Abstract: The present invention relates to methods of stimulating he growth of hematopoietic progenitor cells. In particular, it relates to the use of thiols and related compounds in stimulating the growth of hematopoietic progenitor cells in vitro and in vivo. Furthermore, the present invention relates to methods of using these compounds for the treatment of marrow failure states and immunodeficient conditions, including but not limited to myelodysplastic syndromes and acquired immunodeficiency syndrome.
Type:
Grant
Filed:
March 24, 1998
Date of Patent:
May 25, 1999
Assignees:
Arizona Board of Regents on behalf of The University of Arizona, U.S. Bioscience
Abstract: S-.omega.(.omega.-aminoalkylamino)alkyl dihydrogen phosphorothioates or pharmaceutically acceptable derivatives thereof are useful in protecting a patient undergoing AZT treatment for AIDS and AIDS-related complex from the harmful side effects or reactions and toxicity of the AZT.
Abstract: The present invention is directed toward methods for the reduction of the severity of symptoms resulting from tumors, such as pain induced by the pressure exerted on a nerve by the tumor mass. Additionally, methods for the reduction of tumor size are also contemplated.
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