Abstract: Disclosed herein are autonomous molecular circuits that can function in cells. The circuits can process logical operations in which one or more input cues are among the operands and produce an appropriate output. Such circuits can be implemented in living cells, e.g., eukaryotic or prokaryotic cells that have been modified to include circuit components. The molecular circuits and cells containing the circuits can be used in a variety of applications including, e.g., diagnostics, therapeutics, and protein production.
Type:
Application
Filed:
October 23, 2009
Publication date:
August 5, 2010
Applicants:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE, TRUSTEES OF PRINCETON UNIVERSITY, Office of Technology Licensing and Intellectual Property
Inventors:
Yaakov Benenson, Ron Weiss, Leonidas Bleris, Zhen Xie