Abstract: MiniVectors and compositions containing MiniVectors that target genes implicated in IPF selected from CDH11, STAT3, STAT6, FoxM1, MDM2, TGF?, SMAD, PDGFA, or TLR4 and/or increase intracellular levels of reduced glutathione, relaxin, and p53, are provided, along with uses in the treatment of idiopathic pulmonary fibrosis.
Type:
Application
Filed:
September 7, 2022
Publication date:
March 28, 2024
Applicants:
Twister Biotech, Inc, Baylor College of Medicine
Inventors:
E. Lynn ZECHIEDRICH, Lirio Milenka AREVALO-SOLIZ, Daniel James CATANESE, JR., Jonathan Marcus FOGG, Christopher E. COKER
Abstract: Compositions containing MiniVectors and gene therapy uses, including long term repeated gene therapy uses, to treat liver fibrosis or liver cancer.
Type:
Application
Filed:
October 20, 2022
Publication date:
June 22, 2023
Applicants:
BAYLOR COLLEGE OF MEDICINE, TWISTER BIOTECH, INC.
Inventors:
E. LYNN ZECHIEDRICH, LIRIO MILENKA AREVALO-SOLIZ, Daniel James CATANESE, JR., Jonathan Marcus FOGG, Christopher E. COKER, SANDEEP AGARWAL