Patents Assigned to Tufts University
  • Publication number: 20210069226
    Abstract: This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs for treating various disorders including, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions, e.g., psoriasis and rheumatoid arthritis.
    Type: Application
    Filed: April 15, 2020
    Publication date: March 11, 2021
    Applicants: TUFTS UNIVERSITY, TUFTS UNIVERSITY
    Inventors: Philip G. Haydon, Jinbo Lee
  • Patent number: 10912862
    Abstract: The technology described herein is directed to compositions comprising at least a first porous biomaterial layer and a second impermeable biomaterial layer and methods relating thereto. In some embodiments, the compositions and methods described herein relate to wound healing, e.g. repair of wounds and/or tissue defects.
    Type: Grant
    Filed: February 5, 2013
    Date of Patent: February 9, 2021
    Assignees: Children's Medical Center Corporation, Tufts University
    Inventors: Joshua R. Mauney, Carlos R. Estrada, David L. Kaplan, Eun Seok Gil
  • Patent number: 10874742
    Abstract: The present application relates to silk fibroin-based materials, methods for making and using the same. Provided materials exhibit shape memory characteristics while showing comparable or better volumetric swelling, biocompatibility and/or degradability when compared to current memory polymers derived from either natural or synthetic materials.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: December 29, 2020
    Assignee: Tufts University
    Inventors: David L. Kaplan, Fiorenzo G. Omenetto, Joseph E. Brown, Rodrigo R. Jose
  • Patent number: 10771088
    Abstract: A tensor decomposition method, system, and computer program product include compressing multi-dimensional data by truncated tensor-tensor decompositions.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: September 8, 2020
    Assignees: INTERNATIONAL BUSINESS MACHINES CORPORATION, TUFTS UNIVERSITY, TEL AVIV-YAFO UNIVERSITY
    Inventors: Lior Horesh, Misha E Kilmer, Haim Avron, Elizabeth Newman
  • Patent number: 10766950
    Abstract: Methods, compositions and kits are provided for treating a subject exposed to or at risk for exposure to a disease agent using a pharmaceutical composition including at least one recombinant binding protein or a source of expression of the binding protein, wherein the binding protein neutralizes a disease agent that is a toxin, for example a Clostridium difficile toxin, a Shiga toxin, a ricin toxin, or an anthrax toxin.
    Type: Grant
    Filed: January 2, 2019
    Date of Patent: September 8, 2020
    Assignee: TUFTS UNIVERSITY
    Inventor: Charles B. Shoemaker
  • Patent number: 10758645
    Abstract: The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are compositions and methods of producing soft, flexible ceramic foam with silk polymeric crosslinking to serve as binders. Materials have applications in osteochondral and dental replacement and repair.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: September 1, 2020
    Assignee: Tufts University
    Inventors: Stephanie L. McNamara, Benjamin P. Partlow, David L. Kaplan
  • Patent number: 10731046
    Abstract: The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.
    Type: Grant
    Filed: July 6, 2018
    Date of Patent: August 4, 2020
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Hu Tao, Benedetto Marelli, Miaomiao Yang
  • Patent number: 10672768
    Abstract: A method for manufacturing a FinFET having a fin that has a fin body includes selecting a desired electrical performance parameter, selecting a base dimension of the fin, identifying a combination of fin-body doping and fin-geometry that causes the FinFET to have the desired electrical performance parameter, doping the fin body according to the identified fin-body doping, and fabricating the fin according to the fin-geometry.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: June 2, 2020
    Assignee: Tufts University
    Inventors: Brad D. Gaynor, Soha Hassoun
  • Patent number: 10632138
    Abstract: This disclosure relates to the use of uridine diphosphate (UDP) derivatives, salts and/or prodrugs thereof for the treatment of inflammatory conditions (e.g., psoriasis) and glaucoma, to prodrugs of UDP derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs for treating various disorders including, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions, e.g., psoriasis and rheumatoid arthritis.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: April 28, 2020
    Assignee: TUFTS UNIVERSITY
    Inventors: Philip G. Haydon, Jinbo Lee
  • Publication number: 20200123498
    Abstract: The disclosure provides methods and compositions for affecting the development of antigen presenting cell (APC, e.g., a macrophage or dendritic cell). The methods include maturing an APC, promoting anti-inflammatory phenotype, promoting development of a T regulatory cell (Treg) from a naive T cell. The methods generally include exposing an APC to a tryptophan derived microbiota metabolite (TDMM), such as an anti-inflammatory or pro-mucosal TDMM, and permitting the APC to mature. In some embodiments, the conditioned APC is exposed to a naive T cell to further promote development of a T regulatory cell (Treg). In some embodiments, the TDMM is selected from the group consisting of indole, indole-3-acetate, 5-hydroxyindole, and indole-3-pyruvate.
