Patents Assigned to TSUBOTA LABORATORY, INC.
  • Publication number: 20240366626
    Abstract: To provide a new ophthalmic preparation for myopia suppression. The above-described problem is solved by using an ophthalmic preparation containing bunazosin as an ophthalmic preparation for myopia suppression. This ophthalmic preparation for myopia suppression is effective for myopia suppression.
    Type: Application
    Filed: May 17, 2022
    Publication date: November 7, 2024
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Heonuk JEONG, Toshihide KURIHARA, Kazuo TSUBOTA
  • Publication number: 20240366959
    Abstract: To provide a device and a method for preventing, improving, or preventing a worsening of depression by irradiating light having specific wavelengths, such as violet light, as well as a method for operating the device. The above-described problem is solved by a device and a method used for the purpose of preventing, improving, or preventing a worsening of depression by irradiating a subject with violet light having a wavelength within a range of 360 to 400 nm. An operating method of a device is a method for operating a device including irradiation means for irradiating a subject with violet light having a wavelength within a range of 360 to 400 nm and used for the purpose of preventing, improving, or preventing a worsening of depression.
    Type: Application
    Filed: June 13, 2024
    Publication date: November 7, 2024
    Applicants: TSUBOTA LABORATORY, INC., SUMITOMO PHARMA CO., LTD.
    Inventors: Motoshi HAYANO, Kazuo TSUBOTA, Yoshihiro NODA
  • Publication number: 20240210736
    Abstract: A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.
    Type: Application
    Filed: March 11, 2024
    Publication date: June 27, 2024
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Shinichi IKEDA, Xiaoyan JIANG, Kazuo TSUBOTA, Toshihide KURIHARA
  • Publication number: 20230364441
    Abstract: A device and a method for inhibiting thinning of a choroid. A choroidal thinning inhibiting device including a light source that emits violet light having a wavelength within a range from 360 nm to 400 nm, the choroidal thinning inhibiting device inhibiting thinning of a choroid by irradiation with the violet light. This device may further include a control mechanism that controls an irradiance and an irradiation time of the violet light, can be applied to ocular diseases selected from age-related macular degeneration, glaucoma, diabetic retinopathy, macular edema, eye strain, retinal vascular occlusion, triangle syndrome, central serous chorioretinopathy, retinitis pigmentosa, presbyopia, cataracts, and the like that are based on inadequate blood flow or reduced blood flow, and can be expected to prevent and treat such ocular diseases.
    Type: Application
    Filed: September 16, 2021
    Publication date: November 16, 2023
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Xiaoyan JIANG, Kiwako MORI, Toshihide KURIHARA, Kazuo TSUBOTA
  • Patent number: 11813299
    Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.
    Type: Grant
    Filed: May 15, 2018
    Date of Patent: November 14, 2023
    Assignees: TSUBOTA LABORATORY, INC., ROHTO PHARMACEUTICAL CO., LTD.
    Inventors: Kazuo Tsubota, Toshihide Kurihara
  • Publication number: 20230218164
    Abstract: A simple diagnosis assisting device (10) for keratoconus and/or astigmatism, including a mobile terminal (10A) including a camera (2) and a transceiver function (3), and integrally or separately provided with a light source (1) for simultaneously projecting ring light onto both eyes. The light source (1) emits the ring light upon being attached to the mobile terminal (10A) in a case of being separately provided to the mobile terminal (10A), and emits the ring light from the mobile terminal (10A) in a case of being integrally provided to the mobile terminal (10A). The camera (2) simultaneously captures a projected image of both eyes onto which the ring light is projected. The ring light may be multiplex ring light or simplex ring light, and is configured in a ring shape by a plurality of point light sources or is configured in a ring shape by a single linear light source.
    Type: Application
    Filed: March 10, 2022
    Publication date: July 13, 2023
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Kazuo TSUBOTA, Hidenaga KOBASHI, Naoko KATO
  • Publication number: 20210308481
    Abstract: To provide a brain wave and cell activity control device and method based on light stimulation in which light having a specific wavelength, such as violet light, is irradiated using continuous light or a specific blinking frequency, and a device for improvement, prevention, or increase in brain function. The above-described problem is solved by a brain wave and cell activity control device, based on light stimulation, that controls brain waves or cell activity by irradiating light having a specific wavelength onto a subject using continuous light or a specific blinking frequency.
