Patents Assigned to TZU CHI UNIVERSITY
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Patent number: 12188049Abstract: The present disclosure provides a soluble P-selectin (sP-sel) interfering the interaction between stem cells and niches to mobilize stem cells from bone marrow. The mobilization of stem cells with sP-sel can treat a subject in need of preservation, repair, or regeneration of a tissue, or revascularization.Type: GrantFiled: April 14, 2020Date of Patent: January 7, 2025Assignee: TZU CHI UNIVERSITYInventors: Hsin-Hou Chang, Der-Shan Sun
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Patent number: 12129279Abstract: The present invention relates to novel antimicrobial peptides and compositions comprising the same. The present invention also provides a method for for treating microbial infections, including bacterial infections and fungal infections.Type: GrantFiled: December 2, 2022Date of Patent: October 29, 2024Assignee: TZU CHI UNIVERSITYInventors: Je-Wen Liou, Yu-Ren Chen, Chin-Hao Yang
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Publication number: 20240182527Abstract: The present invention relates to novel antimicrobial peptides and compositions comprising the same. The present invention also provides a method for for treating microbial infections, including bacterial infections and fungal infections.Type: ApplicationFiled: December 2, 2022Publication date: June 6, 2024Applicant: TZU CHI UNIVERSITYInventors: Je-Wen LIOU, Yu-Ren CHEN, Chin-Hao YANG
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Patent number: 11826340Abstract: The present invention provides use of a compound represented by formula (1), and the use is manufacturing a medicine for treating or preventing ischemic optic neuropathy, wherein the formula (1) is as below:Type: GrantFiled: June 3, 2022Date of Patent: November 28, 2023Assignee: TZU CHI UNIVERSITYInventors: Yu-Yau Chou, Jia-Ying Chien, Jhih-Wei Ciou, Shun-Ping Huang
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Publication number: 20210317414Abstract: The present disclosure provides a soluble P-selectin (sP-sel) interfering the interaction between stem cells and niches to mobilize stem cells from bone marrow. The mobilization of stem cells with sP-sel can treat a subject in need of preservation, repair, or regeneration of a tissue, or revascularization.Type: ApplicationFiled: April 14, 2020Publication date: October 14, 2021Applicant: TZU CHI UNIVERSITYInventors: Hsin-Hou CHANG, Der-Shan SUN
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Patent number: 11007176Abstract: The present invention relates to a novel use of actin depolymerizing agents, particularly cytochalasins or derivatives thereof for inhibiting or reversing actin polymerization. Therefore, the present invention provides a method for preventing or treating anxiety disorders and/or alleviating the symptoms thereof, comprising administering to a subject in need thereof a therapeutically effective amount of an actin depolymerizing agent or a derivative thereof.Type: GrantFiled: February 19, 2019Date of Patent: May 18, 2021Assignee: TZU CHI UNIVERSITYInventors: Ingrid Yichun Liu, Hsien-Ting Huang, Chia-Sheng Pai
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Publication number: 20200261412Abstract: The present invention relates to a novel use of actin depolymerizing agents, particularly cytochalasins or derivatives thereof for inhibiting or reversing actin polymerization. Therefore, the present invention provides a method for preventing or treating anxiety disorders and/or alleviating the symptoms thereof, comprising administering to a subject in need thereof a therapeutically effective amount of an actin depolymerizing agent or a derivative thereof.Type: ApplicationFiled: February 19, 2019Publication date: August 20, 2020Applicant: TZU CHI UNIVERSITYInventors: Ingrid Yichun LIU, Hsien-Ting Huang, Chia-Sheng Pai
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Patent number: 10584154Abstract: The invention creates engineered surface protein expression on vesicles for specific targeting and delivery of agents to autophagic and apoptotic cells. Moreover, the vesicles of the invention can achieve a synergistic effect on the targeting and drug delivery to autophagic and apoptotic cells and autophagic and apoptotic cells-containing tissues.Type: GrantFiled: December 27, 2017Date of Patent: March 10, 2020Assignee: TZU CHI UNIVERSITYInventors: Hsin-Hou Chang, Der-Shan Sun
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Publication number: 20190388548Abstract: The present invention relates to a method for providing ocular neuroprotection or for preventing, treating or alleviating the effects of, an ocular disease associated with retinal ganglion cell death in a subject in need thereof, comprising administering to said subject an effective amount of a recombinant P-selectin immunoglobin G (P-sel-IgG) chimeric fusion protein, or a composition comprising the protein and a pharmaceutically acceptable adjuvant, vehicle, or carrier.Type: ApplicationFiled: June 26, 2018Publication date: December 26, 2019Applicant: TZU CHI UNIVERSITYInventors: Shun-Ping Huang, Rong-Kung Tsai
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Publication number: 20190160037Abstract: This invention provides a method of treating, reducing, preventing deterioration or improving visual function after optic neuropathy in a subject in need thereof, comprising administering to the subject an effective amount of oroxylin A.Type: ApplicationFiled: November 28, 2017Publication date: May 30, 2019Applicant: TZU CHI UNIVERSITYInventor: Shun-Ping Huang
