Abstract: The present application provides methods of assaying for compounds that inhibit premature translation termination and nonsense mediated RNA decay in cells.
Abstract: High-throughput in vitro assays are provided for identifying modulators of transcription activity and RNA expression. New assays, related compositions, apparatus and integrated systems are provided.
Type:
Grant
Filed:
March 31, 1998
Date of Patent:
February 6, 2001
Assignee:
Tularik, Incorporated
Inventors:
Mohanram Sivaraja, Berta Strulovici, Osvaldo A. Flores