Patents Assigned to Tufts Medical Center, Inc.
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Publication number: 20240408074Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.Type: ApplicationFiled: April 19, 2024Publication date: December 12, 2024Applicants: 60 DEGREES PHARMACEUTICALS LLC, Tufts Medical Center, Inc., Yale UniverstiyInventors: Geoffrey S. Dow, Bryan L. Smith, Edouard Vannier, Peter J. Krause
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Publication number: 20240390359Abstract: Methods and compositions for treating or preventing non-viral tick-borne diseases and symptoms thereof by administering a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed. Kits including a means for testing for a non-viral tick-borne disease and/or symptoms thereof and a long half-life 8-aminoquinoline, such as tafenoquine, are disclosed.Type: ApplicationFiled: April 19, 2024Publication date: November 28, 2024Applicants: 60 DEGREES PHARMACEUTICALS LLC, Tufts Medical Center, Inc.Inventors: Geoffrey S. DOW, Bryan L. Smith, Edouard Vannier
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Patent number: 12090291Abstract: Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to penetrate a wall of a sigmoid, transverse, straight, or sagittal sinus of the patient, a one-way valve, a hollow passageway extending between the second end and the one-way valve such that cerebrospinal fluid can be drained through the second end and out through the valve, and a mechanism coupled to the shunt and configured to anchor the shunt at a desired location proximal to the subarachnoid space.Type: GrantFiled: February 7, 2022Date of Patent: September 17, 2024Assignee: Tufts Medical Center, Inc.Inventors: Carl Heilman, Adel M. Malek
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Patent number: 11998270Abstract: The invention provides methods of diagnosing neuropathic corneal pain by the detection of neuromas, such as micro-neuromas, on the cornea. The invention also features systems for detecting the presence of anatomical features located on an ocular tissue surface that may be a marker for neuropathic corneal pain. The systems feature an in vivo confocal microscope and a computer N programmed with a neural network to automate the analysis of the microscope images. The invention provides methods of using the system to identify a micro-neuroma in images collected of an ocular surface and methods of diagnosing neuropathic corneal pain and monitoring treatment of neuropathic corneal pain using a system of the invention.Type: GrantFiled: April 26, 2019Date of Patent: June 4, 2024Assignees: Tufts Medical Center, Inc., President and Fellows of Harvard CollegeInventors: Pedram Hamrah, Neslihan Dilruba Koseoglu, Andrew Beam
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Patent number: 11932650Abstract: The present disclosure relates to derivatized agelastatin compounds and methods for the treatment, prevention, or delay of cancer, comprising administering a therapeutically effect amount of the derivatized agelastatin compounds, a pharmaceutically acceptable salt thereof, or a composition thereof to a subject in need thereof. Methods for making the derivatized agelastatin compounds are also provided.Type: GrantFiled: May 11, 2018Date of Patent: March 19, 2024Assignees: Massachusetts Institute of Technology, Tufts Medical Center, Inc.Inventors: Mohammad Movassaghi, Alyssa H. Antropow, Rachel J. Buchsbaum, Kun Xu
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Patent number: 11872361Abstract: Systems and methods are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient's superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient's Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The system may include sensors to determine the degree of occlusion of the superior vena cava. The occlusion system may be used to reduce volume in a heart and facilitate a cardiac procedure. The occlusion system may be used to relieve an overloaded chamber during and/or after deploying a VAD.Type: GrantFiled: November 19, 2020Date of Patent: January 16, 2024Assignee: Tufts Medical Center, Inc.Inventors: Navin K. Kapur, Richard H. Karas
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Publication number: 20230398279Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: ApplicationFiled: August 24, 2023Publication date: December 14, 2023Applicant: Tufts Medical Center, Inc.Inventor: Navin K. KAPUR
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Patent number: 11738131Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: GrantFiled: January 9, 2023Date of Patent: August 29, 2023Assignee: Tufts Medical Center, Inc.Inventor: Navin K. Kapur
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Patent number: 11739161Abstract: The invention provides methods for treating and diagnosing prostate cancer, as well as related positions and kits.Type: GrantFiled: September 13, 2018Date of Patent: August 29, 2023Assignee: Tufts Medical Center, Inc.Inventors: Guo-fu Hu, Shuping Li
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Publication number: 20230241361Abstract: Systems and methods and devices are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient’s superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient’s Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The occlusion device may include a lumen obstructed by a relief valve that may permit fluid flow through the occlusion device to release an excessive build-up of pressure.Type: ApplicationFiled: February 16, 2023Publication date: August 3, 2023Applicant: Tufts Medical Center, Inc.Inventors: Navin K. KAPUR, Richard KARAS
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Patent number: 11672418Abstract: Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.Type: GrantFiled: October 7, 2020Date of Patent: June 13, 2023Assignee: Tufts Medical Center, Inc.Inventors: Pedram Hamrah, William Warr Binotti, Ricardo Menon Nose
