Abstract: A method for preventing or treating opioid induced changes in gastrointestinal motility. The method comprises administering methylnaltrexone or another quaternary derivative of noroxymorphone to a patient prior to the administration of an opioid or after the onset of side effects induced by the administration of an opioid, wherein the methylnaltrexone or quaternary derivative is administered orally in an enterically coated form.
Type:
Grant
Filed:
May 21, 2001
Date of Patent:
August 19, 2003
Assignees:
The University of Chicago, U.R. Labs
Inventors:
Joseph F. Foss, Michael F. Roizen, Jonathan Moss, Chun-Su Yuan, William Drell