    Type: Application
    Filed: August 1, 2019
    Publication date: October 7, 2021
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Motoshi HAYANO, Kazuo TSUBOTA
  • Publication number: 20210228901
    Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.
    Type: Application
    Filed: April 16, 2021
    Publication date: July 29, 2021
    Applicants: TOSHIBA MATERIALS CO., LTD., TSUBOTA LABORATORY, INC.
    Inventors: Masahiko YAMAKAWA, Hidemasa TORII, Toshihide KURIHARA, Kazuo TSUBOTA
  • Publication number: 20210023384
    Abstract: To provide a device and a method for strengthening a cornea or a sclera or suppressing a progression of a disease in a non-invasive manner, enabling treatment in daily life without treatment in a confined state at a medical institution for a fixed period of time and without ablation of the corneal epithelium as in conventional corneal crosslinking. The above-described problem is solved by a non-invasive cornea and sclera strengthening device that irradiates violet light toward an eye administered with an administration agent used to strengthen a corneal tissue or a scleral tissue, and is configured so that an irradiance of the violet light onto a surface of the eye is within a range of 0.1 to 1 mW/cm2, and a time of irradiation of the violet light onto the eye is within a range of one to five hours per day.
    Type: Application
    Filed: March 19, 2019
    Publication date: January 28, 2021
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Hidenaga KOBASHI, Kazuo TSUBOTA
  • Patent number: 10865134
    Abstract: A wavelength-selective transmissive glass has a light transmittance Tmore than 315 nm and 400 nm or less at a wavelength of more than 315 nm and 400 nm or less represented by the formula shown below of 1% or more in terms of a plate thickness of 6 mm and a light transmittance T315 nm or less at a wavelength of 315 nm or less represented by the formula shown below of 60% or less in terms of a plate thickness of 6 mm. Ak is a weighting factor at a wavelength k (nm) for calculating T (light transmittance) defined in ISO-9050:2003, and Tk is a transmittance at the wavelength k (nm) in terms of a plate thickness of 6 mm: Tmore than 315 nm and 400 nm or less=(?k=more than 315400Ak×Tk)/(?k=more than 315400Ak) T315 nm or less=(?k=300315Ak×Tk)/(?k=300315Ak).
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 15, 2020
    Assignees: AGC Inc., TSUBOTA LABORATORY, INC.
    Inventors: Kensuke Nagai, Tetsuya Nakashima, Yutaka Kuroiwa, Hiroyuki Hijiya, Masamichi Tanida, Akio Koike, Manabu Nishizawa, Kazuo Tsubota, Toshihide Kurihara, Hidemasa Torii
  • Patent number: 10823982
    Abstract: The purpose of the present invention is to provide a myopia treatment device. A myopia treatment device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia. Or, the myopia treatment device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: November 3, 2020
    Assignee: TSUBOTA LABORATORY, INC.
    Inventors: Kazuo Tsubota, Kazuno Negishi, Hidemasa Torii, Toshihide Kurihara
  • Publication number: 20200229973
    Abstract: To provide a spraying device and a spraying method for moisture mist that supply at least a micro liquid to the eye, and can be used for dry eye symptom relief, drug delivery, allergy prevention, relaxation, and the like. The above-described problem is solved by a spraying device (1, 31) that supplies at least a micro liquid, and includes a spraying element (16) that sprays a mist-like substance containing the micro liquid onto a local region (50). The raw material is a liquid raw material or a solid raw material that may include a medicinal additive. The medicinal additive is preferably selected from among menthol, analgesics, antibiotics, antiallergic agents, steroids, intraocular pressure-lowering agents, and the like. The spraying device (1, 31) may be an eyeglasses-type spraying device (1) in which the local region (50) is configured by a rim (3) and a temple (6) of eyeglasses, or a cup-type spraying device (31) in which the local region (50) includes an opening (32).
    Type: Application
    Filed: November 27, 2019
    Publication date: July 23, 2020
    Applicant: TSUBOTA LABORATORY, INC.
    Inventor: Kazuo TSUBOTA
  • Patent number: 10660182
    Abstract: To provide a display system such as a smartphone, a game console, a personal computer, or a liquid crystal television, including a light-emitting element that irradiates light having a specific wavelength toward a user. The above-described problem is solved by a display system (1) including a first light-emitting element (6) that emits light used for image display, a second light-emitting element (3) that irradiates light (7) within a wavelength range of 360 nm to 400 nm, inclusive, toward a user, and a control unit (10) that controls irradiation of the light (7) from the second light-emitting element (3).At this time, the second light-emitting element (3) may be a single light-emitting element integrated with the first light-emitting element (6) or a light-emitting element provided separately from the first light-emitting element (6).
