Patents Assigned to Trustees of University of Arkansas
  • Apparatus and method for providing low-loss transmission lines in interconnected mesh plane systems
    Publication number: 20030222288
    Abstract: An interconnected mesh plane system includes at least a pair of adjacent metal layers separated by dielectric, each layer having a plurality of spaced power, ground, and signal conductors extending in the same direction, with the conductors of one layer of the pair transverse to the conductors of the other layer, and with conductors of one layer connected to corresponding conductors of the other layer. The width of at least one signal conductor is increased to reduce signal loss, and the width of spaces between such a signal conductor and adjacent power and/or ground conductors is increased to provide a predetermined desired characteristic impedance of a transmission line that includes such a signal conductor.
    Type: Application
    Filed: May 29, 2002
    Publication date: December 4, 2003
    Applicant: The Board of Trustees for the University of Arkansas
    Inventor: Leonard W. Schaper
  • Composite allograft press
    Patent number: 6652260
    Abstract: A press to form a composite acetabular allograft cup for use in hip replacement surgery is disclosed. The acetabular cup formed by the press comprises bone cement and cancellous bone chips. The press includes a two-piece mold for forming the acetabular cup. The mold is removable from the press and may be available in many different sizes to accommodate a range of patients. A screw-type compression means is utilized to force the acetabular cup into the desired shape. A compression gauge allows the operator to monitor the pressure applied as the acetabular cup is formed to prevent excessive crushing of cancellous bone chips. Breaking jaws are used to separate the acetabular cup from the upper portion of the mold after the bone cement has set and the acetabular cup is formed.
    Type: Grant
    Filed: June 12, 2001
    Date of Patent: November 25, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Carl Nelson, J. Marcus Hollis, Charlene Flahiff
  • TADG-15: an extracellular serine protease overexpressed in carcinomas
    Patent number: 6649741
    Abstract: The present invention provides DNA encoding a TADG-15 protein as well as a TADG-15 protein. Also provided is a vector capable of expressing the DNA of the present invention adapted for expression in a recombinant cell and regulatory elements necessary for expression of the DNA in the cell. The present invention further provides for methods of inhibiting TADG-15 expression and/or protease activity methods of detecting TADG-15 mRNA and/or protein and methods of screening for TADG-15 inhibitors. Additionally, the present invention provides for cell-specific targeting via TADG-15 and methods of vaccinating an individual against TADG-15. The methods described are useful in the diagnosis. treatment and prevention of cancer particularly breast and ovarian cancer.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: November 18, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Hirotoshi Tanimoto
  • Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
    Publication number: 20030207316
    Abstract: The present invention provides a TADG-12 protein and a DNA fragment encoding such protein. Also provided is a vector/host cell capable of expressing the DNA. The present invention further provides various methods of early detection of associated ovarian and other malignancies, and of interactive therapies for cancer treatment by utilizing the DNA and/or protein disclosed herein.
    Type: Application
    Filed: June 5, 2003
    Publication date: November 6, 2003
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • P38MAPK inhibitor and uses thereof
    Publication number: 20030207849
    Abstract: The present invention demonstrates that p38MAPK inhibitor induces low density lipoprotein receptor expression 6-8 fold, and further provides the application of such inhibitor in the treatment of hypercholesterolemia.
    Type: Application
    Filed: April 8, 2003
    Publication date: November 6, 2003
    Applicant: Board of Trustees of University of Arkansas
    Inventors: Kamal D. Mehta, Rajesh P. Singh
  • Fungicidal carboxamides
    Patent number: 6642392
    Abstract: Compounds of Formula I are disclosed which are useful as fungicides wherein X is —O—, —CH(R11)— or ═C(R11)—; R1 is H or C1-C2 alkyl; R2 is H; C1-C6 alkyl; C3-C6 cycloalkyl; or phenyl optionally substituted with halogen, cyano, C1-C2 alkyl or C1-C2 alkoxy; and R3-R11 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula I and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula I.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: November 4, 2003
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Gregory Steven Basarab, Douglas Brian Jordan, Thomas Arend Lessen, Stephen L. Hansen
  • Mutated herpes simplex virus type 1 thymidine kinases and uses thereof
    Publication number: 20030202964
    Abstract: The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.
