Patents Assigned to TZU CHI UNIVERSITY
  • Patent number: 11826340
    Abstract: The present invention provides use of a compound represented by formula (1), and the use is manufacturing a medicine for treating or preventing ischemic optic neuropathy, wherein the formula (1) is as below:
    Type: Grant
    Filed: June 3, 2022
    Date of Patent: November 28, 2023
    Assignee: TZU CHI UNIVERSITY
    Inventors: Yu-Yau Chou, Jia-Ying Chien, Jhih-Wei Ciou, Shun-Ping Huang
  • Patent number: 11730667
    Abstract: A wearable stimulation device includes a wearable member, a stimulation unit, and a driver. The stimulation unit is secured to the wearable member. The stimulation unit includes an immovable end, a stimulation end, and a power element. The power element is connected between the immovable end and the stimulation end for driving the stimulation end to reciprocate relative to the immovable end. The driver is in signal connection with the power element. The driver is configured to output a vibration signal to the power element for the stimulation end to have a stroke of between 8.8 mm and 10.8 mm, a thrust of between 5.6 N and 7.6 N and a reciprocating frequency of between 180 Hz and 220 Hz, thereby stimulating the deep muscles of the abdomen or waist of a human body without affecting the superficial muscles.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: August 22, 2023
    Assignee: Tzu Chi University
    Inventors: Chich-Haung Yang, Ya-Hui Chang, Yu-Ming Chang, Cheng-Chun Cheng
  • Publication number: 20210317414
    Abstract: The present disclosure provides a soluble P-selectin (sP-sel) interfering the interaction between stem cells and niches to mobilize stem cells from bone marrow. The mobilization of stem cells with sP-sel can treat a subject in need of preservation, repair, or regeneration of a tissue, or revascularization.
    Type: Application
    Filed: April 14, 2020
    Publication date: October 14, 2021
    Applicant: TZU CHI UNIVERSITY
    Inventors: Hsin-Hou CHANG, Der-Shan SUN
  • Patent number: 11007176
    Abstract: The present invention relates to a novel use of actin depolymerizing agents, particularly cytochalasins or derivatives thereof for inhibiting or reversing actin polymerization. Therefore, the present invention provides a method for preventing or treating anxiety disorders and/or alleviating the symptoms thereof, comprising administering to a subject in need thereof a therapeutically effective amount of an actin depolymerizing agent or a derivative thereof.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: May 18, 2021
    Assignee: TZU CHI UNIVERSITY
    Inventors: Ingrid Yichun Liu, Hsien-Ting Huang, Chia-Sheng Pai
  • Publication number: 20200261412
    Abstract: The present invention relates to a novel use of actin depolymerizing agents, particularly cytochalasins or derivatives thereof for inhibiting or reversing actin polymerization. Therefore, the present invention provides a method for preventing or treating anxiety disorders and/or alleviating the symptoms thereof, comprising administering to a subject in need thereof a therapeutically effective amount of an actin depolymerizing agent or a derivative thereof.
    Type: Application
    Filed: February 19, 2019
    Publication date: August 20, 2020
    Applicant: TZU CHI UNIVERSITY
    Inventors: Ingrid Yichun LIU, Hsien-Ting Huang, Chia-Sheng Pai
  • Patent number: 10584154
    Abstract: The invention creates engineered surface protein expression on vesicles for specific targeting and delivery of agents to autophagic and apoptotic cells. Moreover, the vesicles of the invention can achieve a synergistic effect on the targeting and drug delivery to autophagic and apoptotic cells and autophagic and apoptotic cells-containing tissues.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: March 10, 2020
    Assignee: TZU CHI UNIVERSITY
    Inventors: Hsin-Hou Chang, Der-Shan Sun
  • Publication number: 20190388548
    Abstract: The present invention relates to a method for providing ocular neuroprotection or for preventing, treating or alleviating the effects of, an ocular disease associated with retinal ganglion cell death in a subject in need thereof, comprising administering to said subject an effective amount of a recombinant P-selectin immunoglobin G (P-sel-IgG) chimeric fusion protein, or a composition comprising the protein and a pharmaceutically acceptable adjuvant, vehicle, or carrier.
