Patents Assigned to Trustees of the Univ. of Penna.
  • Method of treating inflammatory bowel disease with tributyrin
    Patent number: 5569680
    Abstract: A method for treating inflammatory bowel disease in a patient by inhibiting the production of interleukin-8 in intestinal epithelial cells by administering to said patient an enema of an effective amount of tributyrin.
    Type: Grant
    Filed: February 13, 1995
    Date of Patent: October 29, 1996
    Assignee: Trustees of the Univ. of Penna
    Inventor: Gary D. Wu
  • Method of identifying and modulating the activity of label retaining cells in hair follicles for diagnostic and therapeutic purposes
    Patent number: 5340744
    Abstract: Methods of detecting label retaining cells in self-renewing tissues, such as hair follicle, are provided. Methods of modulating the activity of slow-cycling cells and methods of evaluating the efficacy of agents for modulating the activity of stem cell populations are also provided. Generally, cells are continuously labeled, induced into a proliferative phase by exposure to an agent such as TPA or a cytokine, and then observed in relation to established criteria.
    Type: Grant
    Filed: October 12, 1993
    Date of Patent: August 23, 1994
    Assignees: Trustees of the Univ. of Penna., Trustees of the Univ. of New York
    Inventors: Robert M. Lavker, Tung-Tien Sun, George Cotsarelis
  • Propargylic and allenic sulfones
    Patent number: 5237101
    Abstract: Propargylic and allenic sulfones are disclosed having the ability to selectively cleave nucleic acids, especially deoxyribonucleic acid. Such compositions are capable of being synthetically modified to effect cleavage at selected, sequenced sites on nucleic acids.
    Type: Grant
    Filed: January 26, 1990
    Date of Patent: August 17, 1993
    Assignee: The Trustees of the Univ. of Penna.
    Inventors: K. C. Nicolaou, Guido Zaccarello, Golfo Skokotas, Peter Maligres
  • Affinity chromatogry using dried calcium alginate-magnetite separation media in a magnetically stabilized fluidized bed
    Patent number: 5167812
    Abstract: Disclosed is a method of conducting affinity chromatographic separations of biomaterials which comprises contacting the biomaterial with a solid support comprising a generally spherical bead having a generally central magnetic core and a surrounding exterior coat about the core comprising a material capable of binding with the biomaterial.
    Type: Grant
    Filed: January 17, 1992
    Date of Patent: December 1, 1992
    Assignee: Trustees of the Univ. of Penna.
    Inventors: David J. Graves, Mark A. Burns
  • General purpose neural computer
    Patent number: 5155802
    Abstract: A general purpose programmable neural computer which parallel processes analog data. The neural computer comprises neural elements for outputting an analog signal in response to at least one input signal, synaptic circuits interfaced with the neural elements for modifying gains of the neural elements, and switching circuits interfaced with the synaptic circuits and the neural circuits for routing signals between the synapse circuits and the neural circuits and for modifying the synaptic time constants, thereby changing connection architecture of the general purpose analog computer as desired. In this manner, the neural computer of the invention can be programmed to learn different confirurations as well as different synaptic values.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: October 13, 1992
    Assignee: Trustees of the Univ. of Penna.
    Inventors: Paul H. Mueller, Jan Van Der Spiegel