Patents Assigned to U, LLC
  • Publication number: 20250213863
    Abstract: The patent application describes an adaptable neuromodulation device for transcranial electrical brain stimulation. The system can generate complex poly-modulated waveforms by combining multiple pulse parameters in a randomized manner across dimensions like amplitude, frequency, phase, timing, and polarity. It leverages both digital and analog modulation techniques for waveform versatility. The device features pathway optimization algorithms that tune stimulation using neural feedback data to target specific brain region shapes with greater precision. It also enables closed-loop operation for responsiveness to physiological changes. The application details the mathematical and computational foundations, spanning graph theory to generate digital twins. It highlights applications from cognitive enhancement to seizure control. Overall, the innovation promises versatility and precision in non-invasive neuromodulation through adaptable, optimized waveforms grounded in sophisticated modeling.
    Type: Application
    Filed: December 26, 2024
    Publication date: July 3, 2025
    Applicant: U LLC
    Inventors: M Abouelsoud, David J. Mishelevich
  • Patent number: 11896833
    Abstract: An invention and method that generate dynamical shaped voltage-gradient geometries through a plurality of dual-modal electrode-contacts placed around the biological tissue in vivo. The geometry of the voltage gradient is optimized through a feedback mechanism from the plurality of dual-modal electrode-contacts that can record electric and magnetic field potentials in the biological tissue. A control controls the waveform signal between sets of electrode-contacts to generate dynamically shaped voltage gradients to modulate a specific set of properties in the biological tissue. A method of analysis for the recorded electric and magnetic field potentials is purposed to optimize the shape of the voltage-gradient geometry through modulation of the waveform signal that is sent through the dual-modal electrode-contacts.
    Type: Grant
    Filed: December 11, 2022
    Date of Patent: February 13, 2024
    Assignee: U LLC
    Inventors: Mohammed Abouelsoud, David J. Mishelevich
  • Publication number: 20230241403
    Abstract: An invention and method that generate dynamical shaped voltage-gradient geometries through a plurality of dual-modal electrode-contacts placed around the biological tissue in vivo. The geometry of the voltage gradient is optimized through a feedback mechanism from the plurality of dual-modal electrode-contacts that can record electric and magnetic field potentials in the biological tissue. A control controls the waveform signal between sets of electrode-contacts to generate dynamically shaped voltage gradients to modulate a specific set of properties in the biological tissue. A method of analysis for the recorded electric and magnetic field potentials is purposed to optimize the shape of the voltage-gradient geometry through modulation of the waveform signal that is sent through the dual-modal electrode-contacts.
    Type: Application
    Filed: December 11, 2022
    Publication date: August 3, 2023
    Applicant: U LLC
    Inventors: Mohammed Abouelsoud, David J. Mishelevich
  • Patent number: 11654281
    Abstract: Neurostimulation devices and methods provide a plurality of electrodes placed around a patient head such that electrode have electrical paths through the brain to other electrodes. A controller controls current between sets of opposing electrodes through the patient brain to selectively stimulate a region of interest of the patient brain. Different sets of electrodes are used to provide electrical current pulse with different polarities such that a net potential is exposed to a region of interest in the brain that it above a neuron stimulation threshold while a net potential exposed to tissue outside the region of interest is below the threshold.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: May 23, 2023
    Assignee: U, LLC
    Inventor: Mohammed Abouelsoud
  • Patent number: 11071694
    Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: July 27, 2021
    Assignee: Rose U, LLC
    Inventors: Michael Johnston, Robert James Houlden
  • Patent number: 10052267
    Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: August 21, 2018
    Assignee: ROSE U, LLC
    Inventors: Michael Johnston, Robert James Houlden
  • Patent number: 9744105
    Abstract: Individually packaged topical formulations comprising about 0.25 to about 6% w/w of glycopyrrolate for the treatment of hyperhidrosis, wherein said wipe is contained within a pouch resistant to leakage. The formulations may further comprise ethanol, a buffering agent and water. In addition, the formulations may further comprise a polymer system comprising a hydrophobic polymer in combination with a hydrophilic polymer.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: August 29, 2017
    Assignee: ROSE U, LLC
    Inventors: Michael Johnston, Robert James Houlden
  • Patent number: 8974798
    Abstract: Gram negative bacterial virulence genes are identified, thereby allowing the identification of novel anti-bacterial agents that target these virulence genes and their products, and the provision of novel gram negative bacterial mutants useful in vaccines.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: March 10, 2015
    Assignee: Zoetis P&U LLC
    Inventors: David E. Lowery, Troy E. Fuller, Michael J. Kennedy
  • Patent number: 8968759
    Abstract: A method of administering an antibiotic to an animal in need thereof, including the step of injecting the antibiotic subcutaneously at the junction of a pinna with the cranium of the animal, is disclosed.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: March 3, 2015
    Assignee: Zoetis P&U LLC
    Inventor: Scott A. Brown
  • Patent number: 8486685
    Abstract: The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: July 16, 2013
    Assignee: Zoetis P&U LLC
    Inventors: Jay Gregory Calvert, Shelly Shields, David E Slade, Siao-Kun Welch
  • Patent number: 8420646
    Abstract: The present invention is directed to tricyclic tetrahydroquinoline compounds of formula I, and pharmaceutically acceptable salts thereof wherein the variables R1, R2, R3, R4, R5, R20 and X are as described herein and to pharmaceutical compositions thereof, that exhibit useful antibacterial activity against a wide range of human and veterinary pathogens.
    Type: Grant
    Filed: December 20, 2010
    Date of Patent: April 16, 2013
    Assignee: PAH P&U LLC
    Inventors: Michael Robert Barbachyn, Paul Joseph Dobrowolski, Alexander Ross Hurd, Dennis Joseph McNamara, John Raymond Palmer, Arthur Glenn Romero, J. Craig Ruble, Debra Ann Sherry, Lisa Marie Thomasco, Peter Laurence Toogood
  • Publication number: 20110004517
    Abstract: Embodiments of the invention provide systems and methods for providing an interactive media player with e-commerce functions. According to one embodiment, a method of providing an interactive media player can comprise generating and displaying with a commerce management server a media player including content area, the content area adapted to display a selected content. The media player can also include a content library of available content, and a favorites area of the media player based on a user of the media player. An indication of the selected content can be received and the selected content can be played in the content area of the media player. An interactive ad can be selected based on the selected content and displayed in a lower third banner of the content area during playout of the selected content.
    Type: Application
    Filed: June 25, 2010
    Publication date: January 6, 2011
    Applicant: The Jungle U LLC
    Inventors: Santos Soto, Marc Tenedora
  • Publication number: 20110004533
    Abstract: Embodiments of the invention provide systems and methods for distribution and promotion of one or more products through a Viral Store Application (VSA). According to one embodiment, a method of providing a Viral Store Application (VSA) can comprise receiving a request at a commerce management server, the request to create a new VSA on a system remote from the commerce management server. Links between the new VSA and product information for each of one or more products stored on one or more servers remote from the commerce management server can be defined. The links between the new VSA and the product information can be stored as a definition for the new VSA. A link to the definition for the new VSA can be inserted into a web page on the system remote from the commerce management server.
    Type: Application
    Filed: June 25, 2010
    Publication date: January 6, 2011
    Applicant: The Jungle U LLC
    Inventors: Santos Soto, Marc Tenedora