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Patent number: 9962487Abstract: An automatic sensing and warning device for placing an intravenous drip includes a transmitter unit, a blocking unit, a receiver unit, and a fixing device. The transmitter unit is attachable to an injection site on a patient's hand and is operable to transmit an identification signal. The receiver unit is arranged on the blocking unit and includes a drive circuit and a warning device. The fixing device supports the blocking unit and the receiver unit on the intravenous drip pole. The RF receiver is set at a predetermined vertical distance from a drip chamber and areas above and below the RF receiver are respectively defined as dangerous and safe areas. When the injection site is spaced from the drip chamber by a distance shorter than the predetermined distance, the RF receiver receives the identification signal from the RF transmitter and the drive circuit activates the warning device to issue warnings.Type: GrantFiled: August 11, 2017Date of Patent: May 8, 2018Assignees: CATHAY GENERAL HOSPITAL, TZU-CHI UNIVERSITY OF SCIENCE AND TECHNOLOGYInventors: Ming-Chuan Kuo, Zu-Chun Lin, Chia-Hui Chu, Ping-I Li, Chia-Liang Lu
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Publication number: 20170304219Abstract: The present invention relates to a method of treating or preventing the visual function loss in optic nerve in a subject after crush injury by using 4-(Phenylsulfanyl)butane-2-one (4-PSB-2). The present invention has the ability of enhancing the protection effect of RGCs, preserving the visual function in optic nerve after crush injury, recovering the visual function loss, attenuating apoptosis in optic nerve after injury, and inhibiting the inflammatory responses in optic nerves after ON injury.Type: ApplicationFiled: October 21, 2016Publication date: October 26, 2017Applicants: NATIONAL SUN YAT-SEN UNIVERSITY, TZU-CHI UNIVERSITYInventors: SHUN-PING HUANG, JYH-HORNG SHEU, ZHI-HONG WEN, RONG-KUNG TSAI
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Patent number: 9258300Abstract: The present invention discloses at least two electrodes disposed at the body of the ECG measuring device of the present invention. When a user normally uses the ECG measuring device, the two electrodes are just adhered to the hands and the face of the user. The ECG measuring method of the present invention is to measure a first ECG signal from the left hand to the left side of face of the user and a second ECG signal from the right hand to the right side of face of the user. Then a plurality of ECG features are obtained from the first ECG signal, the second ECG signal and the result, as related coefficients, of the interactive computing, as a method of plus and subtract, of the first ECG signal and the second ECG signal. Hence, a biometric authorization process is engaged according to the plurality of ECG features.Type: GrantFiled: October 29, 2013Date of Patent: February 9, 2016Assignee: TZU CHI UNIVERSITYInventor: Tsu-Wang Shen
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Publication number: 20140284348Abstract: A medicine packet dispensing device with an automatic reminder function comprises a box having a medicine discharge hole; a control device arranged in the box; and a medicine discharge module arranged in the box. The control device includes a processor used to set at least one medication time; at least one reminder unit controlled by the control device to emit an alert according to the medication time; and a plurality of medicine discharge operating interfaces used to input an instruction to the processor to enable the processor to generate a medicine discharge signal to the medicine discharge module. The medicine discharge module has medicine packet accommodation spaces for accommodating medicine packets and sends one medicine packet to the medicine discharge hole according to the medicine discharge signal. The present invention reminds the user to take medicine at designated times and allows the user to change the medication times.Type: ApplicationFiled: March 4, 2014Publication date: September 25, 2014Applicant: TZU CHI UNIVERSITYInventor: JEN-LIANG CHENG
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Publication number: 20140120876Abstract: The present invention discloses at least two electrodes disposed at the body of the ECG measuring device of the present invention. When a user normally uses the ECG measuring device, the two electrodes are just adhered to the hands and the face of the user. The ECG measuring method of the present invention is to measure a first ECG signal from the left hand to the left side of face of the user and a second ECG signal from the right hand to the right side of face of the user. Then a plurality of ECG features are obtained from the first ECG signal, the second ECG signal and the result, as related coefficients, of the interactive computing, as a method of plus and subtract, of the first ECG signal and the second ECG signal. Hence, a biometric authorization process is engaged according to the plurality of ECG features.Type: ApplicationFiled: October 29, 2013Publication date: May 1, 2014Applicant: TZU CHI UNIVERSITYInventor: Tsu-Wang SHEN
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Publication number: 20100167876Abstract: An RFID-based exercise behavior management system is disclosed. The system comprises an RFID tag, a front-end subsystem and a back-end subsystem. The RFID tag contains a unique identification for a participant and is carried by or implanted in the participant whose exercise behavior can be recorded automatically when he is engaging exercise in the field where the front-end subsystem is installed. The backend subsystem enables the recorded exercise behavior to be accessed ubiquitously and to be delivered to related personnel. Thus this invention helps any health promoting agent in realizing and developing trackable exercise programs.Type: ApplicationFiled: December 29, 2008Publication date: July 1, 2010Applicant: TZU CHI UNIVERSITYInventor: Jen-Liang Cheng