Patents Assigned to Trustees of Univ. of Penn
  • Method of identifying and modulating the activity of label retaining cells in hair follicles for diagnostic and therapeutic purposes
    Patent number: 5279969
    Abstract: Methods of detecting label retaining cells in self-renewing tissues, such as hair follicle, are provided. Methods of modulating the activity of slow-cycling cells and methods of evaluating the efficacy of agents for modulating the activity of stem cell populations are also provided. Generally, cells are continuously labeled, induced into a proliferative phase by exposure to an agent such as TPA or a cytokine, and then observed in relation to established criteria.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: January 18, 1994
    Assignees: Trustees of Univ. of Penn, New York Univ.
    Inventors: Robert M. Lavker, Tung-Tien Sun, George Cotsarelis