Patents Assigned to U, LLC
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Publication number: 20250213863Abstract: The patent application describes an adaptable neuromodulation device for transcranial electrical brain stimulation. The system can generate complex poly-modulated waveforms by combining multiple pulse parameters in a randomized manner across dimensions like amplitude, frequency, phase, timing, and polarity. It leverages both digital and analog modulation techniques for waveform versatility. The device features pathway optimization algorithms that tune stimulation using neural feedback data to target specific brain region shapes with greater precision. It also enables closed-loop operation for responsiveness to physiological changes. The application details the mathematical and computational foundations, spanning graph theory to generate digital twins. It highlights applications from cognitive enhancement to seizure control. Overall, the innovation promises versatility and precision in non-invasive neuromodulation through adaptable, optimized waveforms grounded in sophisticated modeling.Type: ApplicationFiled: December 26, 2024Publication date: July 3, 2025Applicant: U LLCInventors: M Abouelsoud, David J. Mishelevich
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Patent number: 11896833Abstract: An invention and method that generate dynamical shaped voltage-gradient geometries through a plurality of dual-modal electrode-contacts placed around the biological tissue in vivo. The geometry of the voltage gradient is optimized through a feedback mechanism from the plurality of dual-modal electrode-contacts that can record electric and magnetic field potentials in the biological tissue. A control controls the waveform signal between sets of electrode-contacts to generate dynamically shaped voltage gradients to modulate a specific set of properties in the biological tissue. A method of analysis for the recorded electric and magnetic field potentials is purposed to optimize the shape of the voltage-gradient geometry through modulation of the waveform signal that is sent through the dual-modal electrode-contacts.Type: GrantFiled: December 11, 2022Date of Patent: February 13, 2024Assignee: U LLCInventors: Mohammed Abouelsoud, David J. Mishelevich
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Publication number: 20230241403Abstract: An invention and method that generate dynamical shaped voltage-gradient geometries through a plurality of dual-modal electrode-contacts placed around the biological tissue in vivo. The geometry of the voltage gradient is optimized through a feedback mechanism from the plurality of dual-modal electrode-contacts that can record electric and magnetic field potentials in the biological tissue. A control controls the waveform signal between sets of electrode-contacts to generate dynamically shaped voltage gradients to modulate a specific set of properties in the biological tissue. A method of analysis for the recorded electric and magnetic field potentials is purposed to optimize the shape of the voltage-gradient geometry through modulation of the waveform signal that is sent through the dual-modal electrode-contacts.Type: ApplicationFiled: December 11, 2022Publication date: August 3, 2023Applicant: U LLCInventors: Mohammed Abouelsoud, David J. Mishelevich
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Patent number: 11654281Abstract: Neurostimulation devices and methods provide a plurality of electrodes placed around a patient head such that electrode have electrical paths through the brain to other electrodes. A controller controls current between sets of opposing electrodes through the patient brain to selectively stimulate a region of interest of the patient brain. Different sets of electrodes are used to provide electrical current pulse with different polarities such that a net potential is exposed to a region of interest in the brain that it above a neuron stimulation threshold while a net potential exposed to tissue outside the region of interest is below the threshold.Type: GrantFiled: June 1, 2021Date of Patent: May 23, 2023Assignee: U, LLCInventor: Mohammed Abouelsoud
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Patent number: 11071694Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.Type: GrantFiled: May 31, 2018Date of Patent: July 27, 2021Assignee: Rose U, LLCInventors: Michael Johnston, Robert James Houlden
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Patent number: 10052267Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.Type: GrantFiled: July 27, 2017Date of Patent: August 21, 2018Assignee: ROSE U, LLCInventors: Michael Johnston, Robert James Houlden
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Patent number: 9744105Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.Type: GrantFiled: November 19, 2013Date of Patent: August 29, 2017Assignee: ROSE U, LLCInventors: Michael Johnston, Robert James Houlden
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Patent number: 8974798Abstract: Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.Type: GrantFiled: June 16, 2011Date of Patent: March 10, 2015Assignee: Zoetis P&U LLCInventors: David E. Lowery, Troy E. Fuller, Michael J. Kennedy
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Patent number: 8968759Abstract: A method of administering an antibiotic to an animal in need thereof, including the step of injecting the antibiotic subcutaneously at the junction of a pinna with the cranium of the animal, is disclosed.Type: GrantFiled: October 27, 2010Date of Patent: March 3, 2015Assignee: Zoetis P&U LLCInventor: Scott A. Brown
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Patent number: 8486685Abstract: The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus.Type: GrantFiled: September 29, 2011Date of Patent: July 16, 2013Assignee: Zoetis P&U LLCInventors: Jay Gregory Calvert, Shelly Shields, David E Slade, Siao-Kun Welch
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Patent number: 8420646Abstract: The present invention is directed to tricyclic tetrahydroquinoline compounds of formula I, and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R5, R20 and X are as described herein and to pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.Type: GrantFiled: December 20, 2010Date of Patent: April 16, 2013Assignee: PAH P&U LLCInventors: Michael Robert Barbachyn, Paul Joseph Dobrowolski, Alexander Ross Hurd, Dennis Joseph McNamara, John Raymond Palmer, Arthur Glenn Romero, J. Craig Ruble, Debra Ann Sherry, Lisa Marie Thomasco, Peter Laurence Toogood
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Publication number: 20110004517Abstract: Embodiments of the invention provide systems and methods for providing an interactive media player with e-commerce functions. According to one embodiment, a method of providing an interactive media player can comprise generating and displaying with a commerce management server a media player including content area, the content area adapted to display a selected content. The media player can also include a content library of available content, and a favorites area of the media player based on a user of the media player. An indication of the selected content can be received and the selected content can be played in the content area of the media player. An interactive ad can be selected based on the selected content and displayed in a lower third banner of the content area during playout of the selected content.Type: ApplicationFiled: June 25, 2010Publication date: January 6, 2011Applicant: The Jungle U LLCInventors: Santos Soto, Marc Tenedora
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Publication number: 20110004533Abstract: Embodiments of the invention provide systems and methods for distribution and promotion of one or more products through a Viral Store Application (VSA). According to one embodiment, a method of providing a Viral Store Application (VSA) can comprise receiving a request at a commerce management server, the request to create a new VSA on a system remote from the commerce management server. Links between the new VSA and product information for each of one or more products stored on one or more servers remote from the commerce management server can be defined. The links between the new VSA and the product information can be stored as a definition for the new VSA. A link to the definition for the new VSA can be inserted into a web page on the system remote from the commerce management server.Type: ApplicationFiled: June 25, 2010Publication date: January 6, 2011Applicant: The Jungle U LLCInventors: Santos Soto, Marc Tenedora