Patents Assigned to Tufts University
  • Patent number: 11802270
    Abstract: The present invention provides, among other things, methods for producing platelets including the steps of providing a silk membrane about 2 ?m and 100 ?m thick, inclusive, contacting the silk membrane with a porogen to form a porous silk membrane comprising at least one silk wall defining a lumen, associating the porous silk membrane with stromal derived factor-1? and at least one functionalizing agent, forming a three dimensional silk matrix comprising interconnected pores wherein the pores have a diameter of between about 5 and 500 ?m, inclusive, wherein the silk matrix is formed around at least a portion of the porous silk membrane, introducing a plurality of megakaryocytes to the silk matrix such that the megakaryocytes are located at least partially within the porous silk matrix, and stimulating the plurality of megakaryocytes to produce platelets. Also provided are various new compositions and methods of making those compositions.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: October 31, 2023
    Assignees: Tufts University, University of Pavia
    Inventors: Alessandra Balduini, David L. Kaplan, Lindsay Wray, Christian Andrea Di Buduo, Lorenzo Tozzi
  • Patent number: 11473107
    Abstract: Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition.
    Type: Grant
    Filed: July 15, 2019
    Date of Patent: October 18, 2022
    Assignee: Tufts University
    Inventor: Thomas J. Diefenbach
  • Patent number: 11447753
    Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: September 20, 2022
    Assignees: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College (AKA Tufts University)
    Inventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein
  • Patent number: 11241450
    Abstract: This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs for treating various disorders including, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions, e.g., psoriasis and rheumatoid arthritis.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: February 8, 2022
    Assignee: Tufts University
    Inventors: Philip G. Haydon, Jinbo Lee
  • Patent number: 11229910
    Abstract: Described herein are microfluidic devices and systems for high density cell culture and/or high throughput cell assays. Methods of using the same are also provided herein. In some embodiments, the microfluidic devices and systems described herein provide rapid and automated trapping of single embryos in ordered arrays.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: January 25, 2022
    Assignees: President and Fellows of Harvard College, Tufts University
    Inventors: Richard Novak, Donald E. Ingber, Michael Levin, Rachelle Prantil-Baun
  • Patent number: 11229726
    Abstract: In some embodiments, the present invention provides methods for making resorbable ear tubes including the steps of providing a silk fibroin solution, and forming a silk ear tube from the silk fibroin solution, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbable. In some embodiments, the present invention also provides methods for treating otitis media including the step of introducing a silk ear tube into the ear canal of a subject, wherein the silk ear tube is less than 2 mm in length and has an outer diameter of less than 1.5 mm, and wherein the silk ear tube is resorbed by the subject.
    Type: Grant
    Filed: April 1, 2021
    Date of Patent: January 25, 2022
    Assignees: Tufts University, Massachusetts Eye and Ear Infirmary, The General Hospital Corporation
    Inventors: David Kaplan, Michael Whalen, Christopher Hartnick
  • Patent number: 11147282
    Abstract: Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
    Type: Grant
    Filed: March 21, 2019
    Date of Patent: October 19, 2021
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David Kaplan, Benedetto Marelli, Mark Brenckle
  • Patent number: 11135195
    Abstract: Provided herein are compositions and methods for treating, preventing, and reversing malnutrition. In particular, provided herein are compositions and methods for facilitating cognitive repair and preventing obesity (e.g. in children).
    Type: Grant
    Filed: December 20, 2016
    Date of Patent: October 5, 2021
    Assignee: Tufts University
    Inventors: Susan Roberts, Amy Krauss, Edward Saltzman
  • Patent number: 11124536
    Abstract: This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma and inflammatory conditions.
    Type: Grant
    Filed: January 27, 2020
    Date of Patent: September 21, 2021
    Assignee: Tufts University
    Inventors: Philip G. Haydon, Jinbo Lee
  • Patent number: 11072627
    Abstract: This disclosure relates to uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those UDP derivatives and methods of using those derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease) and traumatic CNS injury, as well as pain.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: July 27, 2021
    Assignee: Tufts University
    Inventors: Philip G. Haydon, Jinbo Lee, Jinghui Dong, Stephen Moss, Raquel Revilla-Sanchez
  • Patent number: 11009792
    Abstract: The present application provides novel methods for the fabrication of nanostructures. More specifically, the invention relates to direct electron beam lithography with the use of silk fibroin as “green” resists.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: May 18, 2021
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Sunghwan Kim, Benedetto Marelli
  • Patent number: 11001685
    Abstract: Protein-protein imprinting of silk fibroin is introduced as a rapid, high-fidelity, and/or high-throughput method for the fabrication of nanoscale structures in silk films, through controlled manipulation of heat and/or pressure. High resolution imprinting on conformal surfaces is also demonstrated.
    Type: Grant
    Filed: February 26, 2018
    Date of Patent: May 11, 2021
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Mark A. Brenckle
  • Patent number: 11001625
    Abstract: Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent, methods, compositions and kits having a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes at least one or a plurality of disease agents that are toxins, for example at least one of a Botulinum toxin or an Anthrax toxin.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: May 11, 2021
    Assignee: Tufts University
    Inventor: Charles B. Shoemaker
  • Publication number: 20210069226
    Abstract: This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs for treating various disorders including, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions, e.g., psoriasis and rheumatoid arthritis.
    Type: Application
    Filed: April 15, 2020
    Publication date: March 11, 2021
    Applicants: TUFTS UNIVERSITY, TUFTS UNIVERSITY
    Inventors: Philip G. Haydon, Jinbo Lee
  • Patent number: 10912862
    Abstract: The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: February 9, 2021
    Assignees: Children's Medical Center Corporation, Tufts University
    Inventors: Joshua R. Mauney, Carlos R. Estrada, David L. Kaplan, Eun Seok Gil
  • Patent number: 10874742
    Abstract: The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better volumetric swelling, biocompatibility and/or degradability when compared to current memory polymers derived from either natural or synthetic materials.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: December 29, 2020
    Assignee: Tufts University
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto, Joseph E. Brown, Rodrigo R. Jose
  • Patent number: 10766950
    Abstract: Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes a disease agent that is a toxin, for example a Clostridium difficile toxin, a Shiga toxin, a ricin toxin, or an anthrax toxin.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: September 8, 2020
    Assignee: TUFTS UNIVERSITY
    Inventor: Charles B. Shoemaker
  • Patent number: 10771088
    Abstract: A tensor decomposition method, system, and computer program product include compressing multi-dimensional data by truncated tensor-tensor decompositions.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 8, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, TUFTS UNIVERSITY, TEL AVIV-YAFO UNIVERSITY
    Inventors: Lior Horesh, Misha E Kilmer, Haim Avron, Elizabeth Newman
  • Patent number: 10758645
    Abstract: The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are compositions and methods of producing soft, flexible ceramic foam with silk polymeric crosslinking to serve as binders. Materials have applications in osteochondral and dental replacement and repair.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: September 1, 2020
    Assignee: Tufts University
    Inventors: Stephanie L. McNamara, Benjamin P. Partlow, David L. Kaplan
  • Publication number: 20200263146
    Abstract: Provided herein are compositions and methods for vaccination and research applications. In particular, provided herein are non-neuroinvasive herpesviruses and alpha herpesviruses and uses thereof.
    Type: Application
    Filed: May 6, 2020
    Publication date: August 20, 2020
    Applicants: Northwestern University, Board of Regents of the University of Nebraska, Trustees of Tufts College (AKA Tufts University)
    Inventors: Gregory A. Smith, Patricia Jane Sollars, Gary Edward Pickard, Ekaterina E. Heldwein