    Type: Application
    Filed: June 9, 2003
    Publication date: October 30, 2003
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Cesar Compadre, Richard Drake, Trenton Hinds, Barry Hurlburt, Tammy Rechtin
  • Uterine Magnetomyography
    Publication number: 20030199749
    Abstract: The present invention is directed to satisfying the need to measure and monitor uterine activity non-invasively and accurately. Using superconducting quantum interference device sensors, we have established the feasibility of recording uterine contractile activity with high enough spatial-temporal resolution to determine the regions of localized activation and propagation over the uterus. With the large surface area and the shape of the array, spatial-temporal recordings of uterine activity were obtained using 151 sensors yielding a better insight into the mechanism of uterine contraction. By obtaining a contour plot of the magnetic field distribution, we were able to localize the areas of activation over the uterus during a contraction.
    Type: Application
    Filed: April 9, 2003
    Publication date: October 23, 2003
    Applicant: Board of Trustees of the University of Arkansas
    Inventors: Curtis L. Lowery, Hari Eswaran, Pamela M. Murphy, James D. Wilson
  • Extracellular serine protease
    Publication number: 20030199010
    Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention.
    Type: Application
    Filed: June 13, 2003
    Publication date: October 23, 2003
    Applicant: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood
  • Methods for the early diagnosis of ovarian cancer
    Patent number: 6627403
    Abstract: The disclosed nucleic acid primer sets, used in combination with quantitative amplification (PCR) of tissue cDNA, can indicate the presence of specific proteases in a tissue sample. The detected proteases are themselves specifically overexpressed in certain cancers, and their presence may serve for early detection of associated ovarian and other malignancies, and for the design of interactive therapies for cancer treatment. More specifically, the present invention relates to the uses of stratum corneum chymotrytic enzyme as a marker for ovarian tumor cells.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: September 30, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Martin J. Cannon, Alessandro Santin
  • Hybrid cholinergic agents and compositions
    Patent number: 6624155
    Abstract: The present invention provides hybrid molecules and methods of synthesizing such hybrid molecules from a cholinergic agent and a bile acid. The hybrid molecules function as cholinergic agents and may be either cholinergic agonists or cholinergic antagonists. Further disclosed herein are compositions comprising hybrid cholinergic agents and methods of making such compositions. Methods of treating a patient having a cholinergic disorder are also disclosed.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: September 23, 2003
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Jean-Pierre Raufman, Piotr Zimniak, Kunrong Cheng
  • Methods of making and method of using hybrid cholinergic agents and compositions
    Patent number: 6624156
    Abstract: The present invention provides hybrid molecules and methods of synthesizing such hybrid molecules from a cholinergic agent and a bile acid. The hybrid molecules function as cholinergic agents and may be either cholinergic agonists or cholinergic antagonists. Further disclosed herein are compositions comprising hybrid cholinergic agents and methods of making such compositions. Methods of treating a patient having a cholinergic disorder are also disclosed.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: September 23, 2003
    Assignee: Board of Trustees of the University of Arkansas
    Inventors: Jean-Pierre Raufman, Piotr Zimniak, Kunrong Cheng
  • Uses of antileukoprotease in carcinoma
    Publication number: 20030170759
    Abstract: The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
    Type: Application
    Filed: April 8, 2003
    Publication date: September 11, 2003
    Applicant: Board of Trustees of University of Arkansas
    Inventors: Timothy J. O' Brien, Lowell J. Underwood, Hirotoshi Tanimoto, Kazushi Shigemasa
  • Purified beta1,2-xylosyltransferase and uses thereof
    Publication number: 20030166012
    Abstract: The present invention provides a purified, homogeneous plant enzyme that adds a &bgr;-1,2-linked xylose to the &bgr;-inked mannose on the N-linked oligosaccharides of storage glycoproteins. This &bgr;1,2-xylosyltransferase was purified from the microsomal fraction of soybean cells approximately 51,000-fold. Also provided is polyclonal antiserum recognizing this &bgr;1,2-xylosyltransferase enzyme and uses thereof.
