Abstract: The present invention provides a composition comprising adenosine or adenosine triphosphate (ATP) acting as an absorption enhancer when combined with a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug. Methods of administering ATP or adenosine to improve the bioavailability of a nutritional material(s) such as nutrients, protein, peptides, vitamins, phytochemicals, minerals, fatty acids, or amino acids or a drug are described.
Type:
Grant
Filed:
April 27, 2023
Date of Patent:
March 18, 2025
Assignee:
TSI Group Co., Ltd.
Inventors:
John Rathmacher, Lisa Pitchford, Shawn Baier, Larry Kolb, Naji Abumrad, Matthew Legge
Abstract: The disclosed are shelf-stable beta-hydroxyisovaleric acid containing soft gel compositions and methods for making such compositions. In certain aspects, disclosed compositions comprise a plant-based capsule shell and a liquid formulation comprising beta-hydroxyisovaleric acid and at least one excipient, wherein the soft gel capsule is shelf-stable. In certain aspects, the excipient is selected from selected from choline salt, betaine, phosphatidylcholine, alpha-glycerophosphocholine, carnitine, adenosine 5?-triphosphate, or a combination thereof.
Type:
Application
Filed:
November 4, 2024
Publication date:
February 20, 2025
Applicant:
TSI Group Co., Ltd.
Inventors:
Martin Purpura, Jie Gu, Xiong Zheng, Lingwei Dai, Yaohua Zhang, Ralf Jäger
Abstract: The disclosed are shelf-stable beta-hydroxyisovaleric acid containing soft gel compositions and methods for making such compositions. In certain aspects, disclosed compositions comprise a plant-based capsule shell and a liquid formulation comprising beta-hydroxyisovaleric acid and at least one excipient, wherein the soft gel capsule is shelf-stable. In certain aspects, the excipient is selected from selected from choline salt, betaine, phosphatidylcholine, alpha-glycerophosphocholine, carnitine, adenosine 5?-triphosphate, or a combination thereof.
Type:
Grant
Filed:
March 30, 2021
Date of Patent:
November 5, 2024
Assignee:
TSI Group Co. Ltd.
Inventors:
Martin Purpura, Ralf Jäger, Jie Gu, Xiong Zheng, Lingwei Dai, Yaohua Zhang
Abstract: Disclosed is a method for preparing salicylamine acetate. The method comprises the steps of: (1) carrying out amino protection on salicylaldehyde having a structure represented by formula 1 to obtain a compound having a structure represented by formula 2; and (2) carrying out acid hydrolysis to the compound having a structure represented by formula 2 and then reacting the acid-hydrolyzed compound with acetic acid to obtain salicylamine acetate.