Patents Assigned to Two Blades Foundation
  • Patent number: 11697820
    Abstract: Compositions and methods and for enhancing the resistance of plants to a plant disease caused by a Phytophthora species are provided. The compositions comprise nucleic acid molecules encoding resistance (R) gene products and variants thereof and plants, seeds, and plant cells comprising such nucleic acid molecules. The methods for enhancing the resistance of a plant to a plant disease caused by a Phytophthora species comprise introducing a nucleic acid molecule encoding an R gene product into a plant cell. Additionally provided are methods for using the plants in agriculture to limit plant disease.
    Type: Grant
    Filed: May 6, 2016
    Date of Patent: July 11, 2023
    Assignee: Two Blades Foundation
    Inventors: Kamil Witek, Jonathan D. G. Jones
  • Patent number: 11510377
    Abstract: Disclosed herein are compostions and methods for improving or enhancing pathogen resistance in legume plants. Compositions comprising polypeptides encoded by legume-derived nucleotide-binding site-leucine-rich repeat (NB-LRR) genes are useful in improving resistance in legumes to Asian soybean rust. Methods of using NB-LRR genes can be used to make a transgenic resistant legume plant.
    Type: Grant
    Filed: October 27, 2020
    Date of Patent: November 29, 2022
    Assignees: Two Blades Foundation, E. I. Du Pont De Nemours aand Company, Universidade Federal De Vicosa
    Inventors: Greg Rairdan, Karen Broglie, Gilda Rauscher, Hendrikus Pieter van Esse, Jonathan D. G. Jones, Cintia Goulart Kawashima, Sergio Herminio Brommonschenkel
  • Publication number: 20220251595
    Abstract: Compositions and methods for enhancing the disease resistance of plants are provided. The invention provides compositions comprising engineered, pattern recognition receptors which comprise one or more domains derived from the receptor-like protein AtRLP23, particularly a leucine-rich repeat domain, and one or more other domains including, for example, a kinase domain from a receptor-like kinase. The compositions further comprise nucleic acid molecules encoding the engineered proteins and plants, plant cells, and other host cells comprising such nucleic acid molecules and/or the engineered proteins. The invention additionally provides methods for making and using the engineered proteins and nucleic acid molecules encoding the engineered proteins.
    Type: Application
    Filed: June 26, 2020
    Publication date: August 11, 2022
    Applicant: Two Blades Foundation
    Inventors: Freddy France Guy Boutrot, Carolina Grandellis, Kamil Witek, Cyril B. Zipfel
  • Publication number: 20220135998
    Abstract: Compositions and methods and for enhancing the resistance of plants to plant diseases caused by potyviruses are provided. The compositions comprise nucleic acid molecules encoding resistance (R) gene products and variants thereof and plants, seeds, and plant cells comprising such nucleic acid molecules. The methods for enhancing the resistance of a plant to plant disease caused by a potyvirus comprise introducing a nucleic acid molecule encoding an R gene product into a plant cell. Additionally provided are methods for using the plants in agriculture to limit plant disease.
    Type: Application
    Filed: January 20, 2022
    Publication date: May 5, 2022
    Applicant: TWO BLADES FOUNDATION
    Inventors: Kamil Witek, Marta Grech-Baran, Jacek Hennig, Jonathan D.G. Jones, Waldemar Marczewski, Katarzyna Szajko
  • Patent number: 11041165
    Abstract: The present invention relates to the identification of the xcv-1 gene, which is responsible for a recessive resistance to Xanthomonas euvesicatoria, by genetic mapping-based cloning from Capsicum annuum. In addition, the invention relates to methods for generating plants resistant to an abiotic or biotic factor, in particular to Xanthomonas euvesicatoria, and the plants themselves, in particular tomato plants.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: June 22, 2021
    Assignee: Two Blades Foundation
    Inventors: György Botond Kiss, Zoltán Szabó, Carmen E Iliescu, Márta Balogh
  • Patent number: 11041166
    Abstract: Compositions and methods and for enhancing the resistance of plants to a plant disease caused by a Phytophthora species are provided. The compositions comprise nucleic acid molecules encoding resistance (R) gene products and variants thereof and plants, seeds, and plant cells comprising such nucleic acid molecules. The methods for enhancing the resistance of a plant to a plant disease caused by a Phytophthora species comprise introducing a nucleic acid molecule encoding an R gene product into a plant cell. Additionally provided are methods for using the plants in agriculture to limit plant disease.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: June 22, 2021
    Assignee: Two Blades Foundation
    Inventors: Kamil Witek, Hari S. Karki, Florian Gunter Jupe, Jonathan D. G. Jones
  • Publication number: 20210115465
    Abstract: Compositions and methods and for enhancing the resistance of plants to plant diseases caused by potyviruses are provided. The compositions comprise nucleic acid molecules encoding resistance (R) gene products and variants thereof and plants, seeds, and plant cells comprising such nucleic acid molecules. The methods for enhancing the resistance of a plant to plant disease caused by a potyvirus comprise introducing a nucleic acid molecule encoding an R gene product into a plant cell. Additionally provided are methods for using the plants in agriculture to limit plant disease.