    Type: Application
    Filed: March 17, 2017
    Publication date: April 23, 2020
    Applicants: THE TEXAS A&M UNIVERSITY SYSTEM, TRUSTEES OF TUFTS COLLEGE
    Inventors: Robert C. Alaniz, Arul Jayaraman, Kyongbum Lee
  • Publication number: 20200062862
    Abstract: The transmembrane metalloproteinase-disintegrin ADAM8 mediates cell adhesion and shedding of ligands, receptors, and extracellular matrix components. ADAM8 is abundantly expressed in breast tumors and derived metastases compared to normal tissue, especially in triple-negative breast cancers (TNBCs). High ADAM8 levels predicted poor patient outcome, and ADAM8 promoted an aggressive phenotype of TNBC cells in culture. Tumors derived from TNBC cells with ADAM8 knockdown failed to grow beyond a palpable size and displayed poor vascularization. Circulating tumor cells and brain metastases were also significantly reduced. ADAM8 stimulated angiogenesis through release of VEGF-A and cell migration through ?1-integrin activation. Treatment with anti-ADAM8 antibody in vivo resulted in reduced primary tumor burden and reduced metastases. Furthermore, antibody treatment of established tumors profoundly decreased metastases in a resection model.
    Type: Application
    Filed: July 30, 2019
    Publication date: February 27, 2020
    Applicant: Tufts University
    Inventors: Gail Sonenshein, Mathilde Romagnoli, Nora Mineva
  • Publication number: 20200063163
    Abstract: Methods, tip assemblies and kits are provided for introducing material into cells. The tip assemblies include an attachment portion, a channel portion, and a constriction that function to reduce fluid pressure as a fluid passes through the constriction portion from the channel portion, whereby the tip assemblies form pores in the membranes of cells and introduce material into the cells. The material includes for example one selected from the group of: an inorganic compound, a drug, a genetic material, a protein, a carbohydrate, a synthetic polymer, and a pharmaceutical composition.
    Type: Application
    Filed: July 15, 2019
    Publication date: February 27, 2020
    Applicant: Tufts University
    Inventor: Thomas J. Diefenbach
  • Patent number: 10562024
    Abstract: The present disclosure relates to paper-based substrates and apparatus comprising such substrates. The apparatus may include a patterned conductive structure coupled to the paper-based substrate, wherein the patterned conductive structure responds to electromagnetic radiation.
    Type: Grant
    Filed: January 4, 2012
    Date of Patent: February 18, 2020
    Assignee: Tufts University
    Inventors: Fiorenzo Omenetto, David L. Kaplan, Hu Tao
  • Patent number: 10561319
    Abstract: A system and method, for measuring phase delay and amplitude of a near infrared signal emanating from tissue of an animal subject in response a near infrared signal input to such tissue, operate by processing a signal from an optical detector and a corresponding signal from an optical detector emulation circuit. In some aspects, the processed signals are fed into a phase delay detection system that provides an output thereof a digital measure of the phase delay of the received optical signal.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: February 18, 2020
    Assignee: Tufts University
    Inventors: Valencia Koomson, Chirag Sthalekar
  • Patent number: 10544183
    Abstract: This disclosure relates to uridine nucleoside derivatives, compositions comprising therapeutically effective amounts of those nucleoside derivatives and methods of using those nucleoside derivatives or compositions in treating disorders that are responsive to ligands, such as agonists, of P2Y6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma and inflammatory conditions.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 28, 2020
    Assignee: TUFTS UNIVERSITY
    Inventors: Philip G. Haydon, Jinbo Lee
  • Patent number: 10513802
    Abstract: Disclosed herein are nanofibrillar materials and aerogel-like materials comprised of nanofibrils, and methods for making such materials.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: December 24, 2019
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Benedetto Marelli, Alexander Nicholas Mitropoulos
  • Publication number: 20190382443
    Abstract: Disclosed herein are cyclic peptides that induce cellular autophagy and have significant cell penetration activity. Methods for inducing autophagy and thereby treating various diseases and conditions associated with impaired autophagy are provided.
    Type: Application
    Filed: March 17, 2017
    Publication date: December 19, 2019
    Applicants: TRUSTEES OF TUFTS COLLEGE, BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: JOSHUA KRITZER, BETH LEVINE, LEILA PERARO
  • Patent number: 10485846
    Abstract: Provided herein are methods and compositions for the treatment of wounds in a mammalian subject. Particularly, novel bioactive polypeptides are provided that promote tissue repair and regeneration, including the activation of/stimulation of wound healing and wound closure, stimulate keratinocyte and endothelial cell motility and/or proliferation.
    Type: Grant
    Filed: December 11, 2015
    Date of Patent: November 26, 2019
    Assignee: Tufts University
    Inventors: Ira M. Herman, Tatiana Demidova-Rice
  • Patent number: 10464361
    Abstract: The present invention provides compositions and methods for printing a predetermined pattern on silk fibroin materials using water based “inks.” Such technique may be useful for micro- and nano-engineering applications.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: November 5, 2019
    Assignee: Tufts University
    Inventors: Fiorenzo G. Omenetto, David L. Kaplan, Miaomiao Yang, Hu Tao, Benedetto Marelli, Sunghwan Kim
  • Patent number: 10396173
    Abstract: The invention provides transient devices, including active and passive devices that electrically and/or physically transform upon application of at least one internal and/or external stimulus. Materials, modeling tools, manufacturing approaches, device designs and system level examples of transient electronics are provided.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: August 27, 2019
    Assignees: The Board of Trustees of the University of Illinois, Trustees of Tufts College
    Inventors: John A. Rogers, Fiorenzo G. Omenetto, Suk-Won Hwang, Hu Tao, Dae-Hyeong Kim, David Kaplan