a process for forming a catalyst composition is provided. The process includes introducing an electrolyte material and an amphiphile material to a metal chalcogenide to form the catalyst composition. In another aspect, a catalyst composition is provided. The catalyst composition includes a metal chalcogenide, an electrolyte material, and an amphiphile material. Devices for hydrogen evolution reaction are also provided.
    Type: Grant
    Filed: December 21, 2022
    Date of Patent: August 6, 2024
    Assignees: Honda Motor Co., Ltd., The Trustees of Columbia University in the City of New York
    Inventors: Xufan Li, Avetik Harutyunyan, Xiangye Liu, Baiching Li, James Curtis Hone, Daniel V. Esposito
  • Fluid responsive devices and methods
    Patent number: 12053616
    Abstract: Aspects provide fluid responsive actuators and methods of using fluid responsive actuators capable of generating a power-to-volume ratio sufficient to inject a drug from a syringe within an injection period from about 1 to about 60 seconds after exposure of the fluid responsive elements to a fluid. The fluid responsive actuators can be used to inject viscous drugs to a patient.
    Type: Grant
    Filed: October 20, 2020
    Date of Patent: August 6, 2024
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Ozgur Sahin
  • Substituted benzo[f]imidazo[1,5-a][1,4]diazepines as GABA(a) receptor modulators
    Patent number: 12054491
    Abstract: The present invention describes substituted benzo[f]imidazo[1,5-a][1,4]diazepines of the formula (I): wherein R1, R2, R2?, R3, and X are as disclosed herein. These compounds target alpha-4 and alpha-5 GABAa receptors and are useful for the treatment of airway hyperresponsiveness and inflammation in asthma.
    Type: Grant
    Filed: August 11, 2022
    Date of Patent: August 6, 2024
    Assignees: UWM Research Foundation, Inc., The Trustees of Columbia University in the City of New York
    Inventors: Alexander E. Arnold, Douglas C. Stafford, James M. Cook, Charles W. Emala, Gloria Forkuo, Rajwana Jahan, Revathi Kodali, Guanguan Li, Michael Rajesh Stephen
  • METHODS OF TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE INCLUDING COMPOUNDS USEFUL THEREIN
    Publication number: 20240254077
    Abstract: The present invention relates to the treatment of chronic obstructive pulmonary disease (COPD). More specifically, embodiments of the invention provide a pharmaceutical carrier and a compound that inhibit the induction of MMP-1 expression by cigarette smoke.
    Type: Application
    Filed: March 5, 2024
    Publication date: August 1, 2024
    Applicant: The Trustees of Columbia University in the City of New York
    Inventor: Jeanine D'Armiento
  • ISOMEROHYDROLASE INHIBITOR FOR TREATMENT OF ATROPHIC FORM OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE
    Publication number: 20240245647
    Abstract: The present disclosure provides a compound having the structure:
    Type: Application
    Filed: December 18, 2023
    Publication date: July 25, 2024
    Applicants: The Trustees of Columbia University in the City of New York, Albany College of Pharmacy and Health Sciences in the City of Albany, The Board of Regents of the University of Oklahoma
    Inventors: Konstantin Petrukhin, Christopher L. Cioffi, Yuhong Wang, Jian-xing Ma, Gennadiy Moiseyev
  • 10E8 neutralizing antibody variants that bind to the MPER region of HIV-1 GP41 and their use
    Patent number: 12043660
    Abstract: Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: July 23, 2024
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, The Trustees of Columbia University in the City of New York
    Inventors: Peter Kwong, Young Do Kwon, Ivelin Georgiev, Gilad Ofek, Baoshan Zhang, Krisha McKee, John Mascola, Mark Connors, Gwo-Yu Chuang, Sijy O'Dell, Robert Bailer, Mark Louder, Mangaiarkarasi Asokan, Richard Schwartz, Jonathan Cooper, Kevin Carlton, Michael Bender, Amarendra Pegu, Lawrence Shapiro, Tatyana Gindin, Lisa Kueltzo