    Type: Application
    Filed: July 27, 2018
    Publication date: April 22, 2021
    Applicant: TWO BLADES FOUNDATION
    Inventors: Kamil Witek, Marta Grech-Baran, Jacek Hennig, Jonathan D.G. Jones, Waldemar Marczewski, Katarzyna Szajko
  • Patent number: 10842097
    Abstract: Disclosed herein are compositions and methods for improving or enhancing pathogen resistance in legume plants. Compositions comprising polypeptides encoded by legume-derived nucleotide-binding site-leucine-rich repeat (NB-LRR) genes are useful in improving resistance in legumes to Asian soybean rust. Methods of using NB-LRR genes can be used to make a transgenic resistant legume plant.
    Type: Grant
    Filed: May 11, 2016
    Date of Patent: November 24, 2020
    Assignees: TWO BLADES FOUNDATION, E.I. DU PONT DE NEMOURS, UNIVERSIDADE FEDERAL DE VICOSA
    Inventors: Greg Rairdan, Karen Broglie, Gilda Rauscher, Hendrikus Pieter van Esse, Jonathan D. G. Jones, Cintia Goulart Kawashima, Sergio Herminio Brommonschenkel
  • Publication number: 20200362367
    Abstract: Compositions and methods and for enhancing the resistance of wheat plants to wheat stem rust caused by Puccinia graminis f. sp. tritici are provided. The compositions comprise nucleic acid molecules encoding resistance (R) gene products and variants thereof and plants, seeds, and plant cells comprising such nucleic acid molecules. The methods for enhancing the resistance of a wheat plant to wheat stem mst comprise introducing a nucleic acid molecule encoding an R gene product into a wheat plant cell. Additionally provided are methods for using the wheat plants in agriculture to limit wheat stem rust.
    Type: Application
    Filed: January 14, 2019
    Publication date: November 19, 2020
    Applicant: Two Blades Foundation
    Inventors: Burkhard Steuernagel, Sanu Arora, Brande Wulff
  • Publication number: 20180142254
    Abstract: Compositions and methods and for enhancing the resistance of plants to a plant disease caused by a Phytophthora species are provided. The compositions comprise nucleic acid molecules encoding resistance (R) gene products and variants thereof and plants, seeds, and plant cells comprising such nucleic acid molecules. The methods for enhancing the resistance of a plant to a plant disease caused by a Phytophthora species comprise introducing a nucleic acid molecule encoding an R gene product into a plant cell. Additionally provided are methods for using the plants in agriculture to limit plant disease.
    Type: Application
    Filed: May 6, 2016
    Publication date: May 24, 2018
    Applicant: TWO BLADES FOUNDATION
    Inventors: Kamil Witek, Jonathan D.G. Jones
  • Patent number: 9816103
    Abstract: Methods are provided for enhancing the resistance of plants to bacterial pathogens. The methods involve transforming a plant with a polynucleotide molecule comprising a plant promoter operably linked to a nucleotide sequence that encodes a plant receptor that binds specifically with bacterial elongation factor-Tu. Further provided are expression cassettes, transformed plants, seeds, and plant cells that are produced by such methods.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: November 14, 2017
    Assignee: Two Blades Foundation
    Inventors: Cyril B. Zipfel, Jonathan D. G. Jones
  • Patent number: 9222103
    Abstract: Methods are provided for enhancing the resistance of plants to bacterial pathogens. The methods involve transforming a plant with a polynucleotide molecule comprising a plant promoter operably linked to a nucleotide sequence that encodes a plant receptor that binds specifically with bacterial elongation factor-Tu. Further provided are expression cassettes, transformed plants, seeds, and plant cells that are produced by such methods.
    Type: Grant
    Filed: November 3, 2009
    Date of Patent: December 29, 2015
    Assignee: Two Blades Foundation
    Inventors: Cyril B. Zipfel, Jonathan D. G. Jones
  • Patent number: 9133467
    Abstract: Methods for producing pathogen-inducible promoters for the expression of genes in plants are provided. The pathogen-inducible promoters are inducible by one, two, three, or more plant pathogens. Methods for producing R genes that are inducible in a plant by more than one plant pathogen are further provided. Additionally, provided are R genes and other nucleic acid molecules comprising the pathogen-inducible promoters and that are made by such methods as well as plants, plant parts, plant cells, seeds, and non-human host cells comprising the R genes and other nucleic acid molecules.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: September 15, 2015
    Assignee: Two Blades Foundation
    Inventors: Thomas Lahaye, Patrick Römer, Sebastian Schornack, Jens Boch, Ulla Bonas
  • Publication number: 20140137292
    Abstract: Methods and compositions for making citrus plants with enhanced resistance to Asiatic citrus canker (ACC) and other forms of citrus canker caused by Xanthomonas are provided. The methods involve transforming citrus plant cells with polynucleotide constructs comprising a promoter operably linked to nucleotide sequence that encodes a protein that is capable of triggering cell death in a citrus plant. The promoters of the invention are inducible by one or more Xanthomonas strains that cause citrus canker. Isolated nucleic acid molecules and expression cassettes comprising such polynucleotide constructs and promoters are further provided. Citrus plants with enhanced resistance to citrus canker are also provided.