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Publication number: 20230158223Abstract: An extension cannula for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blood flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: ApplicationFiled: January 9, 2023Publication date: May 25, 2023Applicant: Tufts Medical Center, Inc.Inventor: Navin K. KAPUR
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Patent number: 11624068Abstract: Provided herein are compositions and methods for improving immune system function. In particular, provided herein are compositions, methods, and uses of YY1 and EZH2 inhibitors for preventing and reversing T-cell exhaustion (e.g., for use in immunotherapy).Type: GrantFiled: July 14, 2017Date of Patent: April 11, 2023Assignee: Tufts Medical Center, Inc.Inventors: Richard P. Junghans, Mumtaz Yaseen
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Patent number: 11612739Abstract: Disclosed are devices, electrodes, systems, methods, and other implementations, including a system that includes a subdural sound comprising an elongated structure configured to be placed within a subdural space of a brain area of a patient, and an electrode comprising an elongated body, a plurality of electrical contacts disposed on a substantially flat first side of the elongated body, and a soundage channel defined along a longitudinal axis of the electrode and open at opposite ends. The soundage channel at the leading end of the electrode is fitted on the trailing end of the elongated structure of the subdural sound so as to be advanced, when the subdural sound is placed within the subdural space, to a target site in the subdural space for tangential placement on target tissue in the subdural space of the brain area.Type: GrantFiled: September 27, 2019Date of Patent: March 28, 2023Assignee: Tufts Medical Center, Inc.Inventor: James Kryzanski
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Patent number: 11612725Abstract: Systems and methods and devices are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient's superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient's Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The occlusion device may include a lumen obstructed by a relief valve that may permit fluid flow through the occlusion device to release an excessive build-up of pressure.Type: GrantFiled: November 20, 2020Date of Patent: March 28, 2023Assignee: Tufts Medical Center, Inc.Inventors: Navin K. Kapur, Richard H. Karas
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Patent number: 11584934Abstract: Provided herein are compositions and methods for improving immune system function. In particular, provided herein are compositions, methods, and uses of YY1 and EZH2 inhibitors for preventing and reversing T-cell exhaustion (e.g., for use in immunotherapy).Type: GrantFiled: July 14, 2017Date of Patent: February 21, 2023Assignee: Tufts Medical Center, Inc.Inventors: Richard P. Junghans, Mumtaz Yaseen
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Patent number: 11547786Abstract: An extension cannula and in-line connector for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blow flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: GrantFiled: May 12, 2022Date of Patent: January 10, 2023Assignee: Tufts Medical Center, Inc.Inventor: Navin K. Kapur
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Publication number: 20220401718Abstract: Systems and methods are provided for treating conditions such as heart failure and/or pulmonary hypertension by at least partially occluding flow through the superior vena cava for an interval spanning multiple cardiac cycles. A catheter with an occlusion device is provided along with a controller that actuates a drive mechanism to provide at least partial occlusion of the patient's superior vena cava, which reduces cardiac filling pressures, and induces a favorable shift in the patient's Frank-Starling curve towards healthy heart functionality and improved cardiac performance. The system may include sensors to determine the degree of occlusion of the superior vena cava. The occlusion system may be used to reduce volume in a heart and facilitate a cardiac procedure. The occlusion system may be used to relieve an overloaded chamber during and/or after deploying a VAD.Type: ApplicationFiled: November 19, 2020Publication date: December 22, 2022Applicant: Tufts Medical Center, Inc.Inventors: Navin K. KAPUR, Richard KARAS
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Publication number: 20220346640Abstract: Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.Type: ApplicationFiled: October 7, 2020Publication date: November 3, 2022Applicants: Tufts Medical Center, Inc., Tufts Medical Center, Inc.Inventors: Pedram Hamrah, William Warr Binotti, Ricardo Menon Nose
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Publication number: 20220280709Abstract: An extension cannula and in-line connector for use with a conventional ECMO return cannula is provided. The extension cannula includes a flexible conduit transitionable between a collapsed insertion state and an expanded deployed state when in communication with blow flow from an ECMO machine via the ECMO return cannula. The extension cannula may be positioned through a conventional ECMO return cannula such that the proximal end of the flexible conduit is disposed within and proximal to the end of the ECMO return cannula, while the distal end of the flexible conduit is disposed in a patient's thoracic aorta to deliver oxygenated blood directly to the patient's thoracic aorta via one or more pores at the distal region of the flexible conduit to improve cerebral oxygenation, maintain systemic arterial pulsatility, and reduce the potential for end-organ injury.Type: ApplicationFiled: May 12, 2022Publication date: September 8, 2022Applicant: Tufts Medical Center, Inc.Inventor: Navin K. KAPUR