Patents Assigned to Trustees of Darthmouth College
  • Peptides selective for Bcl-2 family proteins
    Patent number: 11286299
    Abstract: Provided herein are peptides selective for combinations of Mcl-1/Bfl-1/Bcl-xL. Also provided are compositions containing these polypeptides and methods of using such peptides in the treatment of cancer that include administering to a subject one of the polypeptides.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: March 29, 2022
    Assignees: Massachusetts Institute of Technology, Trustees of Darthmouth College
    Inventors: Vincent Xue, Justin Michael Jenson, Amy E. Keating, Jianfu Zhou, Gevorg Grigoryan
  • Methods of inhibiting IgE responses to thymus-dependent antigens with the anti-gp39 antibody MR1
    Patent number: 7476385
    Abstract: Methods of suppressing a humoral immune response to a thymus-dependent (TD) antigen are disclosed. The methods involve administering to a subject a TD antigen with an antagonist of a molecule which mediates contact-dependent helper effector functions. In a preferred embodiment, the antagonist is an antagonist of gp39. Primary and secondary humoral immune responses can be suppressed and suppression is prolonged.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: January 13, 2009
    Assignee: Trustees of Darthmouth College
    Inventors: Randolph J. Noelle, Teresa M. Foy