    Type: Application
    Filed: January 12, 2012
    Publication date: May 15, 2014
    Applicants: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION INC., TWO BLADES FOUNDATION
    Inventors: Jeffrey B. Jones, Thomas Lahaye, Brian J. Staskawicz
  • Publication number: 20130219555
    Abstract: Methods for producing pathogen-inducible promoters for the expression of genes in plants are provided. The pathogen-inducible promoters are inducible by one, two, three, or more plant pathogens. Methods for producing R genes that are inducible in a plant by more than one plant pathogen are further provided.
    Type: Application
    Filed: November 10, 2009
    Publication date: August 22, 2013
    Applicant: Two Blades Foundation
    Inventors: Thomas Lahaye, Patrick Römer, Sebastian Schornack, Jens Boch, Ulla Bonas
  • Publication number: 20130097734
    Abstract: Nucleic acid molecules that confer to a plant resistance to the plant pathogenic Phytophthora species are provided. These nucleic acid molecules can be introduced into plants that are otherwise susceptible to infection by certain strains of Phytophthora infestans or other Phytophthora species in order to enhance the resistance of the plant to this plant pathogen. Also provided are the resistance proteins encoded by these nucleic acid molecules. Methods of making nucleic acid molecules that confer upon a plant resistance to a plant pathogen, the nucleic acid molecules made by these methods, the resistance proteins encoded thereby, and methods of using these nucleic acid molecules to increase the resistance of plants to pathogens are further provided.
    Type: Application
    Filed: July 12, 2012
    Publication date: April 18, 2013
    Applicant: TWO BLADES FOUNDATION
    Inventors: Sophien Kamoun, Maria Eugenia Segretin, Sebastian Schornack
  • Patent number: 8198510
    Abstract: Isolated nucleic acid molecules that confer resistance to the plant pathogen Xanthomonas campestris are provided. These molecules may be introduced into plants that are otherwise susceptible to infection by this bacterium in order to enhance the resistance of the plant to this plant pathogen. Additionally provided are isolated polypeptides and isolated nucleic acid molecules comprising plant promoters. Methods of using the nucleic acid molecules to increase the resistance of plants to pathogens and to express genes of interest in plants are provided.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: June 12, 2012
    Assignee: Two Blades Foundation
    Inventors: Thomas Lahaye, Ulla Bonas, Patrick Römer
  • Publication number: 20100132069
    Abstract: Methods for producing pathogen-inducible promoters for the expression of genes in plants are provided. The pathogen-inducible promoters are inducible by one, two, three, or more plant pathogens. Methods for producing R genes that are inducible in a plant by more than one plant pathogen are further provided.
    Type: Application
    Filed: November 10, 2009
    Publication date: May 27, 2010
    Applicant: Two Blades Foundation
    Inventors: Thomas Lahaye, Patrick Rõmer, Sebastian Schornack, Jens Boch, Ulla Bonas
  • Publication number: 20100122376
    Abstract: Methods are provided for enhancing the resistance of plants to bacterial pathogens. The methods involve transforming a plant with a polynucleotide molecule comprising a plant promoter operably linked to a nucleotide sequence that encodes a plant receptor that binds specifically with bacterial elongation factor-Tu. Further provided are expression cassettes, transformed plants, seeds, and plant cells that are produced by such methods.
    Type: Application
    Filed: November 3, 2009
    Publication date: May 13, 2010
    Applicant: Two Blades Foundation
    Inventors: Cyril B. Zipfel, Jonathan D. G. Jones
  • Publication number: 20090133158
    Abstract: Isolated nucleic acid molecules that confer resistance to the plant pathogen Xanthomonas campestris are provided. These molecules may be introduced into plants that are otherwise susceptible to infection by this bacterium in order to enhance the resistance of the plant to this plant pathogen. Additionally provided are isolated polypeptides and isolated nucleic acid molecules comprising plant promoters. Methods of using the nucleic acid molecules to increase the resistance of plants to pathogens and to express genes of interest in plants are provided.
    Type: Application
    Filed: September 26, 2008
    Publication date: May 21, 2009
    Applicant: Two Blades Foundation
    Inventors: Thomas Lahaye, Ulla Bonas