Patents Assigned to Tufts Medical Center
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Publication number: 20250065028Abstract: An extension cannula and in-line connector for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blow flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: ApplicationFiled: November 8, 2024Publication date: February 27, 2025Applicant: Tufts Medical Center, Inc.Inventor: Navin K. KAPUR
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Patent number: 12186469Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: GrantFiled: August 24, 2023Date of Patent: January 7, 2025Assignee: Tufts Medical Center, Inc.Inventor: Navin K. Kapur
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Publication number: 20240407752Abstract: The disclosed subject matter provides systems and methods for predicting a spontaneous preterm birth based on transvaginal ultrasound images of a subject. An example method can include providing a preterm birth prediction model, obtaining one or more transvaginal ultrasound images of the subject, each including cervical features, determining measurements of a plurality of cervical structure features from the one or more ultrasound images, assessing, using the preterm birth prediction model, cervical health of the subject based on the measurements of the plurality of cervical structure features, and calculating the spontaneous preterm birth risk based on the assessed cervical health, using the preterm birth prediction model.Type: ApplicationFiled: June 10, 2024Publication date: December 12, 2024Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, WISCONSIN ALUMNI RESEARCH FOUNDATION, TUFTS MEDICAL CENTERInventors: Kristin M. Myers, Sachin Jambawalikar, Qi Yan, Alicia B. Dagle, Yucheng Liu, Ronald Wapner, Helen Feltovich, Michael House
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Publication number: 20240408074Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.Type: ApplicationFiled: April 19, 2024Publication date: December 12, 2024Applicants: 60 DEGREES PHARMACEUTICALS LLC, Tufts Medical Center, Inc., Yale UniverstiyInventors: Geoffrey S. Dow, Bryan L. Smith, Edouard Vannier, Peter J. Krause
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Publication number: 20240390359Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.Type: ApplicationFiled: April 19, 2024Publication date: November 28, 2024Applicants: 60 DEGREES PHARMACEUTICALS LLC, Tufts Medical Center, Inc.Inventors: Geoffrey S. DOW, Bryan L. Smith, Edouard Vannier
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Patent number: 12091466Abstract: The present invention relates to methods of treatment of light chain amyloidosis and other CD38-positive hematological malignancies with anti-CD38 antibodies.Type: GrantFiled: August 5, 2020Date of Patent: September 17, 2024Assignees: JANSSEN BIOTECH, INC., TUFTS MEDICAL CENTER, INC.Inventors: Chakra Chaulagain, Raymond Comenzo, Parul Doshi, Xun Ma, Amy Sasser
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Patent number: 12090291Abstract: Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to penetrate a wall of a sigmoid, transverse, straight, or sagittal sinus of the patient, a one-way valve, a hollow passageway extending between the second end and the one-way valve such that cerebrospinal fluid can be drained through the second end and out through the valve, and a mechanism coupled to the shunt and configured to anchor the shunt at a desired location proximal to the subarachnoid space.Type: GrantFiled: February 7, 2022Date of Patent: September 17, 2024Assignee: Tufts Medical Center, Inc.Inventors: Carl Heilman, Adel M. Malek
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Patent number: 12060397Abstract: The present application provides methods for preparing soluble lipidated ligand agents comprising a ligand entity and a lipid entity, and in some embodiments, provides relevant parameters of each of these components, thereby enabling appropriate selection of components to assemble active agents for any given target of interest.Type: GrantFiled: November 12, 2021Date of Patent: August 13, 2024Assignees: Tufts Medical Center, Trustees of Tufts College, On Target Therapeutics LLCInventors: Charles Cohen, Krishna Kumar, Jamie Raudensky Doyle, Alan S. Kopin
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Patent number: 12053501Abstract: The present disclosure relates to, among other things, compositions and methods for treating an inflammatory condition including, but not limited to, ocular inflammation, dry eye disease, and ocular neuropathic pain. One aspect of the present disclosure relates to a composition comprising (a) chemerin or a fragment or analog thereof and (b) a lipid entity linked to the chemerin or fragment or analog thereof.Type: GrantFiled: November 8, 2021Date of Patent: August 6, 2024Assignees: Tufts Medical Center, Trustees of Tufts College, On Target Therapeutics LLCInventors: Charles Cohen, Krishna Kumar, Alan S. Kopin, Benjamin N. Harwood, Venkata S. Raman, Pedram Hamrah
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Patent number: 11998270Abstract: The invention provides methods of diagnosing neuropathic corneal pain by the detection of neuromas, such as micro-neuromas, on the cornea. The invention also features systems for detecting the presence of anatomical features located on an ocular tissue surface that may be a marker for neuropathic corneal pain. The systems feature an in vivo confocal microscope and a computer N programmed with a neural network to automate the analysis of the microscope images. The invention provides methods of using the system to identify a micro-neuroma in images collected of an ocular surface and methods of diagnosing neuropathic corneal pain and monitoring treatment of neuropathic corneal pain using a system of the invention.Type: GrantFiled: April 26, 2019Date of Patent: June 4, 2024Assignees: Tufts Medical Center, Inc., President and Fellows of Harvard CollegeInventors: Pedram Hamrah, Neslihan Dilruba Koseoglu, Andrew Beam