    Type: Application
    Filed: June 26, 2018
    Publication date: December 26, 2019
    Applicant: TZU CHI UNIVERSITY
    Inventors: Shun-Ping Huang, Rong-Kung Tsai
  • Patent number: 10500188
    Abstract: The present invention discloses use of a polyenylpyrrole derivative in preparation of an anti-oral cancer drugs. The polyenylpyrrole derivative synthesized by polyvinylpyrrole, auxarconjugatin A and 12E-isorumbrin inhibits the cell proliferation, migration, tumor sphere formation abilities and xenograft tumorigenicity of oral cancer cells.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: December 10, 2019
    Assignee: Tzu Chi University
    Inventors: Jeng-Woei Lee, Chia-Chen Lau, Kuo-Feng Hua, Yulin Lam
  • Publication number: 20190160037
    Abstract: This invention provides a method of treating, reducing, preventing deterioration or improving visual function after optic neuropathy in a subject in need thereof, comprising administering to the subject an effective amount of oroxylin A.
    Type: Application
    Filed: November 28, 2017
    Publication date: May 30, 2019
    Applicant: TZU CHI UNIVERSITY
    Inventor: Shun-Ping Huang
  • Patent number: 10123694
    Abstract: An optical measurement device including a light emitting element, a light pattern generating element and a light source transmission element is provided. The light pattern generating element includes a disk body, at least one round hole penetrating the disk body, at least one round disk embedded in the round hole, and at least two first magnetic elements disposed on the round disk. One end of the light source transmission element has two second magnetic elements. Through the magnetic connection of the first magnetic elements and the second magnetic elements, a chink on the round disk can rotate with the light source transmission element when the light source transmission element rotates. An optical measurement system including the optical measurement device is also provided.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: November 13, 2018
    Assignee: Tzu Chi University
    Inventor: Tsu-Wang Shen
  • Patent number: 9962487
    Abstract: An automatic sensing and warning device for placing an intravenous drip includes a transmitter unit, a blocking unit, a receiver unit, and a fixing device. The transmitter unit is attachable to an injection site on a patient's hand and is operable to transmit an identification signal. The receiver unit is arranged on the blocking unit and includes a drive circuit and a warning device. The fixing device supports the blocking unit and the receiver unit on the intravenous drip pole. The RF receiver is set at a predetermined vertical distance from a drip chamber and areas above and below the RF receiver are respectively defined as dangerous and safe areas. When the injection site is spaced from the drip chamber by a distance shorter than the predetermined distance, the RF receiver receives the identification signal from the RF transmitter and the drive circuit activates the warning device to issue warnings.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: May 8, 2018
    Assignees: CATHAY GENERAL HOSPITAL, TZU-CHI UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Ming-Chuan Kuo, Zu-Chun Lin, Chia-Hui Chu, Ping-I Li, Chia-Liang Lu
  • Publication number: 20170304219
    Abstract: The present invention relates to a method of treating or preventing the visual function loss in optic nerve in a subject after crush injury by using 4-(Phenylsulfanyl)butane-2-one (4-PSB-2). The present invention has the ability of enhancing the protection effect of RGCs, preserving the visual function in optic nerve after crush injury, recovering the visual function loss, attenuating apoptosis in optic nerve after injury, and inhibiting the inflammatory responses in optic nerves after ON injury.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 26, 2017
    Applicants: NATIONAL SUN YAT-SEN UNIVERSITY, TZU-CHI UNIVERSITY
    Inventors: SHUN-PING HUANG, JYH-HORNG SHEU, ZHI-HONG WEN, RONG-KUNG TSAI
  • Patent number: 9258300
    Abstract: The present invention discloses at least two electrodes disposed at the body of the ECG measuring device of the present invention. When a user normally uses the ECG measuring device, the two electrodes are just adhered to the hands and the face of the user. The ECG measuring method of the present invention is to measure a first ECG signal from the left hand to the left side of face of the user and a second ECG signal from the right hand to the right side of face of the user. Then a plurality of ECG features are obtained from the first ECG signal, the second ECG signal and the result, as related coefficients, of the interactive computing, as a method of plus and subtract, of the first ECG signal and the second ECG signal. Hence, a biometric authorization process is engaged according to the plurality of ECG features.