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: May 19, 2020
    Assignee: TSUBOTA LABORATORY, INC.
    Inventor: Kazuo Tsubota
  • Publication number: 20200150457
    Abstract: A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.
    Type: Application
    Filed: September 5, 2019
    Publication date: May 14, 2020
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Shinichi IKEDA, Xiaoyan JIANG, Kazuo TSUBOTA, Toshihide KURIHARA
  • Publication number: 20200092971
    Abstract: To provide a display system such as a smartphone, a game console, a personal computer, or a liquid crystal television, including a light-emitting element that irradiates light having a specific wavelength toward a user. The above-described problem is solved by a display system (1) including a first light-emitting element (6) that emits light used for image display, a second light-emitting element (3) that irradiates light (7) within a wavelength range of 360 nm to 400 nm, inclusive, toward a user, and a control unit (10) that controls irradiation of the light (7) from the second light-emitting element (3). At this time, the second light-emitting element (3) may be a single light-emitting element integrated with the first light-emitting element (6) or a light-emitting element provided separately from the first light-emitting element (6).
    Type: Application
    Filed: December 26, 2017
    Publication date: March 19, 2020
    Applicant: TSUBOTA LABORATORY, INC.
    Inventor: Kazuo TSUBOTA
  • Publication number: 20190129204
    Abstract: The purpose of the present invention is to provide a myopia treatment device. A myopia treatment device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia. Or, the myopia treatment device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits violet light having a wavelength within a range of 360 nm to 400 nm inclusive and thus treats myopia.
    Type: Application
    Filed: October 9, 2018
    Publication date: May 2, 2019
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Kazuo Tsubota, Kazuno Negishi, Hidemasa Torii, Toshihide Kurihara
  • Publication number: 20190121165
    Abstract: To provide a translucent member that has the effect of lowering triglycerides, increasing IRS-2, and the like. The above-described problem is solved by a translucent member (1) that blocks or suppresses transmission of at least light that is received by an eye and has a wavelength of 460 nm. The translucent member (1) may be an eyeglass lens or eyeglasses as a whole. The eyeglasses (1) preferably comprise a lens (2) that blocks or suppresses transmission of at least light having a wavelength of 460 nm, and a rim (3) that blocks or suppresses transmission of at least light having a wavelength of 460 nm. The rim (3) preferably comprise a projecting portion (3a) for decreasing a gap between the rim (3) and a face of an eyeglass wearer or eliminating the gap by coming into contact with the face.
    Type: Application
    Filed: April 7, 2017
    Publication date: April 25, 2019
    Applicant: TSUBOTA LABORATORY, INC.
    Inventors: Kazuo TSUBOTA, Masahiko AYAKI
  • Publication number: 20180351050
    Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.
    Type: Application
    Filed: July 25, 2018
    Publication date: December 6, 2018
    Applicants: TOSHIBA MATERIALS CO., LTD., TSUBOTA LABORATORY, INC.
    Inventors: Masahiko Yamakawa, Hidemasa Torii, Toshihide Kurihara, Kazuo Tsubota
  • Patent number: 10133092
    Abstract: The purpose of the present invention is to provide a myopia prevention device. A myopia prevention device of the present invention comprises a light transmission part selected from a group consisting of an eyesight correcting tool, an eye protection tool, a face protection tool, a sunshade, a display device, a window, a wall, a light source covering, and a coating material. The light transmission part of the device transmits light having a wavelength within a range of 350 nm to 400 nm inclusive and thus suppresses the occurrence and progression of myopia. Further, a myopia prevention device comprises a light emission part selected from a group consisting of lighting equipment, a display device, and a light irradiation device. The light emission part of the device emits light having a wavelength within a range of 350 nm to 400 nm inclusive and thus suppresses the occurrence and progression of myopia.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: November 20, 2018
    Assignee: TSUBOTA LABORATORY, INC.
    Inventors: Kazuo Tsubota, Kazuno Negishi, Hidemasa Torii, Toshihide Kurihara
  • Patent number: D1067314
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: March 18, 2025
    Assignees: JINS HOLDING Inc., TSUBOTA LABORATORY, Inc.
    Inventor: Daisuke Kaneda