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Patent number: 11932650Abstract: The present disclosure relates to derivatized agelastatin compounds and methods for the treatment, prevention, or delay of cancer, comprising administering a therapeutically effect amount of the derivatized agelastatin compounds, a pharmaceutically acceptable salt thereof, or a composition thereof to a subject in need thereof. Methods for making the derivatized agelastatin compounds are also provided.Type: GrantFiled: May 11, 2018Date of Patent: March 19, 2024Assignees: Massachusetts Institute of Technology, Tufts Medical Center, Inc.Inventors: Mohammad Movassaghi, Alyssa H. Antropow, Rachel J. Buchsbaum, Kun Xu
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Patent number: 11872361Abstract: Systems and methods are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient's superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient's Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The system may include sensors to determine the degree of occlusion of the superior vena cava. The occlusion system may be used to reduce volume in a heart and facilitate a cardiac procedure. The occlusion system may be used to relieve an overloaded chamber during and/or after deploying a VAD.Type: GrantFiled: November 19, 2020Date of Patent: January 16, 2024Assignee: Tufts Medical Center, Inc.Inventors: Navin K. Kapur, Richard H. Karas
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Publication number: 20230398279Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: ApplicationFiled: August 24, 2023Publication date: December 14, 2023Applicant: Tufts Medical Center, Inc.Inventor: Navin K. KAPUR
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Publication number: 20230355952Abstract: We provide herein a method of preventing or limiting the effects of heart failure in a human patient that has sustained myocardial infarction by reducing maladaptive cardiac remodeling in the patient. The method comprises percutaneously inserting a transvalvular blood pump, comprising a rotor and a cannula, into the patient's vasculature and positioning the cannula across the aortic valve of the patient's heart, with a distal end of the cannula located in the left ventricle of the heart and a proximal end of the pump located in the aorta. The method then comprises, prior to reperfusing the heart, operating the positioned pump to unload the left ventricle at a pumping rate of at least 2.5 L/min of blood flow for a support period between at least 30 minutes and less than 60 minutes. Then, after the support period, the method comprises applying coronary reperfusion therapy to the heart.Type: ApplicationFiled: April 4, 2023Publication date: November 9, 2023Applicants: Tufts Medical Center, Abiomed, Inc.Inventors: Navin K. Kapur, Richard H. Karas, Noam Josephy
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Patent number: 11739161Abstract: The invention provides methods for treating and diagnosing prostate cancer, as well as related positions and kits.Type: GrantFiled: September 13, 2018Date of Patent: August 29, 2023Assignee: Tufts Medical Center, Inc.Inventors: Guo-fu Hu, Shuping Li
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Patent number: 11738131Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: GrantFiled: January 9, 2023Date of Patent: August 29, 2023Assignee: Tufts Medical Center, Inc.Inventor: Navin K. Kapur
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Patent number: 11718646Abstract: The present disclosure relates to, among other things, compounds and methods for treating neuropathic pain, ocular pain, ocular inflammation, and/or dry eye and methods of detecting mutations in specific G-protein coupled receptors, such as missense mutations, and determining the extent to which these mutations alter the pharmacological response of the G-protein coupled receptor.Type: GrantFiled: December 15, 2020Date of Patent: August 8, 2023Assignees: Tufts Medical Center, Trustees of Tufts CollegeInventors: Alan S. Kopin, Krishna Kumar, Jamie Raudensky Doyle
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Publication number: 20230241361Abstract: Systems and methods and devices are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient’s superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient’s Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The occlusion device may include a lumen obstructed by a relief valve that may permit fluid flow through the occlusion device to release an excessive build-up of pressure.Type: ApplicationFiled: February 16, 2023Publication date: August 3, 2023Applicant: Tufts Medical Center, Inc.Inventors: Navin K. KAPUR, Richard KARAS
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Patent number: 11672418Abstract: Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.Type: GrantFiled: October 7, 2020Date of Patent: June 13, 2023Assignee: Tufts Medical Center, Inc.Inventors: Pedram Hamrah, William Warr Binotti, Ricardo Menon Nose
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Publication number: 20230158223Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: ApplicationFiled: January 9, 2023Publication date: May 25, 2023Applicant: Tufts Medical Center, Inc.Inventor: Navin K. KAPUR