Abstract: The present application relates to a device and method of identifying and evaluating a tumor progression. The device or method can comprise: 1) a module or step capable of providing a clinical feature of a patient with the tumor; 2) a module or step capable of providing at least one biological indicator derived from the patient; 3) a module or step capable of determining a correlation between the at least one biological indicator of the individual patient and the clinical feature of the same patient; and 4) a module or step capable of evaluating a tumor progression or identifying an evaluation indicator of the correlation. The device or method of the present application are capable of providing guidance for study in potential molecular mechanisms of the tumor progression and providing the therapeutic strategy against the tumor progression.