Abstract: A sample reading apparatus and method. The apparatus includes a detection system for reading samples, a sample carrier support for holding a sample carrier in position for reading by the detection system, and a mask configured to expose selected portions of the sample carrier while covering other portions of the sample carrier such that the detection system reads the exposed portions of the sample carrier. At least one of the sample carrier and mask are movable to expose different portions of the sample carrier while covering other portions of the sample carrier.