    Type: Application
    Filed: April 11, 2003
    Publication date: September 4, 2003
    Applicant: The Board of Trustees of University of Arkansas
    Inventors: Alan D. Elbein, Gary A. Bannon
  • Method of doping silicon, metal doped silicon, method of making solar cells, and solar cells
    Patent number: 6613653
    Abstract: A low temperature process for forming a metal doped silicon layer in which a silicon layer is deposited onto a substrate at low temperatures, with a metal doping layer then deposited upon the silicon layer. This structure is then annealed at low temperatures to form a metal doped semiconductor having greater than about 1×1020 dopant atoms per cm3 of silicon.
    Type: Grant
    Filed: December 31, 2001
    Date of Patent: September 2, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Hameed A. Naseem, M. Shahidul Haque, William D. Brown
  • Mutated herpes simplex virus type 1 thymidine kinases and uses thereof
    Patent number: 6610289
    Abstract: The present invention provides new site-specific HSV-thymidine kinase mutants with improved nucleoside analog metabolizing activity due to low or no thymidine phosphorylation ability. Also provided is a method of killing target cells using such mutants combined with a prodrug.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: August 26, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Richard Drake, Trenton Hinds, Cesar Compadre, Barry Hurlburt, Tammy Rechtin
  • Methods of making and using cubic boron nitride composition, coating and articles made therefrom
    Patent number: 6607782
    Abstract: Methods for coating a substrate and methods of shaping a workpiece comprise formation and use, respectively, of a surface or substrate comprising a first phase selected from nitrides, carbides. carbonitrides, borides, sulphides, chalcogenides, oxides, and silicides, and a second phase selected from nitrides, carbides, carbonitrides, borides, sulphides, chalcogenides, oxides, and silicides, wherein said second phase comprises a multiplicity of discrete portions positioned into the first phase, with these multiplicity of portions comprising a continuous second phase, and made thereof, coating and articles, especially machining, cutting and shaping tools, wearparts, and methods of making and using the composition, coating and articles.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: August 19, 2003
    Assignees: Board of Trustees of the University of Arkansas, Valenite, Inc.
    Inventors: Ajay P. Malshe, Sharad N. Yedave, William D. Brown, William C. Russell, Deepak G. Bhat
  • p38MAPK inhibitor and uses thereof
    Patent number: 6602896
    Abstract: The present invention demonstrates that p38MAPK inhibitor induces low density lipoprotein receptor expression 6-8 fold, and further provides the application of such inhibitor in the treatment of hypercholesterolemia.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: August 5, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Kamal D. Mehta, Rajesh P. Singh
  • Uses of antileukoprotease in carcinoma
    Patent number: 6602674
    Abstract: The present invention provides a method of detecting/monitoring tumor growth and progression in a tissue by measuring the level of antileukoprotease. Also provided is a method of treating an individual having a tumor by administering antileukoprotease to inhibit the activity of stratum corneum chymotryptic enzyme. Specifically, the tumor is an ovarian carcinoma.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: August 5, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Timothy J. O'Brien, Lowell J. Underwood, Hirotoshi Tanimoto, Kazushi Shigemasa
  • Purified &bgr;1,2-xylosyltransferase and uses thereof
    Patent number: 6593462
    Abstract: The present invention provides a purified, homogeneous plant enzyme that adds a &bgr;-1,2-linked xylose to the &bgr;-linked mannose on the N-linked oligosaccharides of storage glycoproteins. This &bgr;1,2-xylosyltransferase was purified from the microsomal fraction of soybean cells approximately 51,000-fold. Also provided is polyclonal antiserum recognizing this &bgr;1,2-xylosyltransferase enzyme and uses thereof.
    Type: Grant
    Filed: December 22, 2000
    Date of Patent: July 15, 2003
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Alan D. Elbein, Gary A. Bannon