    Type: Grant
    Filed: October 29, 2013
    Date of Patent: February 9, 2016
    Assignee: TZU CHI UNIVERSITY
    Inventor: Tsu-Wang Shen
  • Publication number: 20140284348
    Abstract: A medicine packet dispensing device with an automatic reminder function comprises a box having a medicine discharge hole; a control device arranged in the box; and a medicine discharge module arranged in the box. The control device includes a processor used to set at least one medication time; at least one reminder unit controlled by the control device to emit an alert according to the medication time; and a plurality of medicine discharge operating interfaces used to input an instruction to the processor to enable the processor to generate a medicine discharge signal to the medicine discharge module. The medicine discharge module has medicine packet accommodation spaces for accommodating medicine packets and sends one medicine packet to the medicine discharge hole according to the medicine discharge signal. The present invention reminds the user to take medicine at designated times and allows the user to change the medication times.
    Type: Application
    Filed: March 4, 2014
    Publication date: September 25, 2014
    Applicant: TZU CHI UNIVERSITY
    Inventor: JEN-LIANG CHENG
  • Patent number: 8812090
    Abstract: A calibration method of electrocardiogram signals and the application program for the same. The method comprises steps of receiving an uncalibrated/unidentified electrocardiogram signal of a user, calculating the ratio of the distance length of an uncalibrated/unidentified electrocardiogram signal and the distance length of an electrocardiogram template, then generating a trigonometric value which corresponds with a trigonometric projection degree according to the ratio. Next step is to set a characteristic point of the uncalibrated electrocardiogram signal as an axis anchor point of the trigonometric projection for attaining a displacement. Lastly, perform the calibration on the unidentified electrocardiogram signal according to the generated trigonometric value which corresponds with trigonometric projection degree and the attained displacement. Then perform identification comparison of the unidentified electrocardiogram signal and the saved electrocardiogram template for further authorization.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: August 19, 2014
    Assignee: Tzu Chi University
    Inventors: Tsu-Wang Shen, Shan-Chun Chang
  • Publication number: 20140120876
    Abstract: The present invention discloses at least two electrodes disposed at the body of the ECG measuring device of the present invention. When a user normally uses the ECG measuring device, the two electrodes are just adhered to the hands and the face of the user. The ECG measuring method of the present invention is to measure a first ECG signal from the left hand to the left side of face of the user and a second ECG signal from the right hand to the right side of face of the user. Then a plurality of ECG features are obtained from the first ECG signal, the second ECG signal and the result, as related coefficients, of the interactive computing, as a method of plus and subtract, of the first ECG signal and the second ECG signal. Hence, a biometric authorization process is engaged according to the plurality of ECG features.
    Type: Application
    Filed: October 29, 2013
    Publication date: May 1, 2014
    Applicant: TZU CHI UNIVERSITY
    Inventor: Tsu-Wang SHEN
  • Publication number: 20130303788
    Abstract: A method of producing honokiol and analogues thereof, and novel intermediates prepared by virtue thereof are disclosed herein. A pharmaceutical composition for treating Parkinson's disease, which contains honokiol and/or the analogues thereof, is also disclosed herein.
    Type: Application
    Filed: September 14, 2012
    Publication date: November 14, 2013
    Applicant: Tzu Chi University
    Inventors: Ming-Huan Chan, Chinpiao Chen, Hwei-Hsien Chen
  • Publication number: 20100167876
    Abstract: An RFID-based exercise behavior management system is disclosed. The system comprises an RFID tag, a front-end subsystem and a back-end subsystem. The RFID tag contains a unique identification for a participant and is carried by or implanted in the participant whose exercise behavior can be recorded automatically when he is engaging exercise in the field where the front-end subsystem is installed. The backend subsystem enables the recorded exercise behavior to be accessed ubiquitously and to be delivered to related personnel. Thus this invention helps any health promoting agent in realizing and developing trackable exercise programs.
    Type: Application
    Filed: December 29, 2008
    Publication date: July 1, 2010
    Applicant: TZU CHI UNIVERSITY
    Inventor: Jen